Histologic Diagnosis of Inflammatory Skin Diseases

Polymorphous light eruption

…scular infiltrate of lymphocytes Marked edema of the papillary dermis Subepidermal vesiculation secondary to edema of the papillary dermis occurs uncommonly; epidermis usually tethered to the dermis by gossamer strands of collagen Spongiosis of varia…

Histologic Diagnosis of Inflammatory Skin Diseases

Blood Vessels

…les and venules is situated in the lower part of the reticular dermis, and the superficial plexus is positioned in the upper part of the reticular dermis, just beneath the papillary dermis. In times past, the superficial plexus was called the “…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Radial Growth Phase versus Vertical Growth Phase of Melanoma?

…to the vertical-growth phase acquire the ability to invade the dermis and form an expansile nodule, widening the papillary dermis.” “Radial-Growth Phase: Decreased differentiation, unlimited hyperplasia, cannot grow in soft agar, clonal p…

Histologic Diagnosis of Inflammatory Skin Diseases

Images

…and for a long period of time, everything above the reticular dermis may thicken, as shown here. The papillary dermis is thickened by altered bundles of collagen, the spinous layer of the epidermis, both surface and infundibular, is thickened, and s…

Histologic Diagnosis of Inflammatory Skin Diseases

Identification of Basic Patterns: Skin: Nodular and Diffuse Dermatitis

…are centered around venules, usually throughout the reticular dermis (Fig. 5.175 A&B), but sometimes also in septa of the subcutaneous fat and at other times restricted to the upper part of the dermis (Fig. 5.176 A&B). Very often, endothelia…

Histologic Diagnosis of Inflammatory Skin Diseases

Identification of Basic Patterns: Skin: Vesicular Dermatitis

…blister: The roof in the latter is “blown off” the dermis. This soon-to-be blister of polymorphous light eruption resulted from the epidermis being lifted from its moorings by edema in extraordinary amount in the papillary dermis. As long…

Histologic Diagnosis of Inflammatory Skin Diseases

Arthropod assaults

…and eosinophils scattered in the interstitium of the reticular dermis; a few neutrophils may be discernible Slight edema of the papillary dermis A discrete focus of spongiosis present sometimes in the epidermis at the very site of the “bite,&#8…

Histologic Diagnosis of Inflammatory Skin Diseases

Errors and Reasons

…: Lichen sclerosus et atrophicus is a disease of the papillary dermis. Reason: Although “lichen sclerosus et atrophicus” involves principally the papillary dermis, which is thickened by sclerosis of it, associated with it always are chang…

Histologic Diagnosis of Inflammatory Skin Diseases

Pigmented Lesions

…9) Melanophages in number variable scattered in the papillary dermis, rarely in the upper part of the reticular dermis too. Melanin increased in amount in the epidermis. Dermatofibroma¬†(183, 520) Proliferation of fibrocytes and histiocytes (lipo…