Histologic Diagnosis of Inflammatory Skin Diseases

Lupus erythematosus

…culitis made up mostly of lymphocytes but also often of plasma cells; nuclear “dust” of lymphocytes (“tangible bodies”) sometimes prominent Patchy sclerosis in association with the infiltrate of mononuclear cells, giving the a…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Atrophoderma?

“Atrophoderma, or atrophia cutis. Atrophy of the skin may be quantitative or qualitative; idiopathic or symptomatic; diffused or circumscribed. Crocker gives this useful table: Pigmentosum Juvenilis Albidum Diffusum Senilis…

Histologic Diagnosis of Inflammatory Skin Diseases

Dermatomyositis

Dermatomyositis Presentation stereotypical Age and sex Children or adults; in adults, tending to occur more commonly in women in their fifth or sixth decade Distribution of lesions Widespread, at first on the eyelids, then the entire face, eventuall…

Histologic Diagnosis of Inflammatory Skin Diseases

Lipodystrophy

Lipodystrophy Synonyms Lipoatrophy Wucher atrophy Presentation stereotypical Age and sex Females, first decade of life Distribution of lesions Upper half of body in the “partial” expression of the process and widespread in the “t…

Histologic Diagnosis of Inflammatory Skin Diseases

Definition of Inflammation in Historical Perspective

…until 1859, however, that Rudolf Virchow, in his classic work, Cellularpathologie, advised that “inflammation is the most common pathologic process in tissue caused by a stimulus that evokes changes in cellular parts of the tissue, which might…

Dermatology Practical & Conceptual

Inguinal porokeratosis in a Japanese man

Abstract Inguinal and genital porokeratosis is rare but seems to be more common in Asians. We report a case of a 69-year-old Japanese man with multiple lesions of porokeratosis in both inguinal regions. The lesions first appeared in the inguinal reg…

Histologic Diagnosis of Inflammatory Skin Diseases

Images

Images 10.2.1A: Perivascular dermatitis, spongiotic and slightly psoriasiform + 10.2.1B: Slight edema of the papillary dermis and scale-crust = Nummular dermatitis ┬áChanges such as these are indistinguishable from those of allergic contac…

Histologic Diagnosis of Inflammatory Skin Diseases

Atopic dermatitis

Atopic dermatitis Synonyms Neurodermatitis Atopic eczema Presentation stereotypical Age and sex All ages and both sexes; in infants, children, and young adults who are atopic and in whom the signs of rubbing and scratching tend to be distributed on…

Differential Diagnosis in Dermatopathology

Papular mucinosis vs Interstitial granuloma annulare

An inflammatory, i.e., granulomatous, process that usually takes the form of papules which in constellation often assume annular, arcuate, and serpiginous shapes. Many variants exist, among them widespread papules, papules in photodistribution, papu…