Histologic Diagnosis of Inflammatory Skin Diseases

Images

Images 10.66.1A: Perivascular dermatitis, interface, vacuolar + 10.66.1B: Lymphocytes along the dermoepidermal junction and in the spinous zone, and ballooned and necrotic keratocytes = Mucha-Habermann disease, acute ┬áThat this lesion is…

Histologic Diagnosis of Inflammatory Skin Diseases

Hand-foot-and-mouth disease

…tes mostly Slight edema of the papillary dermis Spongiosis and ballooning in the spinous zone of the epidermis Fully developed All the findings of early lesions plus: Ballooning vesiculation accompanied by marked reticular alteration Intraepidermal…

Histologic Diagnosis of Inflammatory Skin Diseases

Algorithms Predicated on “Nonspecific” Findings

In this section, algorithms used to reach specific diagnosis are predicated on “nonspecific” findings recognized best at higher magnification. Other changes requisite for specific diagnoses, i.e., denominators that are essential, then ar…

Histologic Diagnosis of Inflammatory Skin Diseases

Images

Images 10.99.1A: Vasculitis, small vessel, neutrophilic; panniculitis, lobular; perivascular and interstitial dermatitis, and vesicular dermatitis, subepidermal + 10.99.1B: Thrombi in the lumen of venules and countless bacteria in the int…

Histologic Diagnosis of Inflammatory Skin Diseases

Erythema multiforme

…Correlation clinicopathologic Macules result from spongiosis, ballooning, and a superficial perivascular infiltrate of lymphocytes. Intraepidermal blisters develop secondary to ballooning and spongiosis, and subepidermal ones consequent to severe va…

Differential Diagnosis in Dermatopathology

Photoallergic dermatitis vs. Phototoxic dermatitis

Papules, nodules, vesicles, and sometimes bullae that develop in response to “bites” of arthropods, among the most common offenders being mosquitoes, bedbugs, and mites of scabies….

Histologic Diagnosis of Inflammatory Skin Diseases

Prurigo pigmentosa

…ts of an urticarial papule with the addition of spongiosis and ballooning; a vesicle develops secondary to extensive ballooning, the color of it sometimes being gray because of necrosis en masse of epidermis; scale is a consequence of parakeratosis,…

Histologic Diagnosis of Inflammatory Skin Diseases

Burns

…lerity. Even in a burn early in development, some evidence of ballooning of epidermal keratocytes is discernible. If ballooning is extensive, intraepidermal vesiculation results. If the intraepidermal blister becomes sufficiently tense, it bursts, a…

Histologic Diagnosis of Inflammatory Skin Diseases

Pellagra

…, however, show pathognomonic changes in the form of extensive ballooning in a band across the upper half of the viable epidermis. Such ballooning is followed always by necrosis and, not uncommonly, by intraepidermal vesiculation that may progress to…