Therapeutic Strategies in Dermatology

Drug Eruptions: Therapy

Therapy First-line therapy: Prompt identification and discontinuation of the offending agent is an essential first step. In most cases, the cutaneous reaction will resolve in 2-5 days without therapy; patients may continue to get new lesions during…

Therapeutic Strategies in Dermatology

Sarcoidosis: Key Points

Key Points Sarcoidosis is a multisystem inflammatory disease, characterized by non-caseating granulomas, which occurs in patients of all ages and ethnic groups. Patients require thorough evaluation for multisystem disease and close monitoring for t…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Ichthyoses?

…stic reticular pattern in histological sections. Psoriasiform erythroderma is clinically and histologically indistinguishable from universal psoriasis.” Frost P, Van Scott EJ. Ichthyosiform dermatoses. Arch Dermatol 1966;94:113–26. “The…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Erythrodermas—Nonspecific Histopathologically?

…e non-specific changes induced by the inflammatory process of erythroderma.” Akhyani M, Ghodsi ZS, Toosi S, Dabbaghian H. Erythroderma: a clinical study of 97 cases. BMC Dermatol 2005 9;5(1):5. The preceding quotations, more than 35 years apa…

Differential Diagnosis in Dermatopathology

Discussions

The erythroderma of psoriasis and the erythroderma of mycosis fungoides have several attributes histopathologic in common: psoriasiform acanthosis, an infiltrate in the dermis that consists mostly of lymphocytes and is situated especially around and…

Histologic Diagnosis of Inflammatory Skin Diseases

Psoriasis

…Localized, e.g., single papule or plaque, or universal, i.e., erythroderma; between these extremes, a preference for elbows and knees, scalp, and genitalia; sometimes, widespread drop-sized (guttate) scaly papules, especially in children and young ad…

Histologic Diagnosis of Inflammatory Skin Diseases

Mycosis fungoides

…on occasion, being widespread. Sézary’s syndrome is an erythrodermatous manifestation of mycosis fungoides associated with lymphadenopathy and circulating lymphocytes whose nucleus is abnormal in its cerebriform convolution. Differential diagn…

Differential Diagnosis in Dermatopathology

Ichthyosis vulgaris vs. X-linked ichthyosis

A systemic lymphoma of T-lymphocytes that manifests itself first in the skin as macules and then patches that often are scaly. Most people with the disease have only scaly macules and patches for a lifetime, but some patients may develop papules, pl…

Histologic Diagnosis of Inflammatory Skin Diseases

Pityriasis rubra pilaris

…t, but sometimes becoming confluent, even to the extent of an erythroderma within which “islands of normal skin” seem to be preserved Individual lesions Infundibulocentric papules, papules between infundibula, plaques, erythroderma, and p…