Histologic Diagnosis of Inflammatory Skin Diseases

Images

Images 10.60.1A: Perivascular dermatitis, interface, focally lichenoid + 10.60.1B: Obscuration of the dermoepidermal junction by lymphocytes, jagged acanthosis, wedge-shaped hypergranulosis, and compact orthokeratosis = Lichen planus, ear…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Pityrosporum Folliculitis and Demodectic Folliculitis?

…topathologists must disabuse themselves of the notion that the infundibulum is part of the follicle when, in actuality, it is epidermis in continuity with the follicle. The infiltrates of inflammatory cells, neutrophils usually, within an infundibulu…

Histologic Diagnosis of Inflammatory Skin Diseases

Pyoderma gangrenosum

…ils mostly; lymphocytes around venules Neutrophils filling the infundibulum Remnants of infundibular epithelium in and around an abscess in the reticular dermis, a sign of rupture of an infundibulum stuffed with neutrophils Subcorneal pustule, if pre…

Histologic Diagnosis of Inflammatory Skin Diseases

Applicable Terms

ABSCESS [L. abscessus (a going away)]: Clinically, a circumscribed collection of pus and histopathologically a localized collection of neutrophils. An abscess may form in the epidermis, both surface and infundibular, eccrine ducts, dermis, and subcu…

Histologic Diagnosis of Inflammatory Skin Diseases

Images

…11.10.1A: Infundibular plug of corneocytes in a widened infundibulum + 11.10.1B: A cast of parakeratotic cells in the dilated infundibulum = Keratosis pilaris ┬áChanges identical to these are seen in lichen spinulosus, a variant clinical of…

Histologic Diagnosis of Inflammatory Skin Diseases

Lichen planus

Lichen planus Synonyms Lichen ruber planus Lichen ruber Presentation stereotypical Age and sex More common in women, especially young and middle-aged adults Distribution of lesions Flexor surface of forearms and wrists, but no site is exempt. Occu…

Histologic Diagnosis of Inflammatory Skin Diseases

Images

…8217;s granuloma) The hair was spewed into the dermis when an infundibulum, stuffed with neutrophils, ruptured. The incipient granulomatous inflammation represents a foreign body reaction to contents of that infundibulum. 10.38.2A: Pustular de…

Histologic Diagnosis of Inflammatory Skin Diseases

Images

Images 11.14.1A: Perivascular dermatosis, psoriasiform lichenoid + 11.14.1B: Lymphocytes, sparse in both the dermis and epidermis, larger in the epidermis than in dermis, solitary in the basal layer in foci, and in association with scant…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Eruptive Vellus Hair Cyst?

…hose two epithelia being identical), but also like that of the infundibulum of epidermis, the infundibulum and isthmus being in continuity normally. In short, cutaneous cysts, cystic hamartomas, and cystic neoplasms may display more than one type of…

Histologic Diagnosis of Inflammatory Skin Diseases

Pattern Analysis in Historical Perspective

In 1963, the year that one of us (A.B.A.) began a residency in dermatology, Walter Lever’s textbook, Histopathology of the Skin, was in its third edition and was deemed, universally, to be “the bible” of dermatopathology. To a firs…