Histologic Diagnosis of Inflammatory Skin Diseases

Identification of Basic Patterns: Skin: Nodular and Diffuse Dermatitis

…n nodular array may be a manifestation of chronic lymphocytic leukemia or of the lymphomatous analogue of it (Fig. 5.202 A&B). Figure 5.201 A&B. Granulomatous dermatitis, not “pseudolymphoma.” At scanning power, a “top-he…

Histologic Diagnosis of Inflammatory Skin Diseases

Sweet’s syndrome

…ndrome. In some persons with Sweet’s syndrome, however, leukemia, usually acute myeloid, seems to be the factor that precipitates development of skin lesions. What the relationship is between the leukemia and the nodular infiltrate of neutrophi…

Histologic Diagnosis of Inflammatory Skin Diseases

Algorithms Predicated on “Nonspecific” Findings

…+ Atypical mononuclear cells in a dense diffuse infiltrate = Leukemia + Lymphocytes in a perivascular infiltrate = Polymorphous light eruption + In a section from volar skin, a moderately dense superficial and deep perivascular infiltrate of lym…

Histologic Diagnosis of Inflammatory Skin Diseases

Study By Disease

…onica atrophicans (borreliosis) (Quiz #150) Acute myelogenous leukemia (Quiz #612) Acute myelogenous leukemia (Quiz #626) Adenoma sebaceum (Quiz #445) Allen’s “cellular” blue nevus (Quiz #807) Allergic contact dermatitis (Quiz #29)…

Histologic Diagnosis of Inflammatory Skin Diseases

Paraneoplastic pemphigus

…suffer from a malignant neoplastic process such as lymphoma, leukemia, thymoma, or Castleman’s disease Distribution of lesions Widespread; usually severe involvement of mucosae Individual lesions Macules, patches, or papules; rarely vesicles;…

Histologic Diagnosis of Inflammatory Skin Diseases

Identification of Basic Patterns: Skin: Vesicular Dermatitis

…es (and a near lookalike of it, namely, adult T-cell lymphoma/leukemia). In mycosis fungoides, spongiosis is negligible and, for practical purposes, never progresses to vesiculation. In fact, lymphocytes in the epidermal spinous zone of a patch of my…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Paraneoplastic Pemphigus?

…on of a malignant neoplastic process, usually a lymphoma or a leukemia. Neither clinically nor histopathologically does it resemble either pemphigus vulgaris or pemphigus foliaceus. Although clinically the disease has some features in common with ery…

Histologic Diagnosis of Inflammatory Skin Diseases

Images

…s and in discrete collections in the epidermis = Adult T-cell leukemia/lymphoma  The intraepidermal clusters of abnormal lymphocytes resemble those of Pautrier’s collections in mycosis fungoides, but the lymphocytes in this disease induced by a…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Histiocytoses?

…and a cutaneous variant 2. Histiocytic lymphoma 3. Monocytic leukemia” Moschella SL, Cropley TG. Diseases of the mononuclear phagocytic system (the so-called reticuloendothelial system). In: Moschella SL, Hurley HJ, eds. Dermatology, 3rd ed. P…