Therapeutic Strategies in Dermatology

Oral Hairy Leukoplakia: Clinical Cases

Clinical Case Case 1 37-year-old male with recent diagnosis of HIV infection Not yet started on anti-retroviral medications Elevated viral load and reduced CD4 lymphocyte count (240) Presents for evaluation and management of long-standing “tongue…

Therapeutic Strategies in Dermatology

Aphthous Ulcers (Recurrent Aphthous Stomatitis, Canker Sore): Treatment

Treatment First-line therapy: Patients with active ulcers should avoid trauma to the oral mucosa (including hard toothbrushes or sharp foods) and limit intake of acidic products which can worsen pain. Topical analgesics and local protective topical…

Therapeutic Strategies in Dermatology

Angular Cheilitis: Clinical Cases

Clinical Cases Case 1 68-year-old healthy female No significant past medical history Edentulous with ill-fitting dentures Presents for evaluation and management of long-standing “lip ulcers” Initial evaluation Healthy appearing fem…

Histologic Diagnosis of Inflammatory Skin Diseases

Candidiasis

An inflammatory disease caused by the yeast Candida albicans and manifested clinically as erythematous papules and pustules that may become confluent to form plaques in the case of the former and erosions in the case of the latter. The nail unit may…

Histologic Diagnosis of Inflammatory Skin Diseases

Candidiasis

An inflammatory disease caused by the yeast Candida albicans and manifested clinically as erythematous papules and pustules that may become confluent to form plaques in the case of the former and erosions in the case of the latter. The nail unit may…

Histologic Diagnosis of Inflammatory Skin Diseases

Images

…ae in the cornified layer + 10.12.1C + 10.12.1D = Candidiasis One of many manifestations of candidiasis is intraepidermal pustules shown here. Acantholytic cells are a finding expected in intraepidermal pustules, both those in surface an…

Histologic Diagnosis of Inflammatory Skin Diseases

Algorithms Predicated on “Nonspecific” Findings

In this section, algorithms used to reach specific diagnosis are predicated on “nonspecific” findings recognized best at higher magnification. Other changes requisite for specific diagnoses, i.e., denominators that are essential, then ar…

Histologic Diagnosis of Inflammatory Skin Diseases

Hailey-Hailey disease

…stopathologic Hailey-Hailey disease misdiagnosed clinically as candidiasis: Denominators in common: Flaccid pustules and erosions that become confluent. Features differentiating: Hailey-Hailey disease differs clinically from candidiasis because of l…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Spongiform Pustular Diseases?

“The pustule I have designated spongiform (spongelike) was markedly and impressively seen in acrodermatitis continua of Hallopeau. It is composed of leukocytes that have migrated into the soaked epidermis, destroying epithelial cells by inva…