Histologic Diagnosis of Inflammatory Skin Diseases

Necrobiosis lipoidica

…of histiocytes of granuloma annulare are found degeneration of collagen, a tad of fibrin, and abundant mucin; in that of necrobiosis lipoidica, abundant degenerated collagen in early lesions and crowded thickened bundles of collagen in later ones; in…

Histologic Diagnosis of Inflammatory Skin Diseases

Suggested Readings

…otactic attraction of human fibroblasts to type I, II, and III collagens and collagen related peptides. Proc Natl Acad Sci U S A 1978;75:871-875. Schepers C, Ackerman AB. Dermal dendrocyte? Dermatopathol Pract Concept, 1997. Smith LT, Holbrook KA. Em…

Histologic Diagnosis of Inflammatory Skin Diseases

Images

…reflect effects of both persistent rubbing (hyperkeratosis and collagen bundles in vertical streaks) and lively scratching (erosion and ulceration). 10.23.9A: Ulcer and crust, well circumscribed + 10.23.9B: Degeneration of bundles of collag…

Histologic Diagnosis of Inflammatory Skin Diseases

Images

…ermatosis, patchy lichenoid + 11.14.40B: Coarse bundles of collagen in haphazard array in the upper part of the dermis in association with negligible spongiosis = Mycosis fungoides, patch/plaque ¬†Coarse bundles of collagen in random array are a c…

Histologic Diagnosis of Inflammatory Skin Diseases

Lichen sclerosus et atrophicus

…sent throughout a thickened papillary dermis, i.e., bundles of collagen appear to be “homogenized” and fibrocytes are decreased in number, and bundles of collagen in the uppermost part of the reticular dermis are thickened and crowded. In…

Histologic Diagnosis of Inflammatory Skin Diseases

Cells That Mediate Inflammation (Inflammatory Cells)

…e, which is reflected histopathologically in the appearance of collagen, that protein being altered and assuming a basophilic hue. Granules of eosinophils, once degranulated and having enveloped degenerated, blue-staining collagen bundles in discrete…

Differential Diagnosis in Dermatopathology

Discussions

…development, i.e., prior to the appearance of thick bundles of collagen. When distinct, brightly eosinophilic, thick bundles of collagen are arrayed haphazardly in a lesion made up entirely of fibroplasia, the diagnosis, by convention, is keloid. No…

Histologic Diagnosis of Inflammatory Skin Diseases

Keloid

…., an increased number of fibrocytes and fibrillary bundles of collagen seemingly in haphazard array Fully developed Numerous thick, brightly eosinophilic bundles of collagen arranged in vaguely labyrinthine fashion Plump fibrocytes paralleling the…

Histologic Diagnosis of Inflammatory Skin Diseases

Mycosis fungoides

Mycosis fungoides Synonyms Cutaneous T-cell lymphoma Presentation stereotypical Age and Sex Adults usually, although children may be affected. Males preponderant. Distribution of lesions Often widespread, but sometimes localized to a single patch or…