Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Id Reactions?

…thentic lesions of secondary syphilis that house the causative spirochetes. Bacterids, diagnosed with enthusiasm in the 1940s, were pustular lesions on the palms and soles purported to have resulted from “foci of infection” in teeth, tons

Histologic Diagnosis of Inflammatory Skin Diseases

Our Definition of “Inflammation” and “Inflammatory Disease”

…an infiltrate of inflammatory cells and, at times, by changes secondary to the effects of them, such as spongiosis, acanthosis, and fibroplasia, that infiltrate being unaffiliated with cells of any other fundamental pathologic process, such as neopl…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Inverted Follicular Keratosis, Tricholemmoma, and Desmoplastic Tricholemmoma?

…erving a lesion—a keratosis—which occurs mostly on the face: I should say about 90 percent on the face, the remainder on other parts of the body. These lesions are characterized clinically by a papule or nodule, practically always single and usually…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Mycosis Fungoides—Increasing in Incidence?

…able, reliable morphologic criteria, to diagnose melanoma at a stage when that neoplasm is still flat (rather than by a variety of circumlocutions for it like Hutchinsons melanotic freckle, precancerous circumscribed melanosis of Dubreuilh, an…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Anagen Effluvium?

…uvium, but these had atypical features.” Berth-Jones J, Shuttleworth D, Hutchinson PE. A study of etretinate alopecia. Br J Dermatol 1990;122(6):751–55. “More serious damage to anagen follicles, and perhaps also greater sensitivity to c…

Histologic Diagnosis of Inflammatory Skin Diseases

Ecthyma gangrenosum

Ecthyma gangrenosum Presentation stereotypical Age and sex Any age, both sexes; usually in chronically or terminally ill patients or those vulnerable to Pseudomonas septicemia Distribution of lesions Anogenital and axillary regions especially Shape…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Precursor Lesions of Melanoma?

…“Precursors of melanoma are lesions that are benign per se but have the potential of turning malignant and thus giving rise to melanoma. Two such entities are recognized: (1) atypical nevomelanocytic proliferation, and (2) congenital nevomelan…

Histologic Diagnosis of Inflammatory Skin Diseases

Incontinentia pigmenti

…in association with atrophy Variations clinical This disorder sometimes occurs in combination with various abnormalities congenital, particularly of the central nervous system, bone, and teeth Differential diagnosis clinical Vesicular stage: Epider…

Differential Diagnosis in Dermatopathology

Leukokeratosis vs. Leukoplakia

An inflammatory process that appears on skin exposed to sunlight, especially the face, neck, sternal region, arms, and dorsa of hands, and consists mostly of edematous papules that may become confluent to form plaques, and at times, papulovesicles….

Differential Diagnosis in Dermatopathology

Discussions

Leukokeratosis and leukoplakia are white, slightly elevated nonindurated lesions of the mucosae (especially of the mouth, but also of the vagina and other areas) that also have some attributes histopathologic in common, namely, hyperkeratosis, a thi…