Therapeutic Strategies in Dermatology

Bullous Pemphigoid: Overview

…phigoid and may explain atypical therapeutic responses. Immunosuppression may result in reactivation of herpes simplex or varicella zoster virus infection. These bullous infectious diseases may be generalized and simulate a flare of the pemphigoid….

Therapeutic Strategies in Dermatology

Herpes Simplex: Initial Evaluation

…o Herpes zoster is caused by dermatomal reactivation of varicella virus and can also result in grouped clear fluid-to-pus-filled vesicles on an erythematous-to-hemorrhagic base. In most cases of localized zoster, a clear dermatomal distribution…

A Clinical Atlas of 101 Common Skin Diseases

Preface

…classification were arbitrary. For example, we chose to place varicella in a chapter with herpes simplex and zoster, rather than with the other viral exanthems, some of which also are vesicular, e.g., hand, foot, and mouth disease caused by Coxsackie…

Therapeutic Strategies in Dermatology

Erythema Multiforme: Key Points

Key Points Erythema multiforme (EM) is a clinical syndrome marked by either target lesions and/or mucosal erosions. It may be idiopathic or seen in association with infections or medications. EM has been reported in association with herpes simplex…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Lymphocytic Vasculitis?

…videnced.” Uhoda I, Pierard-Franchimont C, Pierard GE. Varicella-zoster virus vasculitis: a case of recurrent varicella without epidermal involvement. Dermatology 2000;200:173–75. “Outside the context of hereditary deficiencies o…

Histologic Diagnosis of Inflammatory Skin Diseases

Impetigo contagiosa

…iant of impetigo contagiosa. Differential diagnosis clinical Varicella is vesicular, rather than pustular or bullous, and favors the trunk. Herpes simplex may mimic impetigo, particularly when the contents of vesicles become turbid, but lesions tend…

Dermatology Practical & Conceptual

Epidermal multinucleated giant cells are not always a histopathologic clue to a herpes virus infection: multinucleated epithelial giant cells in the epidermis of lesional skin biopsies from patients with acantholytic dermatoses can histologically mimic a herpes virus infection

…iral cultures were negative for both herpes simplex virus and varicella-zoster virus. Repeat skin biopsies were performed for routine staining and direct immunofluorescence. Figure 3. Enlargement and/or rupture of pustules and vesicles in the righ…

Differential Diagnosis in Dermatopathology

Discussions

…iseases brought into being by herpesvirus, namely, zoster and varicella. Changes nearly identical to those in cowpox are seen in smallpox. The large pox (i.e., syphilis) is unrelated wholly to smallpox and cowpox. Clinically, lesions of herpes simple…

Differential Diagnosis in Dermatopathology

Herpes simplex vs. Vaccinia

…classification were arbitrary. For example, we chose to place varicella in a chapter with herpes simplex and zoster, rather than with the other viral exanthems, some of which also are vesicular, e.g., hand, foot, and mouth disease caused by Coxsackie…

Histologic Diagnosis of Inflammatory Skin Diseases

Farmyard pox

…y methods electron microscopic and virologic. Herpes simplex, varicella, and zoster are characterized by marked ballooning, reticular alteration, and intraepidermal vesicles, but those changes are joined by acantholytic cells, multinucleate epithelia…