Histologic Diagnosis of Inflammatory Skin Diseases

Images

…ted with elastophagocytosis is given a different name, to wit, actinic granuloma. 10.15.2A: Nodular dermatitis, granulomatous + 10.15.2B: Histiocytes in palisaded array around foci of degenerated collagen and necrosis of inflammatory cells…

Histologic Diagnosis of Inflammatory Skin Diseases

Collagen

More than 70% of the dry weight of the normal dermis consists of collagen (Fig. 1.79). The major collagens are Type I and Type III. Type I collagen has a molecular mass of about 290 KDa and accounts for approximately 80% of the total amount of colla…

Histologic Diagnosis of Inflammatory Skin Diseases

Our Definition of “Inflammation” and “Inflammatory Disease”

…pathologically by vasodilation and infiltrates of inflammatory cells, those especially being neutrophils, eosinophils, lymphocytes, plasma cells, and histiocytes. Inflammatory Disease. A disorder characterized histopathologically by an infiltrate o…

Histologic Diagnosis of Inflammatory Skin Diseases

Miescher’s granuloma of the face

…lare spectrum. Arch Dermatol 1973;107:62–64. O’Brien JP. Actinic granuloma. An annular connective tissue disorder affecting sun- and heat-damaged (elastotic) skin. Arch Dermatol 1975;111:460–66. Steffen C. Actinic granuloma (O’Brien). J C…

Histologic Diagnosis of Inflammatory Skin Diseases

Images

…12B: A band of histiocytes, some of them multinucleate, around squamous epithelium that, in turn, surrounds cellulose = Foreign body reaction to a splinter The splinter came to be surrounded by squamous epithelium by virtue of epidermis, either surfa…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Epidermal Cyst and Epidermoid Cyst?

“Epidermoid cyst. Synonym: Sebaceous cyst, steatoma, epithelial cyst. Definition: A cyst containing keratin and its breakdown products, surrounded by an epidermoid wall.” Mackie RM. Epidermal skin tumors. In: Champion RH, Burton JL, Eb…

Histologic Diagnosis of Inflammatory Skin Diseases

Porphyria cutanea tarda

Porphyria cutanea tarda Presentation stereotypical Age and sex Young and middle-aged adults of both sexes, but mainly women taking estrogens or who are alcoholic Distribution of lesions Blisters on dorsa of hands and feet, pigmentary alterations and…

Differential Diagnosis in Dermatopathology

Discussions

…gstanding photoallergic dermatitis. The face of a patient with actinic reticuloid often resembles that of a lion (leonine), as does that of some patients with lymphoma or leukemia and, stereotypically, those with lepromatous leprosy. In brief, actini…

Differential Diagnosis in Dermatopathology

Photoallergic dermatitis vs. Phototoxic dermatitis

An inflammatory, i.e., granulomatous, process that usually takes the form of papules which in constellation often assume annular, arcuate, and serpiginous shapes. Many variants exist, among them widespread papules, papules in photodistribution, papu…