Differential Diagnosis in Dermatopathology

Photoallergic dermatitis vs. Phototoxic dermatitis

An inflammatory process that results from either topical or systemic sensitization coupled with the effects of ultraviolet light. The lesions, all of which occur in photodistribution, are macules, papules, and blisters that resolve with crusts….

Histologic Diagnosis of Inflammatory Skin Diseases

Lupus erythematosus

…sic discoid lupus erythematosus. Bullous lupus erythematosus: Actinic prurigo, a manifestation of polymorphous light eruption, tends to be crusted, but rarely is frankly vesicular or bullous. Hydroa aestivale favors the face, rather than the upper pa…

Histologic Diagnosis of Inflammatory Skin Diseases


…yositis, atrophic lichen planus, and disseminated superficial actinic porokeratosis. A distinctly smudged appearance of the dermoepidermal interface is a clue to discoid lupus erythematosus and dermatomyositis. A thickened epidermal basement membrane…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology


…8211; Focal dermal hypoplasia Acquired skin atrophies – Actinic (senile) skin atrophy – Inanition atrophy – Traction and pressure atrophy – Anetodermas – Neurogenic skin atrophy – Atrophodermia vermiculata –…

Histologic Diagnosis of Inflammatory Skin Diseases


…plex chronicus, is known also as persistent light eruption or actinic reticuloid, it, fundamentally, being a photoallergic dermatitis of long standing that has been rubbed vigorously and also for long. 10.2.7A: Vesicular dermatitis, intraepider…

Histologic Diagnosis of Inflammatory Skin Diseases


…tiocytes mostly in lobules Lymphocytes and, sometimes, plasma cells scattered among the histiocytes Some histiocytes with foamy cytoplasm Fibrosis amid the granulomatous infiltrate in lesions resolving Correlation clinicopathologic As a consequence…

Dermatology Practical & Conceptual

Inguinal porokeratosis in a Japanese man

…ncluding the plaque type of Mibelli, disseminated superficial actinic porokeratosis (some lesions of this type are distributed mainly in areas not exposed to the sun or appear in patients on immunosuppressants), linear porokeratosis, porokeratosis pl…

Histologic Diagnosis of Inflammatory Skin Diseases

Definition of Inflammation in Historical Perspective

…ntil 1859, however, that Rudolf Virchow, in his classic work, Cellularpathologie, advised that “inflammation is the most common pathologic process in tissue caused by a stimulus that evokes changes in cellular parts of the tissue, which might b…

Differential Diagnosis in Dermatopathology


…al findings histopathologic in common, among them mesenchymal cells with abundant pink cytoplasm scattered among bundles of collagen, multinucleate cells in sections of tissue of some specimens, deposits of mucin in company with an increased number o…