Dermatology Practical & Conceptual

Epidermal multinucleated giant cells are not always a histopathologic clue to a herpes virus infection: multinucleated epithelial giant cells in the epidermis of lesional skin biopsies from patients with acantholytic dermatoses can histologically mimic a herpes virus infection

Abstract Background: Multinucleated giant cells in the epidermis can either be epithelial or histiocytic. Epithelial multinucleated giant cells are most often associated with herpes virus infections. Purpose: To review the histologic differential di…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Basal-Cell Carcinoma Common in Nevus Sebaceus?

“Nevus sebaceus may be ‘programmed’ for or susceptible to the eventual development of a variety of neoplasms that generally occur in adulthood. The most common of these is basal cell carcinoma, which develops in 5% to 7% of the l…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Pseudomalignancies?

“The term pseudocancerosis covers a variety of diseases that can be difficult to distinguish from true carcinomas not only clinically but also histologically. However, pseudocanceroses may not only be similar to squamous cell carcinomas but a…

Clinical Case Studies

Multiple Trichoepitheliomas

…t on her nose and chin. (Figure 1A, B). Figure 1A. Multiple trichoepitheliomas predominantly on the midface. Figure 1B. Multiple trichoepitheliomas. The patient was treated with dermabrasion in the 1980s, which was relatively unsuccessful. She…

Differential Diagnosis in Dermatopathology

Discussions

In general, neoplasms metastatic to the skin present little difficulty in differential diagnosis from neoplasms primary in the skin. Carcinoma of the breast is an exception. If there are but a few neoplastic cells and numerous inflammatory cells sca…