Therapeutic Strategies in Dermatology

Histiocytosis X/Langerhans Cell Histiocytoses

A malignant neoplasm made up of abnormal germinative cells analogous to those that compose the folliculosebaceous-apocrine germ in an embryo and that usually manifests clinically as a papule or nodule which may become ulcerated. On the basis of clin…

A Clinical Atlas of 101 Common Skin Diseases

Lymphomas (Other Than Mycosis Fungoides and Lymphomatoid Papulosis)

type usually occurs as a solitary, rapidly growing tumor. Most of the neoplastic lymphocytes express the CD30 antigen. Panniculitis-like T-cell lymphoma is a distinct type derived from activated cytotoxic T-cells and characterized by plaques and sub…

Therapeutic Strategies in Dermatology

Cutaneous T-Cell Lymphoma/ Mycosis Fungoides: Overview

Overview Therapy of cutaneous T-cell lymphoma often requires specialized knowledge, and for this reason it is often appropriate to refer such patients to a medical center with specialized knowledge in the management of CTCL. Since early aggressive t

Therapeutic Strategies in Dermatology

Histiocytosis X/Langerhans Cell Histiocytoses: Overview

Overview Langerhans cell histiocytoses (Class I histiocytosis) are a group of disorders most common in childhood due to the accumulation or proliferation of a clonal population of cells bearing the phenotype of a Langerhans cell that has been arrest

Therapeutic Strategies in Dermatology

Lymphomatoid Papulosis: Overview

…aracterized by the presence of CD30-positive lymphocytes (sometimes large and atypical) in the dermal infiltrate. Individual lesions resolve spontaneously (albeit over months). Patients with LyP are at increased risk to develop cutaneous T-cell lymph…

Therapeutic Strategies in Dermatology

Kaposi’s Sarcoma: Overview

…ful or disfiguring lesions of the feet, penis, or face. d. Alitretinoin gel 0.1% may be applied to macular lesions. e. Subsequently, for patients with stage II-A disease and helper T-cell counts over 200/mm3, intramuscular or subcutaneous A2 interfer…

Therapeutic Strategies in Dermatology

Pemphigus Vulgaris: Overview

…ut steroid or immunosuppressive therapy. Closely follow patients for clinical complications of immunosuppression and high-dose steroid therapy. Paraneoplastic Pemphigus Paraneoplastic pemphigus is associated with an underlying malignancy (usually ly…

Therapeutic Strategies in Dermatology

Vascular Birthmarks: Key Points

…amilies, and will best define treatment options as necessary. This distinction is also important because other vascular birthmarks may represent a manifestation of a syndrome with extracutaneous involvement or may be symptomatic lesions with deep sub…

Therapeutic Strategies in Dermatology

Lupus: Key Points

…stemic disease, only the management of more common forms of cutaneous lupus will be discussed here. The four forms of cutaneous lupus discussed are: discoid lupus, subacute cutaneous lupus, lupus profundus, and bullous lupus. Subcutaneous lupus may b…

Therapeutic Strategies in Dermatology

Granuloma Annulare: Key Points

…a reactive inflammatory skin condition, which commonly presents as annular pink, erythematous thin plaques on the distal extremities. Granuloma annulare usually presents as localized disease, generalized plaques or papules, or subcutaneous nodules….