Histologic Diagnosis of Inflammatory Skin Diseases

Algorithms Predicated on “Nonspecific” Findings

…normal Lymphocytes in a Mixed-Cell Infiltrate of Inflammatory Cells Lymphocytes with large pleomorphic nuclei in the epidermis, dermis, or subcutaneous fat or at a combination of those sites; synonymous with “atypical lymphocytes.”…

Histologic Diagnosis of Inflammatory Skin Diseases

Identification of Basic Patterns: Skin: Vesicular Dermatitis

…logic surgical procedures (Fig. 5.305 A&B). The nuclei of cells of the viable epidermis, especially spinous ones, immediately become elongated strikingly, in the process coming to resemble string beans. Changes indistinguishable from those caused…

Histologic Diagnosis of Inflammatory Skin Diseases

Identification of Basic Patterns: Skin: Nodular and Diffuse Dermatitis

…e: Hand-Schüller-Christian disease. The large, pale-staining, bean-shaped nuclei and the abundant amphophilic cytoplasm of the cells that dominate this dense, diffuse infiltrate establish them as Langerhans” cells and the diagnosis as Hand-Schü…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Langerhans’ Cell Granulomatosis?

“The cells of histiocytosis X [HX] have been designated “histiocytes” but the “ordinary” histiocytes encountered in healthy skin, in histiocytoma or various granulomatous processes are devoid of the granules. It could…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Verruciform Xanthoma?

…ruciform appearance of the epithelium and the underlying foam cells. . . . One might suspect that epithelial breakdown, from some as yet unknown cause may secondarily elicit a foam-cell response. . . . The reverse may also be true. Perhaps foam cells

Histologic Diagnosis of Inflammatory Skin Diseases

Urticaria pigmentosa

…mastocytosis involves internal organs by infiltrates of mast cells. Mast cell leukemia, as the name denotes, is not related to urticaria pigmentosa. Differential diagnosis clinical Juvenile xanthogranuloma usually presents itself in a child as one…

Histologic Diagnosis of Inflammatory Skin Diseases

Errors and Reasons

…r: “Acute” and “chronic” inflammatory cells are characterizations accurately of neutrophils and eosinophils on one hand and of lymphocytes and histiocytes on the other. Reason: Because neutrophils and eosinophils may be presen…