Histologic Diagnosis of Inflammatory Skin Diseases

Identification of Basic Patterns: Skin: Fibrosing Dermatitis

…esult of the effects on fibrocytes of a longstanding lichenoid infiltrate of an inflammatory process (acrodermatitis chronica atrophicans). The broad lichenoid lymphoplasmacytic infiltrate of acrodermatitis chronica atrophicans of long duration induc…

Histologic Diagnosis of Inflammatory Skin Diseases

Identification of Basic Patterns: Skin: Vasculitis

…nifested by at least two different patterns: In one, the mixed infiltrate of inflammatory cells is confined largely to the large vessel itself (Fig. 5.237 A&B), e.g., one manifestation of polyarteritis nodosa, and in the other, the mixed-cell inf…

Histologic Diagnosis of Inflammatory Skin Diseases

Images

….14.9B: Epithelial (infundibular) mucinosis in company with an infiltrate of small lymphocytes and eosinophils = Mycosis fungoides, alopecia mucinosa expression  The infiltrate is present not only in the dermis, but also in infundibula and follicles,…

Histologic Diagnosis of Inflammatory Skin Diseases

Identification of Basic Patterns: Skin: Vesicular Dermatitis

…including features clinical and history. The character of the infiltrate is not crucial to enabling diagnosis of an intraepidermal vesicular dermatitis to be reached with certainty; the infiltrate may be monomorphous (Fig. 5.242 A&B) or mixed (F…

Histologic Diagnosis of Inflammatory Skin Diseases

Images

…+ 10.103.3B: Predominance of plasma cells in a mixed-cell infiltrate of histiocytes, lymphocytes, and numerous neutrophils = Syphilis, secondary  Adnexocentricity of the infiltrate of histiocytes and plasma cells in the reticular dermis is commo…

Histologic Diagnosis of Inflammatory Skin Diseases

Xanthogranuloma

…us Some histiocytes in mitosis Fully developed Dense diffuse infiltrate of histiocytes Many histiocytes with foamy cytoplasm Some histiocytes Touton in type; many of them sometimes Infiltrate of histiocytes sometimes abutting the epidermis and caus…

Histologic Diagnosis of Inflammatory Skin Diseases

Images

…tis and perifolliculitis, fibrosing + 10.60.13B: Lichenoid infiltrate of lymphocytes and clefts between the infiltrate and the thinned infundibula and follicles = Lichen planopilaris  In addition to the lichenoid infiltrate of lymphocytes that su…

Histologic Diagnosis of Inflammatory Skin Diseases

Lymphocytoma cutis

…ors of B-cell lymphoma Fully developed Nodular and/or diffuse infiltrate made up mostly of small lymphocytes in the reticular dermis and, sometimes, in the upper part of the subcutaneous fat Infiltrate usually denser in the upper part (“top he…

Histologic Diagnosis of Inflammatory Skin Diseases

Graft-versus-host disease/Eruption of lymphocyte recovery

…rakeratosis or both Fully developed Superficial perivascular infiltrate of lymphocytes Lichenoid infiltrate of lymphocytes in association with vacuolar alteration obscures the dermoepidermal junction Epidermis thinned, often severely, with loss of…

Histologic Diagnosis of Inflammatory Skin Diseases

Images

…rved, along with solar elastosis, at the side of the lichenoid infiltrate. The products of lymphocytes destroy the solar lentigo, the lesion in the process of being decimated then being called lichen planus-like keratosis. The lichenoid infiltrate of…