Histologic Diagnosis of Inflammatory Skin Diseases

Xanthogranuloma

…lasma cells around venules Late Fibroplasia amidst the dense diffuse infiltrate of foam cells Patchy mixed-cell infiltrate of lymphocytes, plasma cells, and eosinophils Correlation clinicopathologic Papules and nodules are expressions of dense dif…

Histologic Diagnosis of Inflammatory Skin Diseases

Leprosy

Leprosy Synonyms Hansen’s disease Lepra Presentation stereotypical Age and sex Young adults of both sexes who live in endemic areas Distribution of lesions Localized in indeterminate and tuberculoid types; widespread and symmetrical in lepro…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Eosinophilic Cellulitis (Wells’ Syndrome)?

…ified a lesion as being eosinophilic cellulitis were edema and diffuse infiltration of the dermis with eosinophils and histiocytes in conjunction with flame figures. Apart from blood eosinophilia, the patients had no notable systemic signs or symptom…

Histologic Diagnosis of Inflammatory Skin Diseases

Erythema nodosum leprosum

…e, clinically, of painful and tender nodules in a patient with diffuse or nodular lepromatous leprosy, whereas a diagnosis of Lucio’s phenomenon is established clinically on the basis of hemorrhagic infarcts in a patient with diffuse lepromatou…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Scleroderma?

…(en coup de sabre and facial hemiatrophy) Both cutaneous and systemic Progressive systemic sclerosis Diffuse systemic sclerosis CREST syndrome Chemically induced, e.g., l-tryptophan-related eosinophilia-myalgia syndrome, toxic oil syndrome, exposu…

Histologic Diagnosis of Inflammatory Skin Diseases

Urticaria pigmentosa

…tases; Darier’s sign can be induced by vigorous rubbing. Diffuse mastocytosis is manifested as thickened, leathery, yellowish skin, whose folds are exaggerated. Systemic mastocytosis involves internal organs by infiltrates of mast cells. Mast c…

Histologic Diagnosis of Inflammatory Skin Diseases

Images

Images 10.17.1A: Nodular dermatitis, granulomatous + 10.17.1B: Collections of histiocytes enveloped by lymphocytes and plasma cells, and brown spores in a multinucleate macrophage = Chromomycosis In a fully developed lesion of chromomyco…

Dermatology Practical & Conceptual

When all you have is a dermatoscope—start looking at the nails

…) Overview. (B) Dermatoscopy. The dermatoscopic view reveals a diffuse yellow-red discoloration of multiple nails indicative of an increased vascularization of the nail matrix and a diffuse transient extravasation of erythrocytes. Multiple dot-shaped…

Dermatology Practical & Conceptual

Nodules on the right ear

Case report A healthy 17-year-old boy with a one-year history of asymptomatic, slowly enlarging nodules affecting his right ear was seen. The patient’s past medical history was unremarkable, he was not immunosuppressed, he was not taking any d…