Differential Diagnosis in Dermatopathology

Spitz’s nevus, compound type vs. Melanoma

Papules, nodules, and tumors that, on gross examination, are usually skin colored and, on histopathologic examination, consist of an epithelium-lined sac that contains fluid, cells, or both in the case of true cysts and of cysts that are associated…

Dermatology Practical & Conceptual

Spitz and Reed nevi: acquired or congenital?

…as constituents of combined nevi in association with blue or Spitz nevi [1]. Here, in our opinion, the putative Clark nevus most likely corresponds to an associated Unna or Ackerman nevus, respectively, as the melanocytes are either confined to the…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Blue Nevus?

…all of them are constituted of melanocytes. If a melanocytic nevus must consist of nests and fascicles of melanocytes, and at times of columns, cords, and strands of them, then “common” blue nevus, unlike “cellular” blue nevu…

Dermatology Practical & Conceptual

Blue nevus with a starburst pattern on dermoscopy

…e coloration [3]. Blue globules and dots, and pigment network-like structures are also observed in some cases of blue nevus [4]. On the other hand, Spitz nevi usually present as solitary lesions on the lower extremities or the face. Clinically, a Spi…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Nevus?

…acquired proliferation of melanocytes known as a melanocytic nevus, e.g., Clark’s, Spitz’s, and Reed’s. That condition is not a hamartoma, but a benign neoplasm. Both congenital melanocytic nevi and acquired melanocytic nevi are co…

Dermatology Practical & Conceptual

Melanoma arising in a giant nevus spilus maculosus

…of multiple dark-brown macules on a light brown, cafÉ-au-lait-like background (Figure 4). A punch biopsy of the nevus showed elongation of rete ridges and hyperpigmentation of basal keratinocytes but no substantial proliferation of melanocytes (Figur…