Histologic Diagnosis of Inflammatory Skin Diseases

Epidermolysis bullosa simplex

…asm of epidermal basal cells and no infiltrate of inflammatory cells in the dermis Fully developed Dermal papillae preserved beneath what seems, at first blush, to be a subepidermal blister Vacuoles in epidermal basal cells at the sides of the blis…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Dermal and Epidermal Types of Erythema Multiforme?

…ermal edema resulting in intradermal bulla formation, with the basal lamina at the top of the blister. (b) ‘Target’ lesions showed primarily epidermal damage resulting in bulla formation at the dermal-epidermal junction with the basal lam…

Histologic Diagnosis of Inflammatory Skin Diseases

Dystrophic epidermolysis bullosa

…Vacuoles beneath the epidermis No infiltrate of inflammatory cells Fully developed Subepidermal blister Little or no infiltrate of inflammatory cells Late Fibroplasia in the upper part of the dermis Subepidermal clefts above the scar sometimes…

Differential Diagnosis in Dermatopathology

Differential Diagnosis

Metastatic carcinoma from a breast Morpheiform basal-cell carcinoma 1. Strands, cords, and columns of neoplastic epithelial cells in the dermis 1. Cords and columns of neoplastic epithelial cells in the dermis; no strands as a rule 2. Differen…

Differential Diagnosis in Dermatopathology

Images

Metastatic carcinoma from a breast Morpheiform basal-cell carcinoma

Differential Diagnosis in Dermatopathology

Erythroderma of psoriasis vs. Erythroderma of mycosis fungoides

A disease manifested chiefly in the skin by vesicles and bullae that appear on sites of trauma, especially the face and dorsa of the hands, often in conjunction with macular hyperpigmentation and hypertrichosis of a face and sclerodermoid changes on…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Epidermal Cyst and Epidermoid Cyst?

“Epidermoid cyst. Synonym: Sebaceous cyst, steatoma, epithelial cyst. Definition: A cyst containing keratin and its breakdown products, surrounded by an epidermoid wall.” Mackie RM. Epidermal skin tumors. In: Champion RH, Burton JL, Eb…