Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Ichthyoses?

…Dermatol 1966;94:113–26. “There are four major types of ichthyosis: ichthyosis vulgaris, X-linked ichthyosis, ichthyosis congenita and epidermolytic hyperkeratosis (bullous ichthyosiform erythroderma). In addition, there are several rare syndr…

Histologic Diagnosis of Inflammatory Skin Diseases

Non-bullous congenital ichthyosiform erythroderma

…oderma not related to any of the so-called ichthyoses, such as ichthyosis vulgaris, X-linked ichthyosis, and lamellar ichthyosis, but the exact nosologic status of it still is on debate. For sure it is an inflammatory process, in contradistinction to…

Differential Diagnosis in Dermatopathology

Discussions

Ichthyosis vulgaris and X-linked ichthyosis are true ichthyoses in the sense that the clinical appearance of their scales resembles vaguely those of fish (In Greek, ichthos means fish, and -osis means a condition of). As in all ichthyoses, the scale…

Histologic Diagnosis of Inflammatory Skin Diseases

Applicable Terms

…ation is met with in the stratum corneum of conditions such as ichthyosis vulgaris and X-linked ichthyosis, thin plates of corneocytes in those conditions being disposed parallel to the skin surface, as well as to one another. Laminated orthokeratosi…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Blaschkitis?

…of Blaschko become manifest in heterozygous states of various X-linked gene defects, such as incontinentia pigmenti, X-linked hypohidrotic ectodermal dysplasia, and focal dermal hypoplasia. For Happle it is evident that a direct relationship exists…

Histologic Diagnosis of Inflammatory Skin Diseases

Epidermis

…erol coincides with desquamation of corneocytes. Patients with X-linked ichthyosis lack steroid sulfatase, that absence preventing removal of cholesterol sulfate and, thereby, limiting shedding of corneocytes, resulting in hyperkeratosis that is refl…

Dermatology Practical & Conceptual

Study By Disease

…itiligo (Quiz #502) Wegener’s granulomatosis (Quiz #890) X-linked ichthyosis (Quiz #501) Xanthogranuloma (Quiz #106) Xanthogranuloma (Quiz #735) Zitelli’s nevus (superficial and “deep” congenital nevus) (Quiz #744) ZitelliR…

Differential Diagnosis in Dermatopathology

Images

Ichthyosis vulgaris X-linked ichthyosis

Differential Diagnosis in Dermatopathology

Differential Diagnosis

Ichthyosis vulgaris X-linked ichthyosis 1. Cornified layer thickened, but less than half the thickness of the viable epidermis 1. Cornified layer thickened and often at least half the thickness of the viable epidermis 2. Lamellate and basket-w…