Search Results for: ballooning

Histologic Diagnosis of Inflammatory Skin Diseases

Images

…manifestation referred to as pityriasis lichenoides et varioliformis acuta, which gallops. In the chronica type, there is no ballooning, intraepidermal vesiculation, or neutrophils in mounds of parakeratosis; in fact, spongiosis in slight and the…

Histologic Diagnosis of Inflammatory Skin Diseases

Hand-foot-and-mouth disease

…epidermis beneath a new subepidermal blister whose roof is necrotic Correlation clinicopathologic Tense blisters result from ballooning vesiculation, the gray roof of a blister from confluent necrosis of the epidermis, and the red rim from dilation…

Histologic Diagnosis of Inflammatory Skin Diseases

Algorithms Predicated on “Nonspecific” Findings

…in a blister that began within the epidermis = Blister secondary to effects of electric current, e.g., electrodesiccation + Ballooning intraepidermal vesiculation with epidermal necrosis = Second-degree burn + Eosinophils and sometimes neutrophils…

Histologic Diagnosis of Inflammatory Skin Diseases

Images

…ules, in septic vasculitis thrombi are present in lumen of them. That occlusion results in infarction with subsequent severe ballooning, intraepidermal vesiculation, and epidermal necrosis. The changes pictured here are those of gonococcemia….

Histologic Diagnosis of Inflammatory Skin Diseases

Erythema multiforme

…lymphocytes even may qualify as being lichenoid. When tense vesicles and bullae are biopsied, they may exhibit well-defined ballooning of spinous keratocytes in association with numerous individual necrotic keratocytes. In time, ballooning

Differential Diagnosis in Dermatopathology

Photoallergic dermatitis vs. Phototoxic dermatitis

Papules, nodules, vesicles, and sometimes bullae that develop in response to “bites” of arthropods, among the most common offenders being mosquitoes, bedbugs, and mites of scabies.

Histologic Diagnosis of Inflammatory Skin Diseases

Prurigo pigmentosa

…e dermis and the epidermis; a papulovesicle consists of elements of an urticarial papule with the addition of spongiosis and ballooning; a vesicle develops secondary to extensive ballooning, the color of it sometimes being gray because of necrosis…

Histologic Diagnosis of Inflammatory Skin Diseases

Burns

…hereas a blister induced by sunburn usually occurs with less celerity. Even in a burn early in development, some evidence of ballooning of epidermal keratocytes is discernible. If ballooning is extensive, intraepidermal vesiculation results. If the…

Histologic Diagnosis of Inflammatory Skin Diseases

Pellagra

…s cannot be made without equivocation. Lesions developed fully, however, show pathognomonic changes in the form of extensive ballooning in a band across the upper half of the viable epidermis. Such ballooning is followed always by necrosis and, not…