Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Cytophagic Panniculitis?

…ar [sic] panniculitis and fat necrosis, together with massive hyaline necrosis, oedema, and haemorrhage. Diagnosis In its later stages the condition is distinguished from malignant histiocytosis by its chronic course and a benign appearance of the hi…

Differential Diagnosis in Dermatopathology

Differential Diagnosis

…sse 8. Few mitotic figures 8. Many mitotic figures 9. No hyaline globules 9. Hyaline globules in some endothelial cells 10. Few plasma cells 10. Many plasma cells 11. No thin-walled, bizarre-shaped vessels 11. Bizarre-shaped vessels lined by…

Dermatology Practical & Conceptual

Tufted hemangioma: clinical case and literature review

…thelioid cells surrounded by slit-like vascular lumina. Small hyaline globules are noted. Hematoxylin and eosin stain, x600. [Copyright: ©2014 Kazlouskaya et al.] Cracked irregular spaces were seen between the cells in the proliferation (Figure 5). S…

Dermatology Practical & Conceptual

Widespread pruritic papules on the trunk and extremities

…rved. An additional finding was the presence of eosinophilic, hyaline, homogeneous deposits confined to the papillary dermis, which showed metachromatic staining with crystal violet. Sparse melanophages were observed in the dermis. The vessels of the…

Histologic Diagnosis of Inflammatory Skin Diseases

Dermatofibroma

…cells arranged in fascicles that interweave; often, tiny pink hyaline globules that represent degenerated erythrocytes are found in hyperplastic endothelial cells. Malignant fibrous histiocytoma is affiliated with many mitotic figures, some of them a…

Dermatology Practical & Conceptual

Dermatoscopic pattern of a cylindroma

…cular nuclei. Each lobule is outlined by a dense PAS-positive hyaline membrane. [Copyright: ©2014 Cohen et al.] Discussion Cylindromas are slowly growing benign adnexal tumors that occur most commonly on the head, neck, and scalp.  They can occur as…

Differential Diagnosis in Dermatopathology

Discussions

…. As might be expected, necrotic keratocytes (Civatte bodies, hyaline bodies, colloid bodies, apoptotic cells) are seen often in lichen planus-like keratosis. Sometimes the pink globules are present in the papillary dermis, too. It would seem correct…

Differential Diagnosis in Dermatopathology

Discussions

…n as pink globules of various sizes, they are known as “hyaline globules.” Those globules represent erythrophagocytosis and are virtually pathognomonic of Kaposi’s sarcoma. Kaposi’s sarcoma is purported to occur in three disti…