Search Results for: nodular basal-cell carcinoma

Dermatology Practical & Conceptual

Melanoma arising in a giant nevus spilus maculosus

…vus showed elongation of rete ridges and hyperpigmentation of basal keratinocytes but no substantial proliferation of melanocytes (Figure 5). Histopathology of the nodule showed a nodular melanoma with an invasion thickness of 4.5 mm (Figure 6). On t…

Histologic Diagnosis of Inflammatory Skin Diseases

Epidermolysis bullosa simplex

…opathologic Early Tiny vacuoles in the cytoplasm of epidermal basal cells and no infiltrate of inflammatory cells in the dermis Fully developed Dermal papillae preserved beneath what seems, at first blush, to be a subepidermal blister Vacuoles in epi…

Histologic Diagnosis of Inflammatory Skin Diseases

Nerves

…acks of lamellae. When viewed by electron microscopy, laminar cells are noted to possess a basal lamina and, at the periphery of a corpuscle, to be separated from one another by collagen fibers, elastic fibers, and fibrillary intercellular material….

Histologic Diagnosis of Inflammatory Skin Diseases

Dystrophic epidermolysis bullosa

…Vacuoles beneath the epidermis No infiltrate of inflammatory cells Fully developed Subepidermal blister Little or no infiltrate of inflammatory cells Late Fibroplasia in the upper part of the dermis Subepidermal clefts above the scar sometimes Epide…

Histologic Diagnosis of Inflammatory Skin Diseases

Rosacea

…erivascular infiltrates of lymphocytes and, sometimes, plasma cells Suppuration in some infundibula Well-circumscribed collections of epithelioid histiocytes, usually in peri-infundibular location; granulomas surrounded usually by lymphocytes and, so…

Differential Diagnosis in Dermatopathology

Erythroderma of psoriasis vs. Erythroderma of mycosis fungoides

Extramammary Paget’s disease is an apocrine carcinoma that begins within the epidermis and presents itself clinically as a patch or a subtle plaque that extends centrifugally for many years before becoming a readily discernible thick plaque, a…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Lentigo Maligna?

…of a recognizable series of events affecting the melanocytic cellular system in a way similar to these stages. First, there is a long period characterized by an increase in number of structurally normal melanocytes per unit area, which is associated…

Histologic Diagnosis of Inflammatory Skin Diseases

Pattern Analysis in Historical Perspective

…is morphologically of the (1) patterns formed by inflammatory cells, sometimes in conjunction with changes in epidermal and adnexal epithelium, and the (2) character of the inflammatory cells themselves. Although algorithms were utilized in the appli…