Therapeutic Strategies in Dermatology

Histiocytosis X/Langerhans Cell Histiocytoses

…compose the folliculosebaceous-apocrine germ in an embryo and that usually manifests clinically as a papule or nodule which may become ulcerated. On the basis of clinico-pathologic correlation, five distinctive types of basal cell carcinoma have bee…

A Clinical Atlas of 101 Common Skin Diseases

Lymphomas (Other Than Mycosis Fungoides and Lymphomatoid Papulosis)

…e usually occurs as a solitary, rapidly growing tumor. Most of the neoplastic lymphocytes express the CD30 antigen. Panniculitis-like T-cell lymphoma is a distinct type derived from activated cytotoxic T-cells and characterized by plaques and subcuta…

Therapeutic Strategies in Dermatology

Cutaneous T-Cell Lymphoma/ Mycosis Fungoides: Overview

Overview Therapy of cutaneous T-cell lymphoma often requires specialized knowledge, and for this reason it is often appropriate to refer such patients to a medical center with specialized knowledge in the management of CTCL. Since early aggressive t

Therapeutic Strategies in Dermatology

Histiocytosis X/Langerhans Cell Histiocytoses: Overview

Overview Langerhans cell histiocytoses (Class I histiocytosis) are a group of disorders most common in childhood due to the accumulation or proliferation of a clonal population of cells bearing the phenotype of a Langerhans cell that has been arrest

Therapeutic Strategies in Dermatology

Lymphomatoid Papulosis: Overview

…outine and regular evaluations are required. Any lesion of LyP that continues to enlarge and does not autoinvolute must be biopsied to rule out the development of anaplastic CD30+ large cell lymphoma. Oral bexarotene may be associated with hypothyroi…

Therapeutic Strategies in Dermatology

Kaposi’s Sarcoma: Overview

…ns. Ulceration and secondary infection are not infrequent, and they require aggressive therapy with antibiotics for infection or cellulitis and local dressings. Low-dose interferon alpha, 3 million units three times weekly, is well tolerated and over…

Histologic Diagnosis of Inflammatory Skin Diseases

Subcutaneous T-cell lymphoma

…chanism responsible for it. Immunophenotyping has demonstrated the neoplastic cells to be T lymphocytes. Comment Cytophagic panniculitis, the name used synonymously for subcutaneous T-cell lymphoma, is a misnomer; it is not an inflammatory disease of…

Histologic Diagnosis of Inflammatory Skin Diseases

Subcutaneous T-cell lymphoma

…e usually occurs as a solitary, rapidly growing tumor. Most of the neoplastic lymphocytes express the CD30 antigen. Panniculitis-like T-cell lymphoma is a distinct type derived from activated cytotoxic T-cells and characterized by plaques and subcuta…

Therapeutic Strategies in Dermatology

Pemphigus Vulgaris: Overview

teroids with cyclophosphamide may be used in refractory cases. Treatment of the underlying disorder may be beneficial. This includes removal of any underlying carcinoma or thymoma, chemotherapy for underlying lymphoma, and rituximab or alemtuzumab fo…

Therapeutic Strategies in Dermatology

Vascular Birthmarks: Key Points

thmarks defines cutaneous HOI as benign, self-limited vascular tumors that present early in infancy and spontaneously involute typically within the first few years of life. They are typically comprised of endothelial cells (staining GLUT-1 positive o…