Histologic Diagnosis of Inflammatory Skin Diseases

Sebaceous Units

…cally looks like a cloak composed of cords of undifferentiated cells is seen in sections oriented horizontally to be a skirt that encircles the follicle. At puberty, in response to endogenous androgens, those undifferentiated epithelial cells prolife…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Keratosis Lichenoides Chronica?

…erences between them histopathologically, namely, inflammatory cells around follicles and irregular epidermal growth in the former, and inflammatory cells only in dermal papillae with partial atrophy of the epidermis in the latter. In the same articl…

Dermatology Practical & Conceptual

Pigmented Lesions

…507, 508, 509) An epidermis thickened by two populations of cells, namely, pigmented “basaloid” ones with scant cytoplasm that make up the bulk of the lesion and nearly non-pigmented “squamoid” cells with copious cytoplasm…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Recurrence of Melanoma?

“Traditionally, local recurrence of melanoma is considered to be the appearance of melanoma foci within 5 cm of the primary excision site. This includes metastatic melanoma involving the primary excision site, satellites, and intransit metast…

Differential Diagnosis in Dermatopathology

Differential Diagnosis

Metastatic carcinoma from a breast Morpheiform basal-cell carcinoma 1. Strands, cords, and columns of neoplastic epithelial cells in the dermis 1. Cords and columns of neoplastic epithelial cells in the dermis; no strands as a rule 2. Differen…

Differential Diagnosis in Dermatopathology

Images

Metastatic carcinoma from a breast Morpheiform basal-cell carcinoma

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Epidermal Cyst and Epidermoid Cyst?

“Epidermoid cyst. Synonym: Sebaceous cyst, steatoma, epithelial cyst. Definition: A cyst containing keratin and its breakdown products, surrounded by an epidermoid wall.” Mackie RM. Epidermal skin tumors. In: Champion RH, Burton JL, Eb…

Histologic Diagnosis of Inflammatory Skin Diseases

Images

…12B: A band of histiocytes, some of them multinucleate, around squamous epithelium that, in turn, surrounds cellulose = Foreign body reaction to a splinter The splinter came to be surrounded by squamous epithelium by virtue of epidermis, either surfa…

Histologic Diagnosis of Inflammatory Skin Diseases

See Classification of Pigmented Lesions

…ke keratosis Seborrheic keratosis Malignant neoplasms Basal cell carcinoma, pigmented Solar keratosis, pigmented Melanocytic lesions Benign Melanosis Simple lentigo Nevus of Ota, nevus of Ito Nevi Congenital Classic acral Superficial Super…