Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Toxic Erythema?

…les FC, Corson EF, Decker HB. Types of lesions in common skin diseases. In: Diseases of the Skin, 4th ed. Philadelphia, PA: Lea & Febiger, 1942:37. “Toxic erythema is a poorly defined clinical entity in which there is a macular or blotchy…

Histologic Diagnosis of Inflammatory Skin Diseases


…Bibliography Bibliography for viral exanthems Alsop J, et al. Hand-foot-mouth disease in Birmingham. Br Med J 1959;2:1708. Barnadas MA, Alegre M, Baselga E, Randazzo L, Margall N, et al. Histopathological changes of primary HIV infection: description…

Dermatology Practical & Conceptual

Papillary adenocarcinoma in situ of the skin: report of four cases

…excised with a positive margin, and there was no evidence of disease progression at the six-year follow-up. The photomicrographs of H&E and P63 stain provided by the authors for their case (figures 2 and 3 in the article) showed clearly the pres…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Metastasizing Dermatofibroma?

…uni et al. told of a patient with a lesion on the dorsum of a foot less than 1.5 centimeters in diameter, which was diagnosed by conventional microscopy as “fibrous histiocytoma.” The lesion recurred at the local site three times first wi…

Histologic Diagnosis of Inflammatory Skin Diseases

Junctional epidermolysis bullosa

…tissue, C-shaped plaques that sweep around the angles of the mouth, extracutaneous involvement common, often lethal in the first months of life; a number of subtypes are differentiated from one another on the basis of features clinical. Pyloric atre…

Histologic Diagnosis of Inflammatory Skin Diseases


…ocular dermatitis consists of papules and pustules around the mouth and eyes of young women especially. Blepharitis occurs episodically and may be followed by conjunctivitis and keratitis. Lupus miliaris disseminatus faciei is a papular variant of gr…

Histologic Diagnosis of Inflammatory Skin Diseases

Granuloma annulare

…n or young adults as deep-situated nodules, especially on the hands and buttocks, and in the pretibial region. Perforating granuloma annulare presents itself usually on the dorsa of hands as tiny umbilicated papules topped by crusts. Widespread granu…

Differential Diagnosis in Dermatopathology

Urticarial reaction to an arthropod assault vs. Urtica

…les may be centered in follicles (Majocchi’s granuloma). Lesions may occur on any anatomic site, but particularly on the scalp (tinea capitis), inguinal region (tinea cruris), hands (tinea manum), feet (tinea pedis), and nails (onychomycosis)….

Differential Diagnosis in Dermatopathology


…light eruption. Biopsy of the hive-like lesions in those four diseases produces a specimen from which sections of tissue display changes diagnostic of a specific disease, ones very different from findings in urtica. Subtle differences histopathologic…