Histologic Diagnosis of Inflammatory Skin Diseases

Images

…tis, suppurative granulomatous + 10.94.2B: Predominance of histiocytes in foci, neutrophils scattered among histiocytes, and a lymphoplasmacytic infiltrate around venules = Rosacea, papular  That the inflammatory process has destroyed some infund…

Histologic Diagnosis of Inflammatory Skin Diseases

Necrobiosis lipoidica

…ells along thickened septa in the subcutaneous fat Epithelioid histiocytes, some multinucleate, around blood vessels throughout the dermis and in thickened septa of the subcutaneous fat; some histiocytes impinging on vessels and present in the wall o…

Histologic Diagnosis of Inflammatory Skin Diseases

Interstitial granulomatous dermatitis with arthritis

…n widened septa in the upper part of the subcutaneous fat Some histiocytes with large nuclei and some in mitosis Eosinophils and neutrophils in number variable scattered throughout the infiltrate of histiocytes In foci, degeneration of a few collagen…

Histologic Diagnosis of Inflammatory Skin Diseases

Identification of Basic Patterns: Skin: Perivascular Dermatitis

…perivascular and interstitial infiltrate in which epithelioid histiocytes predominate in the interstitium and lymphocytes surround venules is met with in granuloma annulare (Fig. 5.33 A&B). When the histiocytes are accompanied by neutrophils and…

Histologic Diagnosis of Inflammatory Skin Diseases

Granuloma annulare

…filtrate of lymphocytes In small foci in the reticular dermis, histiocytes in palisaded and/or interstitial array Mucin discernible in foci in which histiocytes predominate Fully developed—dermal granuloma annulare Same findings as in early lesions…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Granulomatous Mycosis Fungoides?

…s of elastic fibers are noted consistently in the cytoplasm of histiocytes, often multinucleate ones, in lesions of mycosis fungoides that are associated with granulomatous inflammation. Some fragments of elastic fibers situated in histiocytes may un…

Histologic Diagnosis of Inflammatory Skin Diseases

Images

…11.14.24B: Abnormal lymphocytes, small lymphocytes, and many histiocytes in nodules = Mycosis fungoides, plaque  A psoriasiform nodular pattern in which lymphocytes predominate is virtually diagnostic of mycosis fungoides. The numerous epithelioid…

Histologic Diagnosis of Inflammatory Skin Diseases

Images

…3B: Predominance of plasma cells in a mixed-cell infiltrate of histiocytes, lymphocytes, and numerous neutrophils = Syphilis, secondary  Adnexocentricity of the infiltrate of histiocytes and plasma cells in the reticular dermis is common in secondary…