Histologic Diagnosis of Inflammatory Skin Diseases

Identification of Basic Patterns: Skin: Vesicular Dermatitis

See Fig. 5.239 A-C. Figure 5.239 A-C. Patterns of vesiculation: intraepidermal, subepidermal, and intra- and subepidermal. “Blister” and “vesiculobullous” are terms generic for lesions of the skin that usually are elevated…

Histologic Diagnosis of Inflammatory Skin Diseases

Images

Images 10.2.1A: Perivascular dermatitis, spongiotic and slightly psoriasiform + 10.2.1B: Slight edema of the papillary dermis and scale-crust = Nummular dermatitis  Changes such as these are indistinguishable from those of allergic contac…

Dermatology Practical & Conceptual

Saved by step sections: an unusual presentation of basal cell carcinoma

…ure 1. Clinical appearance: 2 cm erythematous patch with focal crusting and scaling. [Copyright: ©2011 Werner et al.] Figure 2A. Panoramic view of first section showing well demarcated area of ulceration of the epidermis with crust. Original magni…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Reactive Perforating Collagenosis?

“A case is presented exhibiting an unusual reaction of the skin to superficial trauma. In response to minor trauma, certain changes take place within the papillary layer of the corium characterized by affinity of the connective tissue for he…

Histologic Diagnosis of Inflammatory Skin Diseases

Images

Images 10.22.1A: Vesicular dermatitis, intraepidermal, spongiotic + 10.22.1B: Hyphae in the cornified layer = Dermatophytosis Were there no hyphae present in the stratum corneum, the differential diagnosis also would include allergic cont…

Histologic Diagnosis of Inflammatory Skin Diseases

Images

Images 10.25.1A: Perivascular dermatitis, interface, vacuolar + 10.25.1B: Lymphocytes around venules and along the dermoepidermal junction, many necrotic keratocytes, thin epidermis, hypergranulosis, and orthokeratosis = Drug eruption The…

Histologic Diagnosis of Inflammatory Skin Diseases

Images

Images 10.90.1A: Perivascular dermatitis, psoriasiform + 10.90.1B: Lymphocytes and neutrophils around venules, dilated tortuous capillaries in edematous dermal papillae, spongioform pustules, and tiers of neutrophil-containing mounds of p…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Primary and Secondary Lesions?

“Some of the appearances observed in cutaneous diseases are caused directly by the deposition of morbid products in the skin. These bear the name of Primary symptoms or eruptions, Efflorescentiae cutaneae primariae. But these eruptions often…

Histologic Diagnosis of Inflammatory Skin Diseases

Images

Images 10.5.1A: Perivascular and interstitial dermatitis + 10.5.1B: Lymphocytes and eosinophils around venules, and neutrophils in the interstitium in conjunction with degeneration of bundles of collagen focally = Response to an arthropod…