Search Results for: leprosy

Histologic Diagnosis of Inflammatory Skin Diseases

Xanthomas

…hat inclusive definition applies to conditions that are inflammatory diseases, as dissimilar as some examples of lepromatous leprosy and of xanthogranulomas, and to those that are not, as unalike as xanthelasma and eruptive xanthoma. True xanthomas…

Histologic Diagnosis of Inflammatory Skin Diseases

Leishmaniasis

…ve. Sometimes, lesions ulcerate and resolve with scar. Differential diagnosis histopathologic Lupus vulgaris and tuberculoid leprosy may be indistinguishable from chronic cutaneous leishmaniasis. In tuberculoid leprosy, however, granulomas tend to…

Histologic Diagnosis of Inflammatory Skin Diseases

Algorithms Predicated on “Nonspecific” Findings

…of fibrosis (late) = Xanthogranuloma + Foamy histiocytes with gray cytoplasm (“globi”) in a nodular infiltrate = Leprosy, lepromatous, or infection by atypical mycobacteria, usually in a person immunosuppressed + Foamy histiocytes with…

Nodules on the right ear

Nodules on the right ear

…[1]. The process of dissemination lasts several decades. Clinical differential diagnosis of lobomycosis includes lepromatous leprosy, chromoblastomycosis, keloids, xanthomas, fibromas, Kaposi’s sarcoma, neurofibromas and dermatofibrosarcoma…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Inverted Follicular Keratosis, Tricholemmoma, and Desmoplastic Tricholemmoma?

…and in “tricholemmoma.” There are skeptics, of course, but that was true, too, for Hansen’s assertion that leprosy was caused by an agent infectious, namely a bacterium. The great Hutchinson insisted until his death that leprosy

Histologic Diagnosis of Inflammatory Skin Diseases

Cells That Mediate Inflammation (Inflammatory Cells)

…so may participate in granulomatous inflammation, e.g., ones with foamy cytoplasm (Fig. 2.13), as is the case in lepromatous leprosy. Based on distinctive patterns morphologic, granulomas have been classified as tuberculoid, sarcoidal, palisaded,…

Histologic Diagnosis of Inflammatory Skin Diseases

The Algorithmic Method

…theme of mixed-cell infiltrates exist. For example, histiocytes may accompany lymphocytes, as in lupus vulgaris, tuberculoid leprosy, and rosacea (see Fig. 5.346) (when histiocytes dominate, even if only in a single locus, the condition is deemed to…

Histologic Diagnosis of Inflammatory Skin Diseases

Limitations of the Algorithmic Method

…e of lymphocytes. Those changes could represent an expression of a viral exanthem, morbilliform drug eruption, indeterminate leprosy, or an early stage of vitiligo. In such a circumstance, the diagnosis histopathologic given must be descriptive,…