Histologic Diagnosis of Inflammatory Skin Diseases

Algorithms Predicated on “Nonspecific” Findings

…e of the skin. Click image to enlarge. + Foci of acantholytic dyskeratosis near one another and about equidistant from one another, often in the absence of inflammatory cells = Darier”s disease, a type of systematized epidermal nevus, acantholy…

Dermatology Practical & Conceptual

Dermoscopic findings in bowenoid papulosis: report of two cases

…e histology showed mild hyperkeratosis, irregular acanthosis, dyskeratosis, cytological atypia and mitosis (Figures 4 and 5), consistent with the diagnosis of BP. Figure 1. Small gray-brown papules. (Copyright: ©2014 Marcucci et al.) Figures…

Differential Diagnosis in Dermatopathology

Discussions

…ermal rete ridges, analogous to isolated loci of acantholytic dyskeratosis, epidermolytic hyperkeratosis, cornoid lamellation, and pale-cell acanthosis, distinctive patterns of cutaneous epithelium all. In the years following the original description…

Dermatology Practical & Conceptual

Epidermal multinucleated giant cells are not always a histopathologic clue to a herpes virus infection: multinucleated epithelial giant cells in the epidermis of lesional skin biopsies from patients with acantholytic dermatoses can histologically mimic a herpes virus infection

…biopsy specimen showed acanthosis with focal acantholysis and dyskeratosis; viral cytopathic changes were absent. Lymphocytic inflammation was present in the upper dermis (Figure 7). Correlation of the clinical presentation, laboratory studies, and p…

Differential Diagnosis in Dermatopathology

Epidermolytic hyperkeratosis vs. Plane wart

A keratotic condition of the palms and soles, inherited usually, but sometimes acquired, in which involvement may be diffuse, circumscribed (including striate), or punctate….

Histologic Diagnosis of Inflammatory Skin Diseases

Identification of Basic Patterns: Skin: Perivascular Dermatitis

…, an inflammatory process characterized by focal acantholytic dyskeratosis, is pruritic in general but especially when eosinophils are numerous, as is the case here. The focus of epidermal necrosis, evident by keratocytes being eosinophilic, is a sur…

Differential Diagnosis in Dermatopathology

Differential Diagnosis

…over’s disease) sometimes 5. Findings of acantholytic dyskeratosis in foci are the sole manifestation 5. Findings in foci sometimes of pemphigus (superficial and deep types), familial benign chronic pemphigus (Hailey-Hailey disease), spongios…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Apoptosis?

…h ed. Philadelphia: W. B. Saunders Company, 1999:18. “Dyskeratosis, or apoptosis, refers to eosinophilic hyalinized changes within individual keratinocytes, associated with pyknosis, and ultimate loss of the nucleus. Apoptosis is referred to…