Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Dermal and Epidermal Types of Erythema Multiforme?

…ermal edema resulting in intradermal bulla formation, with the basal lamina at the top of the blister. (b) ‘Target’ lesions showed primarily epidermal damage resulting in bulla formation at the dermal-epidermal junction with the basal lam…

Histologic Diagnosis of Inflammatory Skin Diseases

Dystrophic epidermolysis bullosa

…Vacuoles beneath the epidermis No infiltrate of inflammatory cells Fully developed Subepidermal blister Little or no infiltrate of inflammatory cells Late Fibroplasia in the upper part of the dermis Subepidermal clefts above the scar sometimes…

Histologic Diagnosis of Inflammatory Skin Diseases

Rosacea

…onventionally, it is divided into telangiectatic, papular, and nodular stages, the papular being synonymous with “granulomatous” rosacea and the nodular with rhinophyma. There also is a pustular manifestation of rosacea, it being a suppur…

Differential Diagnosis in Dermatopathology

Erythroderma of psoriasis vs. Erythroderma of mycosis fungoides

Mammary Paget’s disease is an apocrine carcinoma that begins in mammary glands and extends along lactiferous ducts to the epidermis where it is seen clinically as a scaly, crusted, or eroded plaque on the nipple or areola of women mostly, and…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Lentigo Maligna?

“Melanoma arising from lentigo maligna is preceded by or forms a part of a recognizable series of events affecting the melanocytic cellular system in a way similar to these stages. First, there is a long period characterized by an increase in…

Histologic Diagnosis of Inflammatory Skin Diseases

Pattern Analysis in Historical Perspective

…sis morphologically of the (1) patterns formed by inflammatory cells, sometimes in conjunction with changes in epidermal and adnexal epithelium, and the (2) character of the inflammatory cells themselves. Although algorithms were utilized in the appl…

Histologic Diagnosis of Inflammatory Skin Diseases

Kimura’s disease

…roliferation of small blood vessels lined by plump endothelial cells throughout the dermis Correlation clinicopathologic The nodules and tumors are constituted of dense nodular and diffuse infiltrates of lymphocytes, some of them in lymphoid follicl…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Epidermal Cyst and Epidermoid Cyst?

“Epidermoid cyst. Synonym: Sebaceous cyst, steatoma, epithelial cyst. Definition: A cyst containing keratin and its breakdown products, surrounded by an epidermoid wall.” Mackie RM. Epidermal skin tumors. In: Champion RH, Burton JL, Eb…