Therapeutic Strategies in Dermatology

Histiocytosis X/Langerhans Cell Histiocytoses

A malignant neoplasm made up of abnormal germinative cells analogous to those that compose the folliculosebaceous-apocrine germ in an embryo and that usually manifests clinically as a papule or nodule which may become ulcerated. On the basis of clin…

Therapeutic Strategies in Dermatology

Vascular Birthmarks: Key Points

…orized as vascular tumors or vascular malformations. The term hemangioma has previously been used to describe many common, typically benign vascular birthmarks that present in infancy with a wide spectrum of clinical presentations. Recent changes in…

A Clinical Atlas of 101 Common Skin Diseases

Lymphomas (Other Than Mycosis Fungoides and Lymphomatoid Papulosis)

…in clusters on any anatomic site. When “primary,” B-cell lymphomas of the skin seem to be wholly cutaneous with no evidence of extracutaneous manifestations after complete staging has been performed. The major categories of primary cutaneou…

Therapeutic Strategies in Dermatology

Histiocytosis X/Langerhans Cell Histiocytoses: Overview

Overview Langerhans cell histiocytoses (Class I histiocytosis) are a group of disorders most common in childhood due to the accumulation or proliferation of a clonal population of cells bearing the phenotype of a Langerhans cell that has been arrest…

Therapeutic Strategies in Dermatology

Cutaneous T-Cell Lymphoma/ Mycosis Fungoides: Overview

Overview Therapy of cutaneous T-cell lymphoma often requires specialized knowledge, and for this reason it is often appropriate to refer such patients to a medical center with specialized knowledge in the management of CTCL. Since early aggressive t…

Therapeutic Strategies in Dermatology

Kaposi’s Sarcoma: Overview

…Overview Kaposi’s sarcoma (KS) results from endothelial cell proliferation caused by infection with human herpesvirus 8 and occurs in four settings: classic KS, African (endemic) KS, immunosuppressive-associated KS, and AIDS-associated KS. The…

Therapeutic Strategies in Dermatology

Vascular Birthmarks: Initial Evaluation

Initial Evaluation Hemangioma of infancy Port-wine stain Differential diagnosis Cherry hemangioma Tufted hemangioma Spider angioma Lymphangioma circumscriptum…

Therapeutic Strategies in Dermatology

Vascular Birthmarks: Treatment

Treatment Treatment of hemangioma of infancy HOI present shortly after birth, and undergo periods of rapid growth during infancy and spontaneous involution during infancy or childhood. Rapid growth may cause severe disfigurement, vision impairment,…

Differential Diagnosis in Dermatopathology

"Pseudolymphoma," B-cell type vs. Malignant lymphoma, B-cell type

…in clusters on any anatomic site. When “primary,” B-cell lymphomas of the skin seem to be wholly cutaneous with no evidence of extracutaneous manifestations after complete staging has been performed. The major categories of primary cutaneou…

Therapeutic Strategies in Dermatology

Vascular Birthmarks: Clinical Cases

…, obstructing vision Initial evaluation Clinical diagnosis: hemangioma of infancy Given rapid growth, visual impediment with potential impairment of visual development, treatment is implemented Prednisone 1 mg/kg/day started (note: propranolol woul…