Search Results for: fibrin

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Mucha-Habermann Disease a Lymphocytic Vasculitis?

…(venules nearly always) are characterized by the presence of fibrin in the wall and/or thrombi in the lumen in the context of an infiltrate of inflammatory cells. In the vast majority of instances, the cells are neutrophils, e.g., in leukocytoclasti…

Histologic Diagnosis of Inflammatory Skin Diseases

Leukocytoclastic vasculitis

…oo. Neutrophils sometimes form collections in dermal papillae Fibrin in the wall of venules in the reticular dermis and, sometimes, in venules in septa in the subcutaneous fat Erythrocytes extravasated in variable number, often numerous, in the upper…

Differential Diagnosis in Dermatopathology

Subcutaneous granuloma annulare vs. Rheumatoid nodule

A type of small-vessel vasculitis (venulitis) of the skin, occurring especially in the vicinity of the ankle, characterized at first by purpuric macules and patches that, in time, may become hemorrhagic blisters that ulcerate and heal with white, st…

Histologic Diagnosis of Inflammatory Skin Diseases

Confusing Terms (to be Avoided Scrupulously)

…t is now appreciated that “toxic hyaline” is just fibrin. “Hyaline globules” is a name given to degenerating erythrocytes lodged in lysosomes of endothelial cells in some lesions of Kaposi’s sarcoma. “Hyaline bodie…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Atrophie Blanche?

…a vasculopathy in which occlusion of small dermal vessels by fibrin thrombi is the primary event. It appears to result from described fibrinolytic activity of the blood with defective release of tissue plasminogen activator from vessel walls.”…

Histologic Diagnosis of Inflammatory Skin Diseases

Septic vasculitis

…is histopathologic Leukocytoclastic vasculitis is typified by fibrin in the wall of venules and by absence of thrombi from lumen of them, abundant nuclear “dust” of neutrophils, and often some eosinophils in the infiltrate. Only venules a…

Histologic Diagnosis of Inflammatory Skin Diseases

Images

…the junction by inflammatory cells, and hints of subepidermal fibrin = Linear IgA dermatosis Findings just like these may be seen in dermatitis herpetiformis. 10.19.2A: Vesicular dermatitis, subepidermal, neutrophils predominant + 10.19.2B: Neutrophi…

Histologic Diagnosis of Inflammatory Skin Diseases

Granuloma annulare

…Copious mucin, sometimes in company with variable amounts of fibrin and of degenerated bundles of collagen, in the center of palisaded granulomas and in association with histiocytes scattered interstitially Neutrophils and nuclear “dust”…

Histologic Diagnosis of Inflammatory Skin Diseases

Radiation dermatitis and panniculitis

…rates around venules in at least the upper part of the dermis Fibrin thrombi in venules in the dermis and, sometimes, in the subcutaneous fat Sclerosis throughout at least the upper part of the dermis and, sometimes, throughout the entire dermis and…