Histologic Diagnosis of Inflammatory Skin Diseases

Urticaria

…iltrate of few lymphocytes in conjunction with neutrophils and eosinophils around venules and neutrophils and eosinophils scattered interstitially Late Sparse perivascular infiltrate of lymphocytes, and only a few, if any, eosinophils; no neutrophi…

Histologic Diagnosis of Inflammatory Skin Diseases

Images

…nd interstitial infiltrate of many neutrophils and innumerable eosinophils in infundibula and sebaceous lobules = Eosinophilic pustular folliculitis Because eosinophils are more conspicuous than neutrophils in this condition, it has been termed ̶…

Histologic Diagnosis of Inflammatory Skin Diseases

Identification of Basic Patterns: Skin: Nodular and Diffuse Dermatitis

See Fig. 5.174 A&B. Figure 5.174 A&B. Nodular dermatitis and diffuse dermatitis. Nodular dermatitis is distinguished from perivascular dermatitis (see Fig. 5.16 A&B) by the density of the infiltrate of inflammatory cells. In the periv…

Histologic Diagnosis of Inflammatory Skin Diseases

Images

…etiformis. 10.19.7A: Vesicular dermatitis, subepidermal, eosinophils prominent + 10.19.7B: Eosinophils, neutrophils, and nuclear “dust” in a subepidermal space = Dermatitis herpetiformis The subtle changes present in this sectio…

Histologic Diagnosis of Inflammatory Skin Diseases

Images

…stitial dermatitis, mixed-cell + 10.89.1B: Lymphocytes and eosinophils around venules and a few eosinophils in the interstitium = Pruritic urticarial papules and plaques of pregnancy ¬†The findings pictured can be distinguished from those of a res…

Histologic Diagnosis of Inflammatory Skin Diseases

Applicable Terms

…l mixed-cell infiltrate in which lymphocytes, neutrophils, and eosinophils ring venules and neutrophils and eosinophils are scattered in the interstitium. Contrariwise, so-called urticarial vasculitis exhibits stereotypical changes of leukocytoclasti…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Angiolymphoid Hyperplasia with Eosinophilia/Kimura’s Disease?

“The proliferation of connective tissue and fibrosis was marked in the lesions, and was associated with various small round cell infiltrates and eosinophils. . . . Within the lesions, lymphoid follicles were prominent.” Kimura T, Yoshi…

Histologic Diagnosis of Inflammatory Skin Diseases

Images

Images 11.13.1A: Perivascular and interstitial dermatosis, infundibulocentric + 11.13.1B: Small lymphocytes, large abnormal lymphocytes, neutrophils and eosinophils = Lymphomatoid papulosis ¬†Episodically, as shown here, an infiltrate of l…

Histologic Diagnosis of Inflammatory Skin Diseases

Images

…ascular dermatitis, interface, lichenoid + 10.25.2B: A few eosinophils in an infiltrate of lymphocytes mostly = Drug eruption The presence of eosinophils in a lesion that otherwise is indistinguishable histopathologically from that of Mucha-Haber…

Histologic Diagnosis of Inflammatory Skin Diseases

Images

…iasiform lichenoid + 10.77.6B: Lymphocytes and innumerable eosinophils in the dermal infiltrate, marked edema of the papillary dermis, and eosinophils in an epidermis associated with suprabasal clefts and acantholytic cells in foci = Pemphigus vu…