Search Results for: letterer-siwe disease

Therapeutic Strategies in Dermatology

Darier’s Disease: Treatment

…4-8 weeks), reduce the daily retinoid dose. Maintenance therapy constitutes the lowest dose that suppresses the most severe disease features. Since the disease tends to be relatively quiescent during winter months, if possible discontinue retinoid…

A Clinical Atlas of 101 Common Skin Diseases

Histiocytosis X

A proliferation of abnormal Langerhans’ cells that may affect internal organs, e.g., the spleen, liver, and bone, sometimes with fatal outcome, as well as the skin, where lesions usually manifest themselves as purpuric papules or ulcers that…

Differential Diagnosis in Dermatopathology

Pagetoid Bowen’s disease vs. Extramammary Paget’s disease

A proliferation of abnormal Langerhans’ cells that may affect internal organs, e.g., the spleen, liver, and bone, sometimes with fatal outcome, as well as the skin, where lesions usually manifest themselves as purpuric papules or ulcers that…

Histologic Diagnosis of Inflammatory Skin Diseases

Behçet’s Disease

…although it is likely that vasculitis is the reason; necrosis is consequent to occlusion of vessels affected. Sweet’s disease-like lesions in Behçet’s disease may be differentiated from those of true Sweet’s syndrome by virtue of…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Mammary and Extramammary Paget’s Disease?

…omenon, paradoxically, as “extramammary mammary Paget’s disease.” In sum, there is no single Paget’s disease. There are different diseases characterized by cells of an adenocarcinoma of apocrine character disposed as solitary…

Histologic Diagnosis of Inflammatory Skin Diseases

Grover’s disease

…derately dense infiltrate of lymphocytes is apparent at scanning magnification, the diagnosis is likely to be Grover’s disease, not Darier’s disease. However, a single focus of the Darier-like type of Grover’s disease may not be…