Search Results for: metastatic squamous-cell carcinoma

A quiz from Manaus, Brazil

A quiz from Manaus, Brazil

…h CD34 are also seen [12]. Solitary fibrous tumor (SFT) of the skin is a very uncommon lesion consisting of alternating hypercellular and hypocellular areas of bland spindle cells, arranged in a combination of fascicular, storiform and…

Glomangiosarcoma in the shoulder of a 51-year-old man

Glomangiosarcoma in the shoulder of a 51-year-old man

…Shave biopsy showed a cellular neoplasm with a multinodular growth pattern in the dermis (Figure 1A). The neoplasm was very cellular and consisted of round, ovoid and spindle cells with moderate nuclear atypia and frequent mitotic figures (up to 6…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Perivasculitis?

…h Dermatol 1985;121:1442–44. “Granulomas of the sarcoid type with numerous foreign body and Langhans’ giant cells were the dominating features [of metastatic Crohn’s disease]. In accordance with previous results, we found…

Histologic Diagnosis of Inflammatory Skin Diseases

Crohn’s disease

…ne N, Bangert J. Cutaneous granulomatosis in Crohn’s disease. Arch Dermatol 1982;118:1006–09. McLelland J, Griffin SM. Metastatic Crohn’s disease of the umbilicus. Clin Exp Dermatol 1996;21:318–9. Shum DT, Guenther L. Metastatic

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Wide and Deep Excision for Melanoma?

…atter how thin, already has metastasized by the time the neoplasm is excised in toto, the patient is likely doomed to die of metastatic melanoma irrespective of how wide and deep the margins of excision. In short, the width and breadth of excision…

Gajewski TF, Hodi FS. Targeted Therapeutics in Melanoma. New York: Springer, 2012

Gajewski TF, Hodi FS. Targeted Therapeutics in Melanoma. New York: Springer, 2012

…mmunotherapeutics, discussed in Part III, include melanoma antigens recognized by T lymphocytes, melanoma vaccines, adoptive cell therapy for treatment of metastatic melanoma, anti-CTLA-4 monoclonal antibodies, anti PD-1 and anti B7-H1/PD-L1…

Differential Diagnosis in Dermatopathology

Discussions

…of “squamous eddies” to development of nuclear abnormalities that may simulate vaguely the kind seen in squamouscell carcinoma. Of the three major patterns of seborrheic keratoses, namely, acanthotic, adenoid (reticulate), and…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Keratosis Lichenoides Chronica?

…at despite the unity of the two diseases, there were some differences between them histopathologically, namely, inflammatory cells around follicles and irregular epidermal growth in the former, and inflammatory cells only in dermal papillae with…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Parapsoriasis?

…ermatosis, which has also been called fingerprint parapsoriasis or digitate parapsoriasis.” Gibson LE, Perry HO. Papulosquamous eruptions and exfoliative dermatitis. In: Moschella SL, Hurley HJ, eds. Dermatology, 3rd ed. Philadelphia: W. B….

Systematic review of diagnostic accuracy of reflectance confocal microscopy for melanoma diagnosis in patients with clinically equivocal skin lesions

Systematic review of diagnostic accuracy of reflectance confocal microscopy for melanoma diagnosis in patients with clinically equivocal skin lesions

…ival with higher stage is because the only potentially curative treatment is surgical excision [5]. Adjuvant therapy for non-metastatic melanoma has not yet been demonstrated to provide a survival benefit [6] and no therapy has proven to extend…