Differential Diagnosis in Dermatopathology

Psoriasis vs. Nummular dermatitis

An inflammatory process that consists of tiny papules covered by prominent scales and localized typically to the “seborrheic region,” namely, scalp, forehead, eyebrows, malar eminences, paranasal and nasolabial folds, and retroauricular…

Histologic Diagnosis of Inflammatory Skin Diseases

Images

…e from those of allergic contact dermatitis. The psoriasiform acanthosis is more than usually is seen in pityriasis rosea and its lookalike, erythema annulare centrifugum. 10.2.2A: Perivascular dermatitis, spongiotic psoriasiform + 10.2.2B:…

Histologic Diagnosis of Inflammatory Skin Diseases

Toxic shock syndrome

…neutrophils and lymphocytes; tiny abscesses sometimes Slight acanthosis Individual necrotic keratocytes scattered mostly as solitary units in the epidermis Ortho- and parakeratosis Late All the changes seen in lesions developed fully with the addi…

Histologic Diagnosis of Inflammatory Skin Diseases

Gianotti-Crosti disease

…te of lymphocytes Slight edema of the papillary dermis Slight acanthosis Focal spongiosis Fully developed Moderately dense superficial perivascular and interstitial infiltrate of lymphocytes Edema, sometimes extensive, of the papillary dermis Sligh…

Histologic Diagnosis of Inflammatory Skin Diseases

Psoriasis

…dermis Dilated tortuous capillaries in dermal papillae Slight acanthosis Some mitotic figures in keratocytes above the epidermal basal layer Spongiosis in company with a few lymphocytes in discrete foci in the lower part of the epidermis Spongiform a…

Histologic Diagnosis of Inflammatory Skin Diseases

Syphilis

…asis, not only because of the findings shared of psoriasiform acanthosis, pallor in the upper part of the viable epidermis, and an infiltrate of mononuclear cells in the dermis, but also because of the presence at times, in both conditions, of neutro…

Differential Diagnosis in Dermatopathology

Discussions

…arakeratosis that often is accompanied by serum, psoriasiform acanthosis, spongiosis, edema of the papillary dermis, and an infiltrate of lymphocytes mostly around dilated venules of the superficial plexus. The changes histopathologic enumerated here…

Histologic Diagnosis of Inflammatory Skin Diseases

Pityriasis rosea

…te of lymphocytes Slight edema of the papillary dermis Slight acanthosis Slight spongiosis Normal cornified layer with basket-weave configuration Fully developed Superficial perivascular and slightly interstitial infiltrate of lymphocytes Edema of…