Differential Diagnosis in Dermatopathology

Nodular scabies vs. Lymphomatoid papulosis

A systemic lymphoma of T-lymphocytes that manifests itself first in the skin as macules and then patches that often are scaly. Most people with the disease have only scaly macules and patches for a lifetime, but some patients may develop papules, pl…

Histologic Diagnosis of Inflammatory Skin Diseases

Paraneoplastic pemphigus

…patches, or papules; rarely vesicles; oral erosions secondary to vesiculation Course Variable, but often persisting as long as the underlying neoplastic process goes unchecked Variations clinical Lymphoma or leukemia often is severe and results in…

Differential Diagnosis in Dermatopathology

Discussions

…of some large lymphocytes, extravasated erythrocytes, edema of the papillary dermis, dilated venules and capillaries, cells of the infiltrate present sometimes in the upper part of the subcutaneous fat, spongiosis and spongiotic vesiculation, epiderm…

Dermatology Practical & Conceptual

A reticulated pigmented rash on the lower leg

…sed by sleeping on hot bricks) and kengri cancer (seen only in the Kashmir region of India and caused by wearing a heater pot under the clothes). Cases of Merkel cell carcinoma and marginal zone lymphoma have also been described with these lesions [7…

Differential Diagnosis in Dermatopathology

Discussions

…ists. Photoallergic dermatitis and phototoxic dermatitis share the following attributes histopathologic: perivascular infiltrates that involve at least the vessels of the superficial plexus, infiltrates of mixed inflammatory cells, erythrocytes extra…

Differential Diagnosis in Dermatopathology

Photoallergic dermatitis vs. Phototoxic dermatitis

A systemic lymphoma of T-lymphocytes that manifests itself first in the skin as macules and then patches that often are scaly. Most people with the disease have only scaly macules and patches for a lifetime, but some patients may develop papules, pl…

Histologic Diagnosis of Inflammatory Skin Diseases

Granuloma faciale

…Correlation clinicopathologic Papules, plaques, nodules, and tumors are formed of dense nodular mixed-cell infiltrates in the reticular dermis and, sometimes, in the upper part of the subcutaneous fat. The dusky hue is due to prominent dilation of…

Histologic Diagnosis of Inflammatory Skin Diseases

Lichen striatus

…elium and the dermis Some multinucleate histiocytes present in the papillary dermis Acanthosis, sometimes psoriasiform Necrotic keratocytes disposed as individual units and often in clusters near the base of the epidermis; sometimes those cells prese…

Dermatology Practical & Conceptual

European dermatology: great past-no future?

…cine, like internal medicine or surgery. We still bear some of this basic mistrust, and we bare our teeth when we see our dominance over melanoma, lymphoma, autoimmune diseases and many other disorders threatened. Interestingly, the rise of dermatolo…