Therapeutic Strategies in Dermatology

Histiocytosis X/Langerhans Cell Histiocytoses: Overview

…e accumulation or proliferation of a clonal population of cells bearing the phenotype of a Langerhans cell that has been arrested at an early stage of activation and is functionally deficient. This disorder is classified as single-system disease, mul…

Therapeutic Strategies in Dermatology

Darier’s Disease: Treatment

Treatment First-line therapy: The first-line therapy for Darier’s disease is systemic retinoids. First steps The currently accepted primary treatment of moderate-to-severe Darier’s disease is systemic retinoids. Isotretinoin and acitretin are equal…

Therapeutic Strategies in Dermatology

Cicatricial Pemphigoid: Overview

…carring and to control the symptoms or the nutritional problems caused by mucous membrane lesions. Unfortunately, cicatricial pemphigoid is difficult to treat, and blindness may not always be avoided. Treatment First Steps For oral disease apply sup…

Therapeutic Strategies in Dermatology

Pruritus Ani: Overview

…o have two probable causes. One is irritation from rectal mucus and fecal material. The other is nerve impingement in the sacral region causing neuropathic itch. Rarely, pinworms, contact dermatitis, extramammary Pagets disease, and streptococ…

Therapeutic Strategies in Dermatology

Candidiasis: Treatment

…efit from addition of a low-to- medium potency topical corticosteroid to alleviate inflammation associated with candidal superinfection. Refractory lesions may need a biopsy to rule out extramammary Pagets disease, squamous cell carcinoma in s

Therapeutic Strategies in Dermatology

Candidiasis: Key Points

…allergic or irritant contact dermatitis, deficiency dermatitis, Hailey-Hailey or Darier’s disease, axillary granular parakeratosis, Kawasaki syndrome, as well as cutaneous malignancies such as squamous cell carcinoma, extramammary Paget’…

Therapeutic Strategies in Dermatology

Candidiasis: Initial Evaluation

…ential diagnosis Inverse pityriasis rosea Deficiency dermatitis (such as zinc deficiency, aka acrodermatitis enteropathica) Allergic or irritant contact dermatitis Inverse psoriasis Tinea cruris Extramammary Pagets disease

Differential Diagnosis in Dermatopathology

Pagetoid Bowen’s disease vs. Extramammary Paget’s disease

An inflammatory disease caused by the spirochete Borrelia burgdorferi that manifests itself in the skin as erythematous lesions with figurate shapes, e.g., (round, ellipsoid, and arcuate) (erythema chronicum migrans), pseudolymphomatous nodules (lym…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Mammary and Extramammary Paget’s Disease?

Extramammary Pagets disease is a carcinoma of the ducts of apocrine sweat glands, with the invasion of carcinoma cells (Pagets cells) into the epidermis and into the glandular portion of the sweat gland.” Braun-Falco O,…