Histologic Diagnosis of Inflammatory Skin Diseases

Images

…that happens, the condition should not then be called “actinic granuloma”; it still is granuloma annulare. 10.43.7A: Nodular dermatitis, granulomatous + 10.43.7B: Histiocytes in palisaded array around a locus replete with mucin…

Histologic Diagnosis of Inflammatory Skin Diseases

Granuloma annulare

…it has been accorded a place apart in this subchapter. “Actinic granuloma” consists of annular plaques of granuloma annulare situated on skin damaged badly by sunlight. Differential diagnosis clinical Sarcoidosis may be annular, especia…

Histologic Diagnosis of Inflammatory Skin Diseases

Our Definition of “Inflammation” and “Inflammatory Disease”

…ically as a reaction to injury of any kind (e.g., mechanical, actinic, chemical, allergic, infectious, and effects of neoplasms) and characterized clinically by redness and swelling especially, and histopathologically by vasodilation and infiltrates…

Histologic Diagnosis of Inflammatory Skin Diseases

Collagen

…I collagen. Together, Types I and III collagen form the extracellular fibers that are responsible largely for the tensile strength of the dermis. Mutations in genes in Types I and III collagen may result in abnormalities of connective tissue both in…

Histologic Diagnosis of Inflammatory Skin Diseases

Images

…ed with elastophagocytosis is given a different name, to wit, actinic granuloma. 10.15.2A: Nodular dermatitis, granulomatous + 10.15.2B: Histiocytes in palisaded array around foci of degenerated collagen and necrosis of inflammatory cells i…

Histologic Diagnosis of Inflammatory Skin Diseases

Miescher’s granuloma of the face

…d (elastotic) skin. Arch Dermatol 1975;111:460–66. Steffen C. Actinic granuloma (O’Brien). J Cutan Pathol 1988;15:66–74. Tock CL, Cohen PR. Annular elastolytic giant cell granuloma. Cutis 1998;62:181–87. Wilson-Jones E. Necrobiosis lipoidica pr…

Histologic Diagnosis of Inflammatory Skin Diseases

Images

…2B: A band of histiocytes, some of them multinucleate, around squamous epithelium that, in turn, surrounds cellulose = Foreign body reaction to a splinter The splinter came to be surrounded by squamous epithelium by virtue of epidermis, either surfac…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Epidermal Cyst and Epidermoid Cyst?

…n is the epidermal cyst which is lined entirely by stratified squamous epithelium usually without skin appendages. . . . These cysts may arise from hair follicles, sebaceous ducts, and from the epidermis, and it is usually impossible to determine the…

Differential Diagnosis in Dermatopathology

Discussions

…of the superficial plexus, infiltrates of mixed inflammatory cells, erythrocytes extravasated in variable numbers in the papillary dermis and sometimes in the epidermis, tendency to both intra- and subepidermal vesiculation, edema of the papillary d…