Search Results for: epidermis

Histologic Diagnosis of Inflammatory Skin Diseases

Syphilis

…cks plasma cells, and usually is devoid of involvement of the epidermis. Clues to specific diagnosis histopathologic Striking pallor of cells in the upper part of the spinous zone and the granular layer is a clue to deficiency diseases such as pellag…

Histologic Diagnosis of Inflammatory Skin Diseases

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…phils in the edematous papillary dermis and in the acanthotic epidermis = Bullous pemphigoid, urticarial Eosinophils in the epidermis induce spongiosis that, at times, leads to formation of spongiotic vesicles. Uncommonly, a blister in bullous pemphi…

Histologic Diagnosis of Inflammatory Skin Diseases

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…221; An exceptional finding in the absence of necrosis of the epidermis is numerous neutrophils in an intraepidermal vesicle induced by the “bite” of an insect. Necrosis, in general, is chemotactic for neutrophils. 10.5.4A: Vesicular derm…

Histologic Diagnosis of Inflammatory Skin Diseases

Errors and Reasons

…o-called apocrine miliaria, spongiosis occurs in infundibular epidermis, whereas in miliaria rubra it appears in surface epidermis; Fox-Fordyce disease presents itself, clinically and histopathologically, as a plug of horn (cornified cells) in infund…

Histologic Diagnosis of Inflammatory Skin Diseases

Lupus erythematosus

…in the dermis, along the dermaepidermal junction, and in the epidermis. Bullous lupus erythematosus, which consists of vesicles as well as bullae, can be thought of as acceleration inordinately of the changes in a “butterfly blush,” anal…

Histologic Diagnosis of Inflammatory Skin Diseases

Hair Follicles

…ntinuous with an infundibulum, the funnel-shaped component of epidermis that reaches from the ostium at the surface of the skin above to the uppermost part of the follicle, i.e., the isthmus, below. In a longitudinal section, a mature follicle may be…

Histologic Diagnosis of Inflammatory Skin Diseases

Images

…and individual necrotic keratocytes in the upper part of the epidermis = Phototoxic dermatitis In the realm of photodermatitis, the presence of many individual necrotic keratocytes, revealed here by pyknotic nuclei and eosinophilic cytoplasm, indica…

Histologic Diagnosis of Inflammatory Skin Diseases

Images

…hickened bundles of collagen. Above the dermal component, the epidermis is acanthotic and hyperkeratotic. Marked compact orthokeratosis signifies that the lesion was rubbed persistently (lichen simplex chronicus). 10.20.3A: Nodular dermatitis, granul…