Histologic Diagnosis of Inflammatory Skin Diseases

Introduction

…mbers are scattered throughout the mature dermis, those being fibrocytes, dermal dendrocytes, histiocytes, Langerhans” cells, and mast cells. Within the dermis are housed nerves, blood vessels, lymph vessels, smooth muscles, and epithelial stru…

Histologic Diagnosis of Inflammatory Skin Diseases

Hair Follicles

…minantly Type III. Scattered in the perifollicular sheath are fibrocytes that are responsible for producing it and capillaries that are aligned parallel to bundles of collagen in the outer component of it. A “glassy” basement membrane, pe…

Histologic Diagnosis of Inflammatory Skin Diseases

Macular and papular (lichenoid) amyloidosis-Cutaneous solely

…l pink material (amyloid) in widened dermal papillae Stellate fibrocytes in the vicinity of the globules Individual necrotic keratocytes in the spinous layer of the epidermis Fully developed More melanophages and more numerous globules of amyloid t…

Histologic Diagnosis of Inflammatory Skin Diseases

Images

…mucin in company with scattered spindle- and stellate-shaped fibrocytes, as well as mast cells = Scleromyxedema, early  This is an early lesion because mucin is so abundant in the reticular dermis. A synonym for the condition is papular mucinosis, a…

Histologic Diagnosis of Inflammatory Skin Diseases

Images

….70.2B: Interwoven fascicles of plump oval and spindle-shaped fibrocytes in conjunction with fibrillary bundles of collagen, abundant mucin, scattered lymphocytes, and extravasated erythrocytes = Nodular fasciitis  This condition fundamentally is fib…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Metastasizing Dermatofibroma?

…n consists entirely of inflammatory cells, i.e., histiocytes, fibrocytes, and sometimes lymphocytes. At the outset, many erythrocytes are extravasated consequent to the effects of the initiating trauma, and products of them are ingested by macrophage…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Dermal Papilla?

…f elastic fibers, scant mucin, few capillaries, and scattered fibrocytes. The vasculature in the reticular dermis is formed principally of two plexuses (made up of venules and arterioles) arranged parallel to each other, the superficial plexus residi…