Histologic Diagnosis of Inflammatory Skin Diseases

Miescher’s granuloma of the face

…d (elastotic) skin. Arch Dermatol 1975;111:460–66. Steffen C. Actinic granuloma (O’Brien). J Cutan Pathol 1988;15:66–74. Tock CL, Cohen PR. Annular elastolytic giant cell granuloma. Cutis 1998;62:181–87. Wilson-Jones E. Necrobiosis lipoidica pr…

Histologic Diagnosis of Inflammatory Skin Diseases

Images

…ed with elastophagocytosis is given a different name, to wit, actinic granuloma. 10.15.2A: Nodular dermatitis, granulomatous + 10.15.2B: Histiocytes in palisaded array around foci of degenerated collagen and necrosis of inflammatory cells i…

Histologic Diagnosis of Inflammatory Skin Diseases

Images

…2B: A band of histiocytes, some of them multinucleate, around squamous epithelium that, in turn, surrounds cellulose = Foreign body reaction to a splinter The splinter came to be surrounded by squamous epithelium by virtue of epidermis, either surfac…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Epidermal Cyst and Epidermoid Cyst?

…n is the epidermal cyst which is lined entirely by stratified squamous epithelium usually without skin appendages. . . . These cysts may arise from hair follicles, sebaceous ducts, and from the epidermis, and it is usually impossible to determine the…

Differential Diagnosis in Dermatopathology

Photoallergic dermatitis vs. Phototoxic dermatitis

An inflammatory, i.e., granulomatous, process that usually takes the form of papules which in constellation often assume annular, arcuate, and serpiginous shapes. Many variants exist, among them widespread papules, papules in photodistribution, papu…

Differential Diagnosis in Dermatopathology

Discussions

…of the superficial plexus, infiltrates of mixed inflammatory cells, erythrocytes extravasated in variable numbers in the papillary dermis and sometimes in the epidermis, tendency to both intra- and subepidermal vesiculation, edema of the papillary d…

Histologic Diagnosis of Inflammatory Skin Diseases

Lupus erythematosus

…sic discoid lupus erythematosus. Bullous lupus erythematosus: Actinic prurigo, a manifestation of polymorphous light eruption, tends to be crusted, but rarely is frankly vesicular or bullous. Hydroa aestivale favors the face, rather than the upper pa…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Atrophoderma?

…8211; Focal dermal hypoplasia Acquired skin atrophies – Actinic (senile) skin atrophy – Inanition atrophy – Traction and pressure atrophy – Anetodermas – Neurogenic skin atrophy – Atrophodermia vermiculata –…

Histologic Diagnosis of Inflammatory Skin Diseases

Dermatomyositis

…yositis, atrophic lichen planus, and disseminated superficial actinic porokeratosis. A distinctly smudged appearance of the dermoepidermal interface is a clue to discoid lupus erythematosus and dermatomyositis. A thickened epidermal basement membrane…