Search Results for: alpha-1 antitrypsin deficiency

Therapeutic Strategies in Dermatology

Linear IgA Dermatosis: Overview

…tolerate its side effects of nausea, lethargy, and depression. Use an initial dose of 500 mg twice daily and increase dose by 1 gram every 1-2 weeks until the disease is controlled. Control may require 1-4 gm/day. If partial control is attained with…

Therapeutic Strategies in Dermatology

Angular Cheilitis: Key Points

…ems from chronic maceration by saliva, it is essential to address the ongoing exposure to moisture as part of the treatment plan. Other medical considerations in the differential diagnosis of angular cheilitis include: nutritional deficiency,…

Therapeutic Strategies in Dermatology

Spider Bites: Key Points

…olve cytotoxic factors or inflammatory mediators resulting in inflammation and necrosis of skin. They are summarized in Table 1. Table 1: Spiders and their toxins Common name Characteristic physical features of the spider Toxins contained in the…

Therapeutic Strategies in Dermatology

Flushing: Treatment

…ushing rather than nonspecific therapy (see Shelley WB, Shelley ED: Advanced Dermatologic Therapy, WB Saunders, Philadelphia, 1987, p. 196-201, for a list of various drug interactions and therapies). Highly localized, unilateral, or dermatomal…

Therapeutic Strategies in Dermatology

Rosacea: Key Points

…ushing can alleviate rosacea symptoms. Newer topical treatments provide effective options for treating rosacea subtypes. The alpha adrenergic agonist brimonidine (Mirvaso) effectively reduces erythema in erythemato-telangiectactic rosacea, as well…

Therapeutic Strategies in Dermatology

Sarcoidosis: Treatment

…sarcoidosis. The granulomas frequently convert vitamin D from the inactive form (vitamin D 25) to the active form (vitamin D 1,25), and patients may be hypercalcemic as well. When clinicians screen for vitamin D deficiency, they are often only…

Therapeutic Strategies in Dermatology

Sweet’s Syndrome (Acute Febrile Neutrophil Dermatosis): Treatment

…systemic immunosuppression and/or the use of multiple therapeutic agents in combination. First steps Oral prednisone 0.75 to 1 mg/kg daily will result in a dramatic clinical response in 24-48 hours. The rapid response to prednisone is almost…

Therapeutic Strategies in Dermatology

Livedo / Livedoid Vasculopathy / Atrophie Blanche: Initial Evaluation

…platelet count APLS: Anticardiolipin IgA/G/M, beta-2-glycoproteins IgA/G/M, lupus anticoagulant Factor V Leiden Protein C/S deficiency: activated protein C resistance, protein C functional assay, free protein S antigen assay Prothrombin gene…

Histologic Diagnosis of Inflammatory Skin Diseases

Deficiency diseases

…pathogenesis of psoriasis features an interplay between adaptive and innate immunity centered on interleukin 23 and T-helper 17 cells (IL23/Th17 pathway). Morphologically, psoriasis presents with circumscribed erythematous macules that quickly…