Histologic Diagnosis of Inflammatory Skin Diseases

Radiation dermatitis and panniculitis

Radiation dermatitis and panniculitis Synonyms Radiodermatitis Presentation stereotypical Age and sex Adults of both sexes Distribution of lesions At a site of previous radiation Individual lesions Poikilodermatous patches and ulcers Course Protract…

Clinical Case Studies

Graft-Versus-Host Disease

INITIAL PRESENTATION A 38-year-old Filipino male presented with lichen planus-like plaques and dyspigmentation of the hands, lips, and oral mucosa. Eight months earlier he had received an allogeneic bone marrow transplant for the treatment of a hema…

Histologic Diagnosis of Inflammatory Skin Diseases

Identification of Basic Patterns: Skin: Vasculitis

See Fig. 5.218 A&B. Figure 5.218 Vasculitis. A. Small vessel. B. Large vessel. Before a reasoned and reasonable method for diagnosis histopathologic of vasculitis in skin and subcutaneous fat can be formulated, a definition of vasculitis must…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Primary and Secondary Lesions?

“Some of the appearances observed in cutaneous diseases are caused directly by the deposition of morbid products in the skin. These bear the name of Primary symptoms or eruptions, Efflorescentiae cutaneae primariae. But these eruptions often…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Chondrodermatitis Nodularis Helicis?

“At the dermatology meeting in Berlin, Jadassohn also indicated that changes in the cartilage can often be established clinically, especially the knobby sites on the helix that show a whitish transparence through a thinned epidermis. My expe…

Differential Diagnosis in Dermatopathology

Differential Diagnosis

…sis fungoides, plaque 1. Papules and nodules 1. Plaques 2. Erosion and/or ulceration common 2. No erosion or ulceration usually 3. Parakeratosis often contains neutrophils 3. Ortho- and parakeratosis; no neutrophils 4. Wedge-shaped necrosis a…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Diabetic Dermopathy?

“Retinopathy, neuropathy and nephropathy of the diabetic syndrome are well known. The same or similar pathological process in the dermis should be called dermopathy. Dermopathy with its disease of small blood vessels, supports and extends Bu…

Histologic Diagnosis of Inflammatory Skin Diseases

Images

Images 10.45.1A: Vesicular dermatitis, intraepidermal, acantholytic + 10.45.1B: Suprabasal separation with acantholytic dyskeratotic cells throughout most of the thickness of the thickened epidermis = Hailey-Hailey disease Because when th…

Dermatology Practical & Conceptual

From the Dermatologikum Hamburg: Quiz

The patient A 78-year-old man presented with a keratotic and crusted plaque on the scalp (Figure 1). He had a history of multiple actinic keratoses with various attempts at treatment. The lesion was excised under the clinical diagnosis of squamous c…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Paraneoplastic Pemphigus?

“In summary, we suggest the following five criteria to define paraneoplastic pemphigus: painful mucosal erosions and a polymorphous skin eruption, with popular lesions progressing to blisters and erosive lesions affecting the trunk, extremiti…