Search Results for: subcutaneous t-cell lymphoma

Therapeutic Strategies in Dermatology

Histiocytosis X/Langerhans Cell Histiocytoses

A malignant neoplasm made up of abnormal germinative cells analogous to those that compose the folliculosebaceous-apocrine germ in an embryo and that usually manifests clinically as a papule or nodule which may become ulcerated. On the basis of…

A Clinical Atlas of 101 Common Skin Diseases

Lymphomas (Other Than Mycosis Fungoides and Lymphomatoid Papulosis)

lymphoma with preferential location on the head and back, immunocytoma (and marginal-zone lymphoma) situated on the trunk, buttocks, and extremities, and large B-cell lymphoma with predilection for the legs of older patients. Cutaneous Tcell

Therapeutic Strategies in Dermatology

Histiocytosis X/Langerhans Cell Histiocytoses: Overview

…ne marrow are very poor prognostic signs. Skin-limited cases and sometimes systemic disease may spontaneously involute without therapy. Disease may recur after involution, even years later; therefore long-term follow-up is essential. Langerhans cell

Therapeutic Strategies in Dermatology

Lymphomatoid Papulosis: Overview

…Individual lesions resolve spontaneously (albeit over months). Patients with LyP are at increased risk to develop cutaneous Tcell lymphoma and systemic lymphoma of many types. The treatment of LyP does not prevent progression or the development of…

Therapeutic Strategies in Dermatology

Cutaneous T-Cell Lymphoma/ Mycosis Fungoides: Overview

…supplied in 20-mg vials; 10 ml of 95% alcohol is added to each, dissolved, and saved as 0.2% carmustine stock solution. A cotton-tipped applicator is used to apply the stock solution directly to each lesion twice daily for 2 weeks; therapy may be…

Therapeutic Strategies in Dermatology

Vascular Birthmarks: Key Points

…rare cases, HOI may become highly inflammatory, ulcerate, or impose hemodynamic instability due to extensive size; in the setting of symptomatic HOI or ones involving the face or mucosal site, immediate intervention may be required. Facial HOI,…

Therapeutic Strategies in Dermatology

Pemphigus Vulgaris & Paraneoplastic Pemphigus: Treatment

the disease activity, therapy is aimed at both resolution of cutaneous lesions and elimination of circulating antibody. The titers of the circulating anti-epithelial cell surface IgG (via IIF) or anti-desmoglein 1 and 3 antibodies (via ELISA)…

Therapeutic Strategies in Dermatology

Lupus: Key Points

…of systemic lupus erythematosus (SLE) may have specific or non-specific features. Specific cutaneous signs include malar (butterfly) facial rash, discoid skin lesions, oral ulcers, and photosensitivity, especially in combination with systemic…

Therapeutic Strategies in Dermatology

Granuloma Annulare: Key Points

…ulare (GA) is a relatively common inflammatory skin condition, which can manifest with cutaneous eruptions in a handful of patterns. GA tends to occur in the third to fifth decades of life, with a roughly equal female: male ratio with perhaps a…

Histologic Diagnosis of Inflammatory Skin Diseases

Subcutaneous T-cell lymphoma

…ird and fourth decades of life Distribution of lesions Extremities, trunk, face, neck, and breasts Arrangement of lesions Scattered or in clusters Configuration of lesions Round Individual lesions Plaques and nodules Variations clinical Fever,…