Therapeutic Strategies in Dermatology

Drug Eruptions: Therapy

Therapy First-line therapy: Prompt identification and discontinuation of the offending agent is an essential first step. In most cases, the cutaneous reaction will resolve in 2-5 days without therapy; patients may continue to get new lesions during…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Ichthyoses?

…in the very same year, i.e., 1966), they considered psoriatic erythroderma to be a type of ichthyosis; they categorized the epidermal nevus termed “bullous congenital ichthyosiform erythroderma,” which they designated “epidermolyti…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Erythrodermas—Nonspecific Histopathologically?

…he non-specific changes induced by the inflammatory process of erythroderma.” Akhyani M, Ghodsi ZS, Toosi S, Dabbaghian H. Erythroderma: a clinical study of 97 cases. BMC Dermatol 2005 9;5(1):5. The preceding quotations, more than 35 years ap…

Differential Diagnosis in Dermatopathology

Discussions

The erythroderma of psoriasis and the erythroderma of mycosis fungoides have several attributes histopathologic in common: psoriasiform acanthosis, an infiltrate in the dermis that consists mostly of lymphocytes and is situated especially around and…

Histologic Diagnosis of Inflammatory Skin Diseases

Psoriasis

…ues, but as involvement of the skin universally, the result is erythroderma. In the case of psoriasis, the erythroderma is exfoliative because the disease is accompanied by countless scales. Biopsy of psoriatic erythroderma reveals changes indistingu…

Histologic Diagnosis of Inflammatory Skin Diseases

Mycosis fungoides

…the situation of mycosis fungicides with epithelial mucinosis Erythroderma of psoriasis, pityriasis rubra pilaris, and a drug eruption may be indistinguishable from the erythroderma of S├ęzary’s syndrome. Findings histopathologic “Early&…

Differential Diagnosis in Dermatopathology

Discussions

…dion or a baked apple. Shedding of this shiny membrane reveals erythroderma and large, plate-like scales that are widespread. Non-bullous congenital ichthyosiform erythroderma is not an expression of authentic ichthyosis, but an inflammatory disease,…

Histologic Diagnosis of Inflammatory Skin Diseases

Pityriasis rubra pilaris

…st, but sometimes becoming confluent, even to the extent of an erythroderma within which “islands of normal skin” seem to be preserved Individual lesions Infundibulocentric papules, papules between infundibula, plaques, erythroderma, and…

Differential Diagnosis in Dermatopathology

Ichthyosis vulgaris vs. X-linked ichthyosis

A keratotic condition of the palms and soles, inherited usually, but sometimes acquired, in which involvement may be diffuse, circumscribed (including striate), or punctate….