Histologic Diagnosis of Inflammatory Skin Diseases

Identification of Basic Patterns: Skin: Fibrosing Dermatitis

…54 A&B. Signs indicative of the cause of chondrodermatitis nodularis helicis: external trauma. What is called chondrodermatitis nodularis helicis simply is a response to injury by pressure sustained on a helix, the result being ulceration and gra…

Histologic Diagnosis of Inflammatory Skin Diseases

Images

Images 10.63.1A: Perivascular dermatitis, interface, vacuolar + 10.63.1B: Smudged appearance of the dermoepidermal junction, focally thinned epidermis, and plentiful mucin throughout the dermis = Lupus erythematosus, discoid ┬áThe presence…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Acquired Epidermolysis Bullosa?

…microscopy 2. Demonstration of blister formation beneath the basal lamina, which remains on the epidermal side of the blister by electron microscopy 3. Deposition of IgG in the amorphous zone beneath the basal lamina, demonstrable by immunoelectr…

Histologic Diagnosis of Inflammatory Skin Diseases

Nerves

…liam Montagna, Ph.D.) Unmyelinated axons surrounded by Schwann cells are arrayed in a branching and overlapping network. Many of the unmyelinated axons terminate near the dermoepidermal junction, where basal lamina of their Schwann cells make contact…

Dermatology Practical & Conceptual

Melanoma arising in a giant nevus spilus maculosus

…evus showed elongation of rete ridges and hyperpigmentation of basal keratinocytes but no substantial proliferation of melanocytes (Figure 5). Histopathology of the nodule showed a nodular melanoma with an invasion thickness of 4.5 mm (Figure 6). On…

Histologic Diagnosis of Inflammatory Skin Diseases

Epidermolysis bullosa simplex

…asm of epidermal basal cells and no infiltrate of inflammatory cells in the dermis Fully developed Dermal papillae preserved beneath what seems, at first blush, to be a subepidermal blister Vacuoles in epidermal basal cells at the sides of the blis…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Parapsoriasis?

“Parapsoriasis. Under this provisional name, Brocq in 1902 grouped several rare and unclassifiable dermatological types, characterized by nonpruriginous erythmato-squamous spots, extremely persistent and rebellious to all treatment. It is ex…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Dermal and Epidermal Types of Erythema Multiforme?

…ermal edema resulting in intradermal bulla formation, with the basal lamina at the top of the blister. (b) ‘Target’ lesions showed primarily epidermal damage resulting in bulla formation at the dermal-epidermal junction with the basal lam…

Histologic Diagnosis of Inflammatory Skin Diseases

Dystrophic epidermolysis bullosa

…Vacuoles beneath the epidermis No infiltrate of inflammatory cells Fully developed Subepidermal blister Little or no infiltrate of inflammatory cells Late Fibroplasia in the upper part of the dermis Subepidermal clefts above the scar sometimes…

Histologic Diagnosis of Inflammatory Skin Diseases

Rosacea

…onventionally, it is divided into telangiectatic, papular, and nodular stages, the papular being synonymous with “granulomatous” rosacea and the nodular with rhinophyma. There also is a pustular manifestation of rosacea, it being a suppur…