Histologic Diagnosis of Inflammatory Skin Diseases

Langerhans’ Cells

Langerhans’ cells, named for Paul Langerhans who, while a medical student in Berlin in 1868, was the first to describe them, are dendritic cells that reside just above the middle of the spinous zone of the epidermis. They make their appearance…

Histologic Diagnosis of Inflammatory Skin Diseases

Images

Images 10.13.1A: Vesicular dermatitis, subepidermal, neutrophils predominant + 10.13.1B: Numerous neutrophils in the dermis and in a subepidermal blister = Cicatricial pemphigoid The blister is situated on skin damaged badly by sunlight,…

Differential Diagnosis in Dermatopathology

Differential Diagnosis

…is without a wedge episodic and not in repeatable pattern 3. Cleft between atrophic epidermis and dermis common 3. Cleft between atrophic epidermis and dermis uncommon 4. No thickened epidermal basement membrane 4. Thickened epidermal (surface an…

Histologic Diagnosis of Inflammatory Skin Diseases

Identification of Basic Patterns: Skin: Perivascular Dermatitis

See Figs. 5.16 A&B, 5.17 A&B, 5.18 A&B, 5.19 A&B, 5.20 A&B, 5.21 A&B, and 5.22 A&B Figure 5.16 A. Perivascular dermatitis, perivascular only, superficial. B. Perivascular dermatitis, perivascular only, superficial and…

Differential Diagnosis in Dermatopathology

Atrophic lichen planus vs. Atrophic discoid lupus erythematosus

A genetically determined disorder in which numerous closely set keratotic papules are present on the skin, especially the trunk, in nail units, and on mucous membranes, particularly the palate, but also rarely in other parts of the gastrointestinal…

Histologic Diagnosis of Inflammatory Skin Diseases

Lichen planus

…traordinarily accelerated process that culminates in vesicles. Clefts cannot be seen clinically; blisters can be. Histopathologically, clefts in lichen planus seem to represent a caricature of vacuoles that have become confluent; they contain neither…

Histologic Diagnosis of Inflammatory Skin Diseases

Grover’s disease

…tholytic dyskeratotic cells may be found just above suprabasal clefts in an epidermis that otherwise is mostly cohesive, they may be unassociated with parakeratosis (pemphigus vulgaris type), they may be present above suprabasal clefts in an epidermi…