Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Acquired Epidermolysis Bullosa?

…80 percent of those patients had infiltrates of inflammatory cells in blisters. No laboratory technique had been capable of differentiating acquired epidermolysis bullosa from bullous pemphigoid until electron microscopy and immunoelectron microscop…

Histologic Diagnosis of Inflammatory Skin Diseases

Nerves

…acks of lamellae. When viewed by electron microscopy, laminar cells are noted to possess a basal lamina and, at the periphery of a corpuscle, to be separated from one another by collagen fibers, elastic fibers, and fibrillary intercellular material….

Histologic Diagnosis of Inflammatory Skin Diseases

Dystrophic epidermolysis bullosa

…Vacuoles beneath the epidermis No infiltrate of inflammatory cells Fully developed Subepidermal blister Little or no infiltrate of inflammatory cells Late Fibroplasia in the upper part of the dermis Subepidermal clefts above the scar sometimes E…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Dermal and Epidermal Types of Erythema Multiforme?

…rmal edema resulting in intradermal bulla formation, with the basal lamina at the top of the blister. (b) ‘Target’ lesions showed primarily epidermal damage resulting in bulla formation at the dermal-epidermal junction with the basal lami…

Histologic Diagnosis of Inflammatory Skin Diseases

Rosacea

…erivascular infiltrates of lymphocytes and, sometimes, plasma cells Suppuration in some infundibula Well-circumscribed collections of epithelioid histiocytes, usually in peri-infundibular location; granulomas surrounded usually by lymphocytes and, so…

Differential Diagnosis in Dermatopathology

Erythroderma of psoriasis vs. Erythroderma of mycosis fungoides

Extramammary Paget’s disease is an apocrine carcinoma that begins within the epidermis and presents itself clinically as a patch or a subtle plaque that extends centrifugally for many years before becoming a readily discernible thick plaque, a…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Lentigo Maligna?

…of a recognizable series of events affecting the melanocytic cellular system in a way similar to these stages. First, there is a long period characterized by an increase in number of structurally normal melanocytes per unit area, which is associated…

Histologic Diagnosis of Inflammatory Skin Diseases

Pattern Analysis in Historical Perspective

…is morphologically of the (1) patterns formed by inflammatory cells, sometimes in conjunction with changes in epidermal and adnexal epithelium, and the (2) character of the inflammatory cells themselves. Although algorithms were utilized in the appli…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Epidermal Cyst and Epidermoid Cyst?

…an involuting follicle well advanced in catagen (exhibiting a basal layer, a pale spinous layer in which “spines” are seen with great difficulty, no granular zone, and compact orthokeratosis), and which is referred to by us as “foll…