Histologic Diagnosis of Inflammatory Skin Diseases

Leprosy

…of numerous papules, nodules, cords, or tumors, or it may be diffuse, i.e., lepra bonita. Dimorphous leprosy, as the name denotes, is intermediate between tuberculoid and lepromatous leprosy in regard to immunity of the host; it presents itself as m…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Eosinophilic Cellulitis (Wells’ Syndrome)?

…fied a lesion as being eosinophilic cellulitis were edema and diffuse infiltration of the dermis with eosinophils and histiocytes in conjunction with flame figures. Apart from blood eosinophilia, the patients had no notable systemic signs or symptoms…

Histologic Diagnosis of Inflammatory Skin Diseases

Erythema nodosum leprosum

…ly Suppurative lobular panniculitis, focal at first and then diffuse Patchy zones of extensive fat necrosis Foam cells scattered in fat lobules In fibrous septa of the subcutaneous fat, fibrin in the wall of some small vessels and thrombi in the lum…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Scleroderma?

…the skin characterized by the appearance of circumscribed or diffuse, hard, smooth, ivory-colored areas that are immobile and give the appearance of hide-bound skin. Scleroderma occurs in both systemic and localized forms. . . . Systemic and localiz…

Histologic Diagnosis of Inflammatory Skin Diseases

Images

…typical of spores of Histoplasma capsulatum. 10.17.4A: Diffuse infiltration by cells + 10.17.4B: Yeasts, each of which is surrounded by a prominent halo formed of a gelatinous capsule = Cryptococcosis The absence of an infiltrate of inflam…

Histologic Diagnosis of Inflammatory Skin Diseases

Urticaria pigmentosa

…ases; Darier’s sign can be induced by vigorous rubbing. Diffuse mastocytosis is manifested as thickened, leathery, yellowish skin, whose folds are exaggerated. Systemic mastocytosis involves internal organs by infiltrates of mast cells. Mast ce…

Histologic Diagnosis of Inflammatory Skin Diseases

Study By Disease

…stular (Quiz #178) Desmoplastic trichoepithelioma (Quiz #296) Diffuse large B-cell lymphoma (Quiz #387) Diffuse large B-cell lymphoma (Quiz #388) Diffuse large B-cell lymphoma (Quiz #611) Diffuse large B-cell lymphoma (Quiz #613) Disseminated superfi…

Dermatology Practical & Conceptual

When all you have is a dermatoscope—start looking at the nails

…y less frequently cause non-continuous nail alterations. Many systemic diseases that may also show involvement of the nails (e.g., psoriasis, atopic dermatitis, lichen planus, alopecia areata) tend to induce alterations in numerous if not all nails o…

Histologic Diagnosis of Inflammatory Skin Diseases

Images

Images 10.114.1A: Diffuse dermatitis, granulomatous + 10.114.1B: Foamy histiocytes, many of them multinucleate = Xanthogranuloma, fully developed  Lymphocytes, plasma cells, and eosinophils are scattered among the predominant histiocytes,…