Therapeutic Strategies in Dermatology

Bullous Pemphigoid: Overview

Overview Bullous pemphigoid is usually a self-limited inflammatory subepidermal blistering disorder of the elderly, in which circulating auto antibodies to epitopes in the basement membrane zone bind to this region and initiate a cascade of inflamma…

Therapeutic Strategies in Dermatology

Herpes Simplex: Initial Evaluation

Initial Evaluation Herpes simplex may result in painful or burning crusted grouped vesicles near the mouth or nares, often recurrent in the same location. Grouped (herpetiform) pustular lesions resulting in erosions with scalloped borders are sugges…

A Clinical Atlas of 101 Common Skin Diseases

Preface

What prompted the undertaking of this pocket atlas of dermatology? The reasons were several and varied, among them the following: 1. ¬†Pictures are and always have been an extraordinarily valuable vehicle in the study of clinical dermatology. The fir…

Therapeutic Strategies in Dermatology

Erythema Multiforme: Key Points

Key Points Erythema multiforme (EM) is a clinical syndrome marked by either target lesions and/or mucosal erosions. It may be idiopathic or seen in association with infections or medications. EM has been reported in association with herpes simplex…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Lymphocytic Vasculitis?

…evidenced.” Uhoda I, Pierard-Franchimont C, Pierard GE. Varicella-zoster virus vasculitis: a case of recurrent varicella without epidermal involvement. Dermatology 2000;200:173–75. “Outside the context of hereditary deficiencies…

Histologic Diagnosis of Inflammatory Skin Diseases

Impetigo contagiosa

Impetigo contagiosa Synonyms Impetigo Presentation stereotypical Age and sex Children, particularly of preschool age, but young adults of either sex may be affected Distribution of lesions Exposed parts of the body, especially the face, hands, neck,…

Differential Diagnosis in Dermatopathology

Herpes simplex vs. Vaccinia

What prompted the undertaking of this pocket atlas of dermatology? The reasons were several and varied, among them the following: 1. ¬†Pictures are and always have been an extraordinarily valuable vehicle in the study of clinical dermatology. The fir…

Differential Diagnosis in Dermatopathology

Discussions

As their names denote, herpes simplex is caused by a herpesvirus and cowpox (vaccinia) by a poxvirus. Both are DNA viruses that induce lesions in the skin that share many findings histopathologic, e.g., intraepidermal vesicles surrounded by balloone…

Dermatology Practical & Conceptual

Epidermal multinucleated giant cells are not always a histopathologic clue to a herpes virus infection: multinucleated epithelial giant cells in the epidermis of lesional skin biopsies from patients with acantholytic dermatoses can histologically mimic a herpes virus infection

Abstract Background: Multinucleated giant cells in the epidermis can either be epithelial or histiocytic. Epithelial multinucleated giant cells are most often associated with herpes virus infections. Purpose: To review the histologic differential di…

Histologic Diagnosis of Inflammatory Skin Diseases

Farmyard pox

Farmyard pox Synonyms Barnyard pox Presentation stereotypical Age and sex No predilection for age, but more common among men who are herders of sheep (orf) and cows (milker’s nodule), and in veterinarians Distribution of lesions Fingers especi…