Differential Diagnosis in Dermatopathology

Discussions

…changes that are more focal, parakeratosis more prominent, and dyskeratosis more extensive in the granular zone and cornified layer. Hailey-Hailey like Darier’s disease and unlike pemphigus vulgaris, is marked by both acantholysis and dyskerato…

Histologic Diagnosis of Inflammatory Skin Diseases

Images

Images 10.86.1A: Perivascular dermatitis, lymphocytic + 10.86.1B: Thin cornoid lamella = Porokeratosis, disseminated superficial actinic ┬áThe cornoid lamella on the left springs from an infundibulum. Cornoid lamellae also may emanate from…

Histologic Diagnosis of Inflammatory Skin Diseases

Identification of Basic Patterns: Skin: Perivascular Dermatitis

See Figs. 5.16 A&B, 5.17 A&B, 5.18 A&B, 5.19 A&B, 5.20 A&B, 5.21 A&B, and 5.22 A&B Figure 5.16 A. Perivascular dermatitis, perivascular only, superficial. B. Perivascular dermatitis, perivascular only, superficial and…

Differential Diagnosis in Dermatopathology

Epidermolytic hyperkeratosis vs. Plane wart

Epidermal nevi are hamartomas in which the epidermis is abnormal, being hyperkeratotic, and in which lesions are aligned along Blaschko’s lines….

Histologic Diagnosis of Inflammatory Skin Diseases

Errors and Reasons

Error: Abortive is an accurate modifier of particular pathologic processes, e.g., abortive dermatofibroma, abortive morphea, and abortive T-cell lymphoma. Reason: The idea itself is abortive! For example, what is called “abortive T-cell lympho…

Differential Diagnosis in Dermatopathology

Differential Diagnosis

Darier’s disease (keratosis follicularis) Grover’s disease (transient acantholytic dermatosis) 1. No evidence of excoriation usually 1. Erosions, ulcerations, and scale-crusts, i.e., evidences of excoriation, present often 2. Focal…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Apoptosis?

“… this distinctive type of necrosis (apoptosis)…has previously been called shrinkage necrosis on morphological grounds.” Kerr JFR. Wyllie AH, Currie AR. Apoptosis: a basic biological phenomenon with wide ranging implicatio…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Sclerotic Fibroma?

“Nine biopsies revealed a distinctive type of fibroma characterized by an organized pattern of interwoven fascicles of collagen bundles with a laminated or tortuous appearance, embedded in abundant mucin. A number of fibromas showed striking…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Eosinophilic Cellulitis (Wells’ Syndrome)?

“This is a study of the clinical features of four patients in the light of particular cutaneous histopathology. The characteristic eruption is periodic, tending to recur every few months, usually without systemic symptoms. The acute state of…