Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Nuclear Atypia, Cytoplasmic Atypia, and Architectural Atypia?

“The cytologically atypical melanocytes have the same features as cytologically atypical cells in any neoplastic system. Such cells are larger than normal melanocytes or the intraepidermal melanocytes of an ordinary melanocytic nevus.”…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Eccrine Neoplasms?

Classification of Skin Appendage Tumors Eccrine Differentiation Eccrine nevus Eccrine duct proliferation Eccrine-centered nevus Eccrine angiomatous hamartoma Syringofibroadenoma or acrosyringeal nevus Comedo nevus of the palm, linear eccrine nevu…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Eccrine, Apocrine, and Apoeccrine Sweat Glands?

“Evidence is presented that in adult human axillae there exists a third type of sweat gland tentatively designated as the apoeccrine sweat gland. This type of gland shows a segmental or diffuse apocrinelike dilatation of its secretory tubule…

Dermatology Practical & Conceptual

Papillary adenocarcinoma in situ of the skin: report of four cases

Abstract Although rare isolated cases of adenocarcinoma in situ of skin have been reported in the literature, adenocarcinoma in situ of skin as a concept and as a diagnostic category has not been established in the field of dermatopathology. In this…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Metastasizing Dermatofibroma?

“. . . We conclude that dermatofibromas can very rarely metastasize. Risk factors for metastasis may include relatively large size, high cellularity, and local recurrence. It would appear that metastasizing dermatofibromas behave in an indol…

Histologic Diagnosis of Inflammatory Skin Diseases

Rosacea

Rosacea Synonyms Gutta rosea Presentation stereotypical Age and sex Young and middle-aged adults, usually Caucasian women Distribution of lesions Center of the face in vertical and horizontal directions, i.e., nose, forehead, cheeks, and chin Indivi…

Histologic Diagnosis of Inflammatory Skin Diseases

Junctional epidermolysis bullosa

…gnosis histopathologic Other cell-poor subepidermal blistering diseases, such as a suction blister, cell-poor pemphigoid, and one expression of acquired epidermolysis bullosa; all of these “cell poor” blistering diseases may be indistingu…

Differential Diagnosis in Dermatopathology

Urticarial reaction to an arthropod assault vs. Urtica

An inflammatory process caused by superficial fungi, i.e., fungi situated superficially in the cornified layer and in other cornified structures, and expressed clinically as smooth-surfaced papules, scaly papules, scaly plaques, nodules, pustules, v…

Differential Diagnosis in Dermatopathology

Discussions

…light eruption. Biopsy of the hive-like lesions in those four diseases produces a specimen from which sections of tissue display changes diagnostic of a specific disease, ones very different from findings in urtica. Subtle differences histopathologi…

Histologic Diagnosis of Inflammatory Skin Diseases

Acne vulgaris

Synonyms Acne simplex Presentation stereotypical Age and sex Adolescents of both sexes; usually more severe in males. May affect neonates. Distribution of lesions Regions in which large sebaceous units are joined to vellus follicles, i.e., the face,…