Therapeutic Strategies in Dermatology

Urticaria Pigmentosa/ Mastocytosis: Overview

Overview Mastocytosis results from systemic or localized mast cell proliferation. The natural history and pathogenesis of cases occurring in childhood (before age 2) and cases occurring in adults is distinctly different. Childhood cases are usually…

Therapeutic Strategies in Dermatology

Chondrodermatitis Nodularis Helicis: Key Points

Key points Chondrodermatitis nodularis helicis (CNH) is an uncommon, strikingly painful lesion on the helix or antihelix of the ear, which often appears as a crusted ulceration mimicking a cutaneous malignancy. Diagnosis may be made by clinical exa…

Therapeutic Strategies in Dermatology

Tuberculosis, Cutaneous: Overview

Overview Cutaneous tuberculosis includes all forms of tuberculosis affecting the skin-those in which organisms can be identified (tuberculous ulcer, scrofuloderma, orificial tuberculosis, tuberculosis verrucosa cutis, and lupus vulgaris) as well as…

Therapeutic Strategies in Dermatology

Porokeratosis: Overview

Overview The etiology of this disorder is unknown and therapy is empiric. Treatment First steps Topical 5-fluorouracil (5-FU) 5% cream applied once or twice daily to lesions, until the epidermis desquamates and a crust forms, will often resolve sup…

Therapeutic Strategies in Dermatology

Pyoderma Gangrenosum: Key Points

Key Points Pyoderma gangrenosum is a type of ulcerating neutrophilic dermatosis. The classic morphology of pyoderma gangrenosum is an ulcer with a violaceous rim and undermined border. PG lesions may develop very rapidly (in days) and may be trigg…

Therapeutic Strategies in Dermatology

Necrobiosis Lipoidica Diabeticorum: Overview

…al of 3 treatments at 0, 2, and 6 weeks. NLD has a tendency to ulcerate. These ulcerations may be infected by bacteria, so nonhealing lesions should be cultured, and appropriate topical and oral antibiotics should be considered if the methods outline…

Therapeutic Strategies in Dermatology

Balanitis: Overview

Overview Balanitis is a nonspecific term meaning inflammation of the glans penis. It is most commonly multifactorial in etiology, restricted to the uncircumcised, and presents as a mildly symptomatic scaly, red macule or patch. Acute suppurative bal…

Therapeutic Strategies in Dermatology

Spider Bites: Treatment

Treatment Spider bites of Loxosceles reclusa First steps First-line therapy involves localized wound care. Elevate and rest the bitten area. Apply ice, not heat. Give analgesics as needed for pain. The use of systemic agents such as dapsone or cor…

Therapeutic Strategies in Dermatology

Granuloma Inguinale: Overview

Overview This sexually transmitted disease is caused by the gram-negative bacterium Klebsiella granulomatis. Treatment is directed against the causative microorganism. Treatment First Steps Azithromycin 1 gram orally once weekly for 6 weeks, or unti…

Therapeutic Strategies in Dermatology

Herpes Zoster & Varicella: Treatment

Treatment Herpes zoster First-line therapy: The first-line therapy for herpes zoster includes the treatment of the acute eruption and therapy for herpetic neuralgia and post-herpetic neuralgia. Confirmation of herpes zoster by viral direct fluoresc…