Search Results for: collagen

Histologic Diagnosis of Inflammatory Skin Diseases

Necrobiosis lipoidica

…efined in a repeatable, let alone comprehensible, way. Some authors equate “necrobiosis” with “necrosis of collagen,” but collagen is a fiber, not a cell, and, therefore, cannot undergo necrosis. We eschew the term…

Histologic Diagnosis of Inflammatory Skin Diseases

Suggested Readings

…1997;38(4):394-406. Postlethwaite AE, Seyer JM, Kang AH. Chemotactic attraction of human fibroblasts to type I, II, and III collagens and collagen related peptides. Proc Natl Acad Sci U S A 1978;75:871-875. Schepers C, Ackerman AB. Dermal…

Histologic Diagnosis of Inflammatory Skin Diseases

Images

…us with evidences of excoriation The findings in this section reflect effects of both persistent rubbing (hyperkeratosis and collagen bundles in vertical streaks) and lively scratching (erosion and ulceration). 10.23.9A: Ulcer and crust, well…

Histologic Diagnosis of Inflammatory Skin Diseases

Images

…iosis there make this mycosis fungoides. 11.14.40A: Perivascular dermatosis, patchy lichenoid + 11.14.40B: Coarse bundles of collagen in haphazard array in the upper part of the dermis in association with negligible spongiosis = Mycosis fungoides,…

Histologic Diagnosis of Inflammatory Skin Diseases

Lichen sclerosus et atrophicus

…y developed—lateCollagen bundles in the dermis are organized in two different patterns, namely, sclerosis, i.e., outlines of collagen bundles no longer are discernible, in the upper part, and markedly thickened bundles of collagen whose outlines are…

Histologic Diagnosis of Inflammatory Skin Diseases

Cells That Mediate Inflammation (Inflammatory Cells)

…nuclear chromatin becomes more condensed. Fibrocytes help to remodel collagen by synthesizing and secreting enzymes, such as collagenase, that degrade collagen and other components of the extracellular matrix. The term fibrocyte is used by us as…

Differential Diagnosis in Dermatopathology

Discussions

…brightly eosinophilic, markedly thickened collagen bundles arranged haphazardly appear in the mass of fibrillary bundles of collagen. Those thickened bundles of collagen, in that particular setting, are signs of a keloid. The diagnosis…

Histologic Diagnosis of Inflammatory Skin Diseases

Keloid

…aracteristic, however, are encountered at times in scarring processes other than real keloids. For example, thick bundles of collagen in haphazard array, i.e., keloidal collagen, are found in the upper part of some dermatofibromas, in certain…

Nodular melanoma: five consecutive cases in a general practice with polarized and non-polarized dermatoscopy and dermatopathology

Nodular melanoma: five consecutive cases in a general practice with polarized and non-polarized dermatoscopy and dermatopathology

…toscopic polarizing-specific white lines (B), and consistent with the hypothesis that these structures correlate to vertical collagen bands, none of these are seen in the dermatopathologic images although abundant collagen surrounds nests of…