Differential Diagnosis in Dermatopathology

Discussions

Both angiolymphoid hyperplasia with eosinophilia and angiosarcoma are processes pathologic that involve endothelium-lined blood vessels. Whereas angiolymphoid hyperplasia with eosinophilia is a vascular malformation that comes into being by virtue o…

Histologic Diagnosis of Inflammatory Skin Diseases

Algorithms Predicated on “Nonspecific” Findings

In this section, algorithms used to reach specific diagnosis are predicated on “nonspecific” findings recognized best at higher magnification. Other changes requisite for specific diagnoses, i.e., denominators that are essential, then ar…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Wegener’s Granulomatosis?

“Inside the nose besides extensive necrosis, there is a cell-rich granulomatous tissue with granulomatous epithelioid cell foci which surround the vessels. . . . In both lungs: infarct-like necrosis in which one finds severe changes in the ve…

Histologic Diagnosis of Inflammatory Skin Diseases

Errors and Reasons

Error: Abortive is an accurate modifier of particular pathologic processes, e.g., abortive dermatofibroma, abortive morphea, and abortive T-cell lymphoma. Reason: The idea itself is abortive! For example, what is called “abortive T-cell lympho…

Histologic Diagnosis of Inflammatory Skin Diseases

Images

Images 10.55.1A: Nodular dermatitis, mixed-cell + 10.55.1B: Lymphoid follicles and many eosinophils in the dermis, both between nodules and in them + 10.55.1C + 10.55.1D = Kimura’s disease ¬†Only rarely are vascular chan…

Histologic Diagnosis of Inflammatory Skin Diseases

Identification of Basic Patterns: Subcutaneous Fat: Panniculitis

See Fig. 5.385 A-C. Figure 5.385 Patterns of panniculitis. A. Septal mostly. B. Lobular mostly. C. Septal and lobular “equally.” At scanning magnification, the normal subcutaneous fat is seen to be segregated by struts of fibrous tiss…

Differential Diagnosis in Dermatopathology

Lichen sclerosus et atrophicus vs. Superficial morphea

A disease manifested chiefly in the skin by vesicles and bullae that appear on sites of trauma, especially the face and dorsa of the hands, often in conjunction with macular hyperpigmentation and hypertrichosis of a face and sclerodermoid changes on…

Differential Diagnosis in Dermatopathology

Discussions

At first glance, a reader might think an error previous has been made because the two columns preceding are identical, but that was done deliberately; lichen sclerosis et atrophicus is superficial morphea. Morphea is one of the sclerodermas and lich…