Differential Diagnosis in Dermatopathology

Nodular scabies vs. Lymphomatoid papulosis

Loss of hair attributable either to the effects of inflammatory cells on follicles or to physiological or mechanical factors in which inflammatory cells play no role. Although the scalp is the site most often affected, any region of the skin that be…

Differential Diagnosis in Dermatopathology

Mucha-Habermann disease vs. Secondary syphilis

Loss of hair attributable either to the effects of inflammatory cells on follicles or to physiological or mechanical factors in which inflammatory cells play no role. Although the scalp is the site most often affected, any region of the skin that be…

Histologic Diagnosis of Inflammatory Skin Diseases

Lymphocytoma cutis

…involuting without therapy Variations clinical Simulators of B-cell lymphoma, e.g., Lymphomatoid drug reaction, such as that induced by antirheumatic medications and by cyclosporine
Persistent reactions to arthropod assaults, such as those of ticks…

Differential Diagnosis in Dermatopathology

Lymphomatoid papulosis vs. Mycosis fungoides, plaque

Loss of hair attributable either to the effects of inflammatory cells on follicles or to physiological or mechanical factors in which inflammatory cells play no role. Although the scalp is the site most often affected, any region of the skin that be…

Differential Diagnosis in Dermatopathology

Discussions

…ic between Mucha-Habermann disease and secondary syphilis may be difficult because the two diseases have so many attributes in common. Both may be associated with a superficial and deep perivascular and lichenoid infiltrate of mononuclear cells, acan…

Histologic Diagnosis of Inflammatory Skin Diseases

Borreliosis (erythema migrans)

…to specific diagnosis histopathologic An infiltrate that resembles a response to an insect “bite,” but that includes plasma cells is a clue to erythema chronicum migrans. A “lymphocytic infiltrate” that displays plasma cells,…

Histologic Diagnosis of Inflammatory Skin Diseases

Images

….97.1A: Perivascular and interstitial dermatitis + 10.97.1B: Neutrophils, eosinophils, lymphocytes, and plasma cells in the interstitium of the reticular dermis = Morphea, early  The changes shown represent an early stage in a longstanding inflam…

Histologic Diagnosis of Inflammatory Skin Diseases

Mucha-Habermann disease

…hologic Lymphomatoid papulosis is associated with unquestionably abnormal lymphocytes, some of which usually are in mitosis, and often with a mix of inflammatory cells. Erythema multiforme does not show prominent parakeratosis or scale-crust, and th…