Histologic Diagnosis of Inflammatory Skin Diseases

Identification of Basic Patterns: Skin: Perivascular Dermatitis

…e of congenital melanocytic nevus marked by angiocentricity of cells of the nevus (Fig. 5.36 A&B), the so-called nevus cells really being abnormal melanocytes. Figure 5.35 A&B. Simulation of an inflammatory disease. A perivascular lymphopl…

Histologic Diagnosis of Inflammatory Skin Diseases

Hair Follicles

…inge. Adamson’s fringe is the boundary between nucleated cells of a hair in the bulb of a follicle and anucleate cells of a hair in the stem of a follicle. Figure 1.23 A hair follicle can be divided, on the basis of considerations morphologi…

Histologic Diagnosis of Inflammatory Skin Diseases

Algorithms Predicated on “Nonspecific” Findings

…cin also in septa of the subcutaneous fat, lymphocytes, plasma cells, and eosinophils in a perivascular and interstitial infiltrate, and those inflammatory cells in nodules at the junction of widened septa and fat lobules = Morphea     D…

Dermatology Practical & Conceptual

Langerhans cell histiocytosis-a case report

…junction (H&E, x100X). (F) A sheet of abnormal Langerhans cells (H&E, x400). (G) Cytological details of abnormal Langerhans cells. Note the coffee bean and kidney shapes of the large cleaved nucleus (H&E, x1000). [Copyright: ©2012 Jeunon…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Verruciform Xanthoma?

…rruciform appearance of the epithelium and the underlying foam cells. . . . One might suspect that epithelial breakdown, from some as yet unknown cause may secondarily elicit a foam-cell response. . . . The reverse may also be true. Perhaps foam cell…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Langerhans’ Cell Granulomatosis?

…HX) but this would imply that intraepidermal Langerhans’ cells [LC] or LC in the dermis represent pathologic, or at least, not “normal” cells, which is difficult to accept. If, on the other hand, the LC is considered a specific hist…

Histologic Diagnosis of Inflammatory Skin Diseases

Urticaria pigmentosa

…s are formed by dense diffuse monomorphous infiltrates of mast cells. Smaller versions of them, i.e., dome-shaped papules, are made up of fewer mast cells lodged superficially in the dermis. Bullae result from extensive subepidermal edema that lifts…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Dermal Papilla?

…220;Historically, the hair germ has been defined as a group of cells located at the base of the telogen follicle in close contact with the dermal papilla.” Lavker RM, Miller S, Wilson C, et al. Hair follicle stem cells: their location, role in…