Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Mucha-Habermann Disease a Lymphocytic Vasculitis?

…i in the lumen in the context of an infiltrate of inflammatory cells. In the vast majority of instances, the cells are neutrophils, e.g., in leukocytoclastic vasculitis, septic vasculitis, and livedo vasculitis. Rarely, lymphocytes monopolize the inf…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Spongiform Pustular Diseases?

“The pustule I have designated spongiform (spongelike) was markedly and impressively seen in acrodermatitis continua of Hallopeau. It is composed of leukocytes that have migrated into the soaked epidermis, destroying epithelial cells by inva…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Perivasculitis?

…both together in the context of an infiltrate of inflammatory cells. The definition of vasculitis of small vessels in skin is different from that of vasculitis of large vessels in the subcutaneous fat, in which the presence of inflammatory cells in…

Dermatology Practical & Conceptual

Glomangiosarcoma in the shoulder of a 51-year-old man

…as performed. Histopathological findings Shave biopsy showed a cellular neoplasm with a multinodular growth pattern in the dermis (Figure 1A). The neoplasm was very cellular and consisted of round, ovoid and spindle cells with moderate nuclear atypia…

Histologic Diagnosis of Inflammatory Skin Diseases

Crohn’s disease

…ease. Arch Dermatol 1982;118:1006–09. McLelland J, Griffin SM. Metastatic Crohn’s disease of the umbilicus. Clin Exp Dermatol 1996;21:318–9. Shum DT, Guenther L. Metastatic Crohn’s disease. Case report and review of the literature. Arch D…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Wide and Deep Excision for Melanoma?

…1 micron, will ensure cure, i.e., the person will never die of metastatic melanoma. If, however, a melanoma, no matter how thin, already has metastasized by the time the neoplasm is excised in toto, the patient is likely doomed to die of metastatic m…

Differential Diagnosis in Dermatopathology

Discussions

…clear abnormalities that may simulate vaguely the kind seen in squamous-cell carcinoma. Of the three major patterns of seborrheic keratoses, namely, acanthotic, adenoid (reticulate), and verrucous, only the acanthotic type presents a problem in diffe…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Parapsoriasis?

“Parapsoriasis. Under this provisional name, Brocq in 1902 grouped several rare and unclassifiable dermatological types, characterized by nonpruriginous erythmato-squamous spots, extremely persistent and rebellious to all treatment. It is ex…

Histologic Diagnosis of Inflammatory Skin Diseases

Sebaceous Units

…cally looks like a cloak composed of cords of undifferentiated cells is seen in sections oriented horizontally to be a skirt that encircles the follicle. At puberty, in response to endogenous androgens, those undifferentiated epithelial cells prolife…