Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Scleroderma?

…to pancreatitis or pancreatic carcinoma. Lesions of childhood dermatomyositis unassociated with malignant neoplasia and those of adult dermatomyositis secondary to the effects of a internal malignancy may be indistinguishable morphologically, i.e.,…

Histologic Diagnosis of Inflammatory Skin Diseases

Applicable Terms

ABSCESS [L. abscessus (a going away)]: Clinically, a circumscribed collection of pus and histopathologically a localized collection of neutrophils. An abscess may form in the epidermis, both surface and infundibular, eccrine ducts, dermis, and subcu…

Histologic Diagnosis of Inflammatory Skin Diseases

Ground Substance

Ground substance (extrafibrillar matrix) is finely granular extracellular material that enmeshes fibrillar and cellular components of the body, including those of the dermis, binds water, and provides hydration to the skin. The ground substance of n…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Colors Stereotypical for Diseases Specific?

“The color of skin lesions varies as already stated. … White lesions are rare excepting in exfoliative diseases, the scales of which are white. They usually result from loss of pigment. White spot disease, morphea, some of the idiopathi…

Histologic Diagnosis of Inflammatory Skin Diseases

Scar

Scar Synonyms Cicatrix Presentation stereotypical Age and sex Any age and both sexes Distribution of lesions Usually localized, but sometimes widespread Configuration of lesions Linear, as in a surgical wound Round, as a consequence of an ulcer ind…

Histologic Diagnosis of Inflammatory Skin Diseases

Identification of Basic Patterns: Skin: Vasculitis

See Fig. 5.218 A&B. Figure 5.218 Vasculitis. A. Small vessel. B. Large vessel. Before a reasoned and reasonable method for diagnosis histopathologic of vasculitis in skin and subcutaneous fat can be formulated, a definition of vasculitis must…

Histologic Diagnosis of Inflammatory Skin Diseases

Images

Images 10.42.1A: Perivascular dermatitis, interface, vacuolar + 10.42.1B: Lymphocytes along the dermoepidermal junction, slight spongiosis, and necrotic keratocytes in a thin epidermis = Graft-versus-host disease Sometimes it is difficult…

Histologic Diagnosis of Inflammatory Skin Diseases

Porphyria cutanea tarda

Porphyria cutanea tarda Presentation stereotypical Age and sex Young and middle-aged adults of both sexes, but mainly women taking estrogens or who are alcoholic Distribution of lesions Blisters on dorsa of hands and feet, pigmentary alterations and…

Differential Diagnosis in Dermatopathology

Discussions

Histopathologically, lesions developed fully of discoid lupus erythematosus and polymorphous light eruption have in common the presence of moderately dense infiltrates made up overwhelmingly of lymphocytes around venules of both vascular plexuses. C…