Search Results for: metastatic squamous-cell carcinoma

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Mucha-Habermann Disease a Lymphocytic Vasculitis?

…racterized by the presence of fibrin in the wall and/or thrombi in the lumen in the context of an infiltrate of inflammatory cells. In the vast majority of instances, the cells are neutrophils, e.g., in leukocytoclastic vasculitis, septic…

Nab-paclitaxel-associated photosensitivity: report in a woman with non-small lung cancer and review of taxane-related photodermatoses

Nab-paclitaxel-associated photosensitivity: report in a woman with non-small lung cancer and review of taxane-related photodermatoses

…erapy [7]. Paclitaxel-induced erythema multiforme on sun-exposed skin has previously been observed. A 40-year-old woman with metastatic breast cancer presented with photodistributed erythema multiforme and onycholysis following treatment with…

Dermoscopic clues to diagnose acantholytic dyskeratosis

Dermoscopic clues to diagnose acantholytic dyskeratosis

…nied by several dermatologic adverse events [1]. These include both benign and malignant lesions, such as cutaneous squamouscell carcinoma, verrucal keratosis, plantar hyperkeratosis, hair follicle changes, panniculitis, and photosensitivity [2],…

A quiz from Manaus, Brazil

A quiz from Manaus, Brazil

…h CD34 are also seen [12]. Solitary fibrous tumor (SFT) of the skin is a very uncommon lesion consisting of alternating hypercellular and hypocellular areas of bland spindle cells, arranged in a combination of fascicular, storiform and…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Perivasculitis?

…h Dermatol 1985;121:1442–44. “Granulomas of the sarcoid type with numerous foreign body and Langhans’ giant cells were the dominating features [of metastatic Crohn’s disease]. In accordance with previous results, we found…

Glomangiosarcoma in the shoulder of a 51-year-old man

Glomangiosarcoma in the shoulder of a 51-year-old man

…Shave biopsy showed a cellular neoplasm with a multinodular growth pattern in the dermis (Figure 1A). The neoplasm was very cellular and consisted of round, ovoid and spindle cells with moderate nuclear atypia and frequent mitotic figures (up to 6…

Histologic Diagnosis of Inflammatory Skin Diseases

Crohn’s disease

…ne N, Bangert J. Cutaneous granulomatosis in Crohn’s disease. Arch Dermatol 1982;118:1006–09. McLelland J, Griffin SM. Metastatic Crohn’s disease of the umbilicus. Clin Exp Dermatol 1996;21:318–9. Shum DT, Guenther L. Metastatic

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Wide and Deep Excision for Melanoma?

…atter how thin, already has metastasized by the time the neoplasm is excised in toto, the patient is likely doomed to die of metastatic melanoma irrespective of how wide and deep the margins of excision. In short, the width and breadth of excision…

Gajewski TF, Hodi FS. Targeted Therapeutics in Melanoma. New York: Springer, 2012

Gajewski TF, Hodi FS. Targeted Therapeutics in Melanoma. New York: Springer, 2012

…mmunotherapeutics, discussed in Part III, include melanoma antigens recognized by T lymphocytes, melanoma vaccines, adoptive cell therapy for treatment of metastatic melanoma, anti-CTLA-4 monoclonal antibodies, anti PD-1 and anti B7-H1/PD-L1…

Differential Diagnosis in Dermatopathology

Discussions

…of “squamous eddies” to development of nuclear abnormalities that may simulate vaguely the kind seen in squamouscell carcinoma. Of the three major patterns of seborrheic keratoses, namely, acanthotic, adenoid (reticulate), and…