Histologic Diagnosis of Inflammatory Skin Diseases

Hair Follicles

Morphologic and qualitative differences in hair, a cornified end-product of matrical cells positioned in the center of a follicular bulb, exist among the races of Man. In general, Caucasians have the most prominent hair, Asians have the least, and A…

Histologic Diagnosis of Inflammatory Skin Diseases

Macular and papular (lichenoid) amyloidosis-Cutaneous solely

Macular and papular (lichenoid) amyloidosis—Cutaneous solely Presentation stereotypical Age and sex Women of Asian, Latin, or Middle Eastern ancestry usually Distribution of lesions Macular form most common in the interscapular region, but also seen…

Histologic Diagnosis of Inflammatory Skin Diseases

Images

Images 11.18.1A: Perivascular and interstitial dermatosis + 11.18.1B: Large amount of mucin in company with scattered spindle- and stellate-shaped fibrocytes, as well as mast cells = Scleromyxedema, early  This is an early lesion because…

Histologic Diagnosis of Inflammatory Skin Diseases

Introduction

Capability for accurate diagnosis of inflammatory skin diseases, clinically and histopathologically, requires familiarity thoroughly with embryologic, histologic, and anatomic aspects of the skin. Although examples of this precept are legion, only a…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Dermal Papilla?

“Historically, the hair germ has been defined as a group of cells located at the base of the telogen follicle in close contact with the dermal papilla.” Lavker RM, Miller S, Wilson C, et al. Hair follicle stem cells: their location, ro…

Histologic Diagnosis of Inflammatory Skin Diseases

Images

Images 10.70.1A: Panniculitis, septal mostly + 10.70.1B: Fibrosing granulation tissue, abundant mucin, and scattered lymphocytes = Nodular fasciitis  The changes pictured are a response to external trauma akin to those in an early stage o…

Differential Diagnosis in Dermatopathology

Discussions

…term histiocytoma has been employed. When both histiocytes and fibrocytes are numerous, the lesion sometimes is called a fibrous histiocytoma. To very old lesions in which fibrocytes are decreased in number and bundles of collagen have become somewha…