Therapeutic Strategies in Dermatology

Histiocytosis X/Langerhans Cell Histiocytoses: Overview

…notype of a Langerhans cell that has been arrested at an early stage of activation and is functionally deficient. This disorder is classified as single-system disease, multisystem disease, or multisystem disease with organ dysfunction. The skin is on…

Therapeutic Strategies in Dermatology

Darier’s Disease: Treatment

…atment First-line therapy: The first-line therapy for Darier’s disease is systemic retinoids. First steps The currently accepted primary treatment of moderate-to-severe Darier’s disease is systemic retinoids. Isotretinoin and acitretin are equally e…

Therapeutic Strategies in Dermatology

Cicatricial Pemphigoid: Overview

…reat, and blindness may not always be avoided. Treatment First Steps For oral disease apply superpotent topical steroids in ointment base or Orobase to affected areas. For gingival disease, dental trays filled with corticosteroid ointment worn for 6…

Therapeutic Strategies in Dermatology

Pruritus Ani: Overview

…ucus and fecal material. The other is nerve impingement in the sacral region causing neuropathic itch. Rarely, pinworms, contact dermatitis, extramammary Pagets disease, and streptococcal proctitis can cause perianal itching with minimal chang…

Therapeutic Strategies in Dermatology

Candidiasis: Treatment

…ticosteroid to alleviate inflammation associated with candidal superinfection. Refractory lesions may need a biopsy to rule out extramammary Pagets disease, squamous cell carcinoma in situ (Bowen’s disease), and metabolic and other infla…

Therapeutic Strategies in Dermatology

Candidiasis: Key Points

…atitis, deficiency dermatitis, Hailey-Hailey or Darier’s disease, axillary granular parakeratosis, Kawasaki syndrome, as well as cutaneous malignancies such as squamous cell carcinoma, extramammary Pagets disease, or histiocytosis. It is

Therapeutic Strategies in Dermatology

Candidiasis: Initial Evaluation

Initial Evaluation Candidiasis Intertriginous Oral Paronychia Differential diagnosis Inverse pityriasis rosea Deficiency dermatitis (such as zinc deficiency, aka acrodermatitis enteropathica) Allergic or irritant cont…

Differential Diagnosis in Dermatopathology

Pagetoid Bowen’s disease vs. Extramammary Paget’s disease

An inflammatory disease caused by the spirochete Borrelia burgdorferi that manifests itself in the skin as erythematous lesions with figurate shapes, e.g., (round, ellipsoid, and arcuate) (erythema chronicum migrans), pseudolymphomatous nodules (lym…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Mammary and Extramammary Paget’s Disease?

…aductal adenocarcinoma in the breasts, the histogenesis of the extramammary type remains controversial.” Weedon D, Strutton G. Skin Pathology. 2nd ed. New York: Churchill-Livingstone, 2002. Mammary and extramammary Pagets disease are…