Differential Diagnosis in Dermatopathology

Dermatofibroma vs. Desmoplastic Spitz’s nevus

Papules, nodules, and tumors that, on gross examination, are usually skin colored and, on histopathologic examination, consist of an epithelium-lined sac that contains fluid, cells, or both in the case of true cysts and of cysts that are associated…

Differential Diagnosis in Dermatopathology

Spitz’s nevus, compound type vs. Melanoma

Papules, nodules, and tumors that, on gross examination, are usually skin colored and, on histopathologic examination, consist of an epithelium-lined sac that contains fluid, cells, or both in the case of true cysts and of cysts that are associated…

Dermatology Practical & Conceptual

Spitz and Reed nevi: acquired or congenital?

…as constituents of combined nevi in association with blue or Spitz nevi [1]. Here, in our opinion, the putative Clark nevus most likely corresponds to an associated Unna or Ackerman nevus, respectively, as the melanocytes are either confined to the…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Blue Nevus?

…all of them are constituted of melanocytes. If a melanocytic nevus must consist of nests and fascicles of melanocytes, and at times of columns, cords, and strands of them, then “common” blue nevus, unlike “cellular” blue nevu…

Dermatology Practical & Conceptual

Blue nevus with a starburst pattern on dermoscopy

…e coloration [3]. Blue globules and dots, and pigment network-like structures are also observed in some cases of blue nevus [4]. On the other hand, Spitz nevi usually present as solitary lesions on the lower extremities or the face. Clinically, a Spi…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Nevus?

…acquired proliferation of melanocytes known as a melanocytic nevus, e.g., Clark’s, Spitz’s, and Reed’s. That condition is not a hamartoma, but a benign neoplasm. Both congenital melanocytic nevi and acquired melanocytic nevi are co…

Dermatology Practical & Conceptual

Melanoma arising in a giant nevus spilus maculosus

…of multiple dark-brown macules on a light brown, cafÉ-au-lait-like background (Figure 4). A punch biopsy of the nevus showed elongation of rete ridges and hyperpigmentation of basal keratinocytes but no substantial proliferation of melanocytes (Figur…