Histologic Diagnosis of Inflammatory Skin Diseases

Identification of Basic Patterns: Skin: Perivascular Dermatitis

…e of congenital melanocytic nevus marked by angiocentricity of cells of the nevus (Fig. 5.36 A&B), the so-called nevus cells really being abnormal melanocytes. Figure 5.35 A&B. Simulation of an inflammatory disease. A perivascular lymphopl…

Histologic Diagnosis of Inflammatory Skin Diseases

Hair Follicles

…inge. Adamson’s fringe is the boundary between nucleated cells of a hair in the bulb of a follicle and anucleate cells of a hair in the stem of a follicle. Figure 1.23 A hair follicle can be divided, on the basis of considerations morphologi…

Histologic Diagnosis of Inflammatory Skin Diseases

Algorithms Predicated on “Nonspecific” Findings

In this section, algorithms used to reach specific diagnosis are predicated on “nonspecific” findings recognized best at higher magnification. Other changes requisite for specific diagnoses, i.e., denominators that are essential, then are added to a particular “nonspecific” finding, beginning with those attributes discernable at moderately high magnification and processing to those visualizable at progressively lower […]

Dermatology Practical & Conceptual

Langerhans cell histiocytosis-a case report

…junction (H&E, x100X). (F) A sheet of abnormal Langerhans cells (H&E, x400). (G) Cytological details of abnormal Langerhans cells. Note the coffee bean and kidney shapes of the large cleaved nucleus (H&E, x1000). [Copyright: ©2012 Jeunon…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Langerhans’ Cell Granulomatosis?

…HX) but this would imply that intraepidermal Langerhans’ cells [LC] or LC in the dermis represent pathologic, or at least, not “normal” cells, which is difficult to accept. If, on the other hand, the LC is considered a specific hist…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Verruciform Xanthoma?

…rruciform appearance of the epithelium and the underlying foam cells. . . . One might suspect that epithelial breakdown, from some as yet unknown cause may secondarily elicit a foam-cell response. . . . The reverse may also be true. Perhaps foam cell…

Histologic Diagnosis of Inflammatory Skin Diseases

Urticaria pigmentosa

…s are formed by dense diffuse monomorphous infiltrates of mast cells. Smaller versions of them, i.e., dome-shaped papules, are made up of fewer mast cells lodged superficially in the dermis. Bullae result from extensive subepidermal edema that lifts…