Histologic Diagnosis of Inflammatory Skin Diseases

Images

…ect sometimes bursts and becomes subepidermal, too. Within the epidermis, ballooned keratocytes can be seen in zones of incipient epidermal necrosis, an inference based on the pink, rather than the usual blue, hue of the epidermis. Note that the derm…

Histologic Diagnosis of Inflammatory Skin Diseases

Errors and Reasons

…so-called apocrine miliaria, spongiosis occurs in infundibular epidermis, whereas in miliaria rubra it appears in surface epidermis; Fox-Fordyce disease presents itself, clinically and histopathologically, as a plug of horn (cornified cells) in infun…

Histologic Diagnosis of Inflammatory Skin Diseases

Hair Follicles

…he infundibulum is not a component of the follicle, but of the epidermis, it being virtually identical histologically to surface epidermis. The lowest part of a follicle is named the bulb because it resembles the bulb of a tulip or an onion (Fig. 1.2…

Histologic Diagnosis of Inflammatory Skin Diseases

Lupus erythematosus

…cuolar alteration Basement membrane between dermis and surface epidermis, infundibular epidermis, and the uppermost part of the dermal eccrine ducts thickened markedly Surface epidermis thinned, sometimes severely, and hyperkeratotic, i.e., ortho- an…

Histologic Diagnosis of Inflammatory Skin Diseases

Images

…ratocytes in company with neutrophils in the upper half of the epidermis = Irritant contact dermatitis Severe ballooning of keratocytes confined to the upper half of the epidermis indicates that the lesion was induced by injury external. Karyolys…

Histologic Diagnosis of Inflammatory Skin Diseases

Images

…es of collagen in haphazard array, and, in continuity with the epidermis, many follicular papillae and contiguous primitive follicles = Dermatofibroma Induction of follicles (and sebaceous units) from epidermis occurs during the histiocytic stage of…

Histologic Diagnosis of Inflammatory Skin Diseases

Images

…rmis, lymphocytes along the dermoepidermal junction and in the epidermis, spongiosis, ballooning, pallor across viable epidermis, and scale-crusts = Mucha-Habermann disease, acute ¬†All the changes pictured have occurred beneath the original normal co…

Histologic Diagnosis of Inflammatory Skin Diseases

Hailey-Hailey disease

…r and, in some foci, throughout at least the lower half of the epidermis Infundibular epidermis and epithelial structures of adnexa spared by the acantholytic process Scale-crusts Late All the features of fully developed lesions with the addition o…

Histologic Diagnosis of Inflammatory Skin Diseases

"Folliculitis" (Infundibulitis)

…acantholytic cells in what, at first, was a blister in surface epidermis. Episodically, infection by herpesvirus may be centered in infundibular epidermis. Clues to specific diagnosis histopathologic Neutrophils in a discrete focus in what appears…