Therapeutic Strategies in Dermatology

Superficial Fungal Infections: Therapy: Tinea versicolor

Therapy: Tinea versicolor Tinea versicolor is a superficial skin infection by Malassezia furfur (a.k.a. Pityrosporum ovale and Pityrosporum orbiculare). Epidemiology Tinea versicolor is a very common skin infection, affecting up to 2-8% individuals…

Therapeutic Strategies in Dermatology

Dermatitis Herpetiformis: Treatment

Treatment First-line therapy:  The first-line therapy for DH is oral dapsone once each day (100 mg daily dose). Dapsone should be started after G6PD screening is performed. A dramatic clinical response is expected within 4-5 days. Reevaluate the pa…

Histologic Diagnosis of Inflammatory Skin Diseases

Vitiligo

Vitiligo Synonyms Achroma vitiligo Presentation stereotypical Age and sex Young adults and women especially Distribution of lesions Localized, segmental, or widespread; often symmetric Individual lesions Macules and patches Course Protracted usually…

Histologic Diagnosis of Inflammatory Skin Diseases

Vitiligo

An inflammatory process that is idiopathic and results in depigmentation of the skin consequent to loss of melanocytes from the epidermis, and in whitening of hair that follows loss of melanocytes from the bulb of follicles….

Therapeutic Strategies in Dermatology

Melanoma: Treatment

Treatment Initial therapy First-line therapy: Surgical excision For diagnosis, complete excisional biopsy with minimal margins, pathologically evaluated at multiple levels to determine the tumor thickness, as well as to determine presence of ulcera…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Halo Phenomenon?

…in the wake of that process is indistinguishable from that of vitiligo (not surprisingly, about 25 percent of persons with halo nevi have concurrent vitiligo). Much more often than not, regression of melanoma is partial, not complete, and the altera…

Histologic Diagnosis of Inflammatory Skin Diseases

Images

…ytes in foci of subtle spongiosis as well as around a venule = Vitiligo  In an early lesion of vitiligo, such as the one shown here, lymphocytes are present in the upper part of the dermis and in the epidermis, where they induce a tad of spongiosis,…

Histologic Diagnosis of Inflammatory Skin Diseases

Applicable Terms

ABSCESS [L. abscessus (a going away)]: Clinically, a circumscribed collection of pus and histopathologically a localized collection of neutrophils. An abscess may form in the epidermis, both surface and infundibular, eccrine ducts, dermis, and subcu…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Blaschkitis?

“Blaschkite de l’adulte is considered a new disease entity . . . described by Grosshans and Marot in their report of relapsing acquired unilateral skin lesions following Blaschko’s lines.” Megahed et al. Acquired relapsing…