Histologic Diagnosis of Inflammatory Skin Diseases


…as well. Differential diagnosis histopathologic Lepromatous leprosy sometimes consists of histiocytes that are foamy, as well as granular (Virchow cells) and those may be conceived of as xanthomatous in the sense that the lipid derives from the wal…

Histologic Diagnosis of Inflammatory Skin Diseases

Identification of Basic Patterns: Skin: Nodular and Diffuse Dermatitis

…Figure 5.179 A&B. Tuberculoid granuloma in tuberculoid leprosy. Nodules composed of epithelioid histiocytes enveloped by lymphocytes and plasma cells are findings expected in a variety of infectious processes, including lupus vulgaris, the rec…

Histologic Diagnosis of Inflammatory Skin Diseases


…eishmaniasis Widespread nodules resemble those of lepromatous leprosy in persons whose immune response is deficient. Visceral leishmaniasis (kala azar) This systemic disease caused by Leishmania donovani involves the bone marrow, spleen, and liver….

Histologic Diagnosis of Inflammatory Skin Diseases

Algorithms Predicated on “Nonspecific” Findings

…ray cytoplasm (“globi”) in a nodular infiltrate = Leprosy, lepromatous, or infection by atypical mycobacteria, usually in a person immunosuppressed + Foamy histiocytes with gray cytoplasm (“globi”) and epithelioid histiocyte…

Dermatology Practical & Conceptual

Nodules on the right ear

…al differential diagnosis of lobomycosis includes lepromatous leprosy, chromoblastomycosis, keloids, xanthomas, fibromas, Kaposi’s sarcoma, neurofibromas and dermatofibrosarcoma protuberans [1]. Moreover, in our specific case, the differential…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Inverted Follicular Keratosis, Tricholemmoma, and Desmoplastic Tricholemmoma?

…se, but that was true, too, for Hansen’s assertion that leprosy was caused by an agent infectious, namely a bacterium. The great Hutchinson insisted until his death that leprosy was caused by ingestion of rotten fish. “Two parts of norma…

Histologic Diagnosis of Inflammatory Skin Diseases

Cells That Mediate Inflammation (Inflammatory Cells)

…th foamy cytoplasm (Fig. 2.13), as is the case in lepromatous leprosy. Based on distinctive patterns morphologic, granulomas have been classified as tuberculoid, sarcoidal, palisaded, interstitial, and suppurative. Different mechanisms of inflammatio…

Histologic Diagnosis of Inflammatory Skin Diseases

The Algorithmic Method

…may accompany lymphocytes, as in lupus vulgaris, tuberculoid leprosy, and rosacea (see Fig. 5.346) (when histiocytes dominate, even if only in a single locus, the condition is deemed to be “granulomatous”). When collections of neutrophil…

Histologic Diagnosis of Inflammatory Skin Diseases

Limitations of the Algorithmic Method

…f a viral exanthem, morbilliform drug eruption, indeterminate leprosy, or an early stage of vitiligo. In such a circumstance, the diagnosis histopathologic given must be descriptive, namely, “perivascular dermatitis, lymphocytic, superficial, s…