Histologic Diagnosis of Inflammatory Skin Diseases

Images

Images 10.13.1A: Vesicular dermatitis, subepidermal, neutrophils predominant + 10.13.1B: Numerous neutrophils in the dermis and in a subepidermal blister = Cicatricial pemphigoid The blister is situated on skin damaged badly by sunlight,…

Histologic Diagnosis of Inflammatory Skin Diseases

Hair Follicles

Morphologic and qualitative differences in hair, a cornified end-product of matrical cells positioned in the center of a follicular bulb, exist among the races of Man. In general, Caucasians have the most prominent hair, Asians have the least, and A…

Differential Diagnosis in Dermatopathology

Atrophic lichen planus vs. Atrophic discoid lupus erythematosus

A genetically determined disorder in which numerous closely set keratotic papules are present on the skin, especially the trunk, in nail units, and on mucous membranes, particularly the palate, but also rarely in other parts of the gastrointestinal…

Histologic Diagnosis of Inflammatory Skin Diseases

Lichen planus

…traordinarily accelerated process that culminates in vesicles. Clefts cannot be seen clinically; blisters can be. Histopathologically, clefts in lichen planus seem to represent a caricature of vacuoles that have become confluent; they contain neither…

Histologic Diagnosis of Inflammatory Skin Diseases

Grover’s disease

…tholytic dyskeratotic cells may be found just above suprabasal clefts in an epidermis that otherwise is mostly cohesive, they may be unassociated with parakeratosis (pemphigus vulgaris type), they may be present above suprabasal clefts in an epidermi…

Differential Diagnosis in Dermatopathology

Differential Diagnosis

…is without a wedge episodic and not in repeatable pattern 3. Cleft between atrophic epidermis and dermis common 3. Cleft between atrophic epidermis and dermis uncommon 4. No thickened epidermal basement membrane 4. Thickened epidermal (surface an…

Histologic Diagnosis of Inflammatory Skin Diseases

Fixed drug eruption

Fixed drug eruption Synonyms Fixed toxic exanthem Presentation stereotypical Age and sex Adults of both sexes Distribution of lesions Lips, genital region, and limbs especially Configuration of lesions Round Arrangement of lesions Solitary or few, d…