Histologic Diagnosis of Inflammatory Skin Diseases

Epidermolysis bullosa simplex

…asm of epidermal basal cells and no infiltrate of inflammatory cells in the dermis Fully developed Dermal papillae preserved beneath what seems, at first blush, to be a subepidermal blister Vacuoles in epidermal basal cells at the sides of the blis…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Acquired Epidermolysis Bullosa?

…microscopy 2. Demonstration of blister formation beneath the basal lamina, which remains on the epidermal side of the blister by electron microscopy 3. Deposition of IgG in the amorphous zone beneath the basal lamina, demonstrable by immunoelectr…

Dermatology Practical & Conceptual

Melanoma arising in a giant nevus spilus maculosus

…evus showed elongation of rete ridges and hyperpigmentation of basal keratinocytes but no substantial proliferation of melanocytes (Figure 5). Histopathology of the nodule showed a nodular melanoma with an invasion thickness of 4.5 mm (Figure 6). On…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Dermal and Epidermal Types of Erythema Multiforme?

…ermal edema resulting in intradermal bulla formation, with the basal lamina at the top of the blister. (b) ‘Target’ lesions showed primarily epidermal damage resulting in bulla formation at the dermal-epidermal junction with the basal lam…

Histologic Diagnosis of Inflammatory Skin Diseases

Dystrophic epidermolysis bullosa

…Vacuoles beneath the epidermis No infiltrate of inflammatory cells Fully developed Subepidermal blister Little or no infiltrate of inflammatory cells Late Fibroplasia in the upper part of the dermis Subepidermal clefts above the scar sometimes…

Histologic Diagnosis of Inflammatory Skin Diseases

Rosacea

…onventionally, it is divided into telangiectatic, papular, and nodular stages, the papular being synonymous with “granulomatous” rosacea and the nodular with rhinophyma. There also is a pustular manifestation of rosacea, it being a suppur…

Differential Diagnosis in Dermatopathology

Erythroderma of psoriasis vs. Erythroderma of mycosis fungoides

Mammary Paget’s disease is an apocrine carcinoma that begins in mammary glands and extends along lactiferous ducts to the epidermis where it is seen clinically as a scaly, crusted, or eroded plaque on the nipple or areola of women mostly, and…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Lentigo Maligna?

“Melanoma arising from lentigo maligna is preceded by or forms a part of a recognizable series of events affecting the melanocytic cellular system in a way similar to these stages. First, there is a long period characterized by an increase in…

Histologic Diagnosis of Inflammatory Skin Diseases

Kimura’s disease

…roliferation of small blood vessels lined by plump endothelial cells throughout the dermis Correlation clinicopathologic The nodules and tumors are constituted of dense nodular and diffuse infiltrates of lymphocytes, some of them in lymphoid follicl…