Histologic Diagnosis of Inflammatory Skin Diseases

Identification of Basic Patterns: Skin: Nodular and Diffuse Dermatitis

…edominate, making this granulomatous. Figure 5.202 A&B. Leukemia cutis, not “pseudolymphoma.” This “top-heavy” nodular infiltrate of monomorphous lymphocytes is that of chronic lymphocytic leukemia. Acknowledgment must…

Histologic Diagnosis of Inflammatory Skin Diseases

Sweet’s syndrome

…yndrome. In some persons with Sweet’s syndrome, however, leukemia, usually acute myeloid, seems to be the factor that precipitates development of skin lesions. What the relationship is between the leukemia and the nodular infiltrate of neutroph…

Histologic Diagnosis of Inflammatory Skin Diseases

Algorithms Predicated on “Nonspecific” Findings

In this section, algorithms used to reach specific diagnosis are predicated on “nonspecific” findings recognized best at higher magnification. Other changes requisite for specific diagnoses, i.e., denominators that are essential, then ar…

Histologic Diagnosis of Inflammatory Skin Diseases

Study By Disease

…ronica atrophicans (borreliosis) (Quiz #150) Acute myelogenous leukemia (Quiz #612) Acute myelogenous leukemia (Quiz #626) Adenoma sebaceum (Quiz #445) Allen’s “cellular” blue nevus (Quiz #807) Allergic contact dermatitis (Quiz #29)…

Histologic Diagnosis of Inflammatory Skin Diseases

Paraneoplastic pemphigus

Paraneoplastic pemphigus Presentation stereotypical Age and sex Elderly persons who suffer from a malignant neoplastic process such as lymphoma, leukemia, thymoma, or Castleman’s disease Distribution of lesions Widespread; usually severe invol…

Histologic Diagnosis of Inflammatory Skin Diseases

Identification of Basic Patterns: Skin: Vesicular Dermatitis

See Fig. 5.239 A-C. Figure 5.239 A-C. Patterns of vesiculation: intraepidermal, subepidermal, and intra- and subepidermal. “Blister” and “vesiculobullous” are terms generic for lesions of the skin that usually are elevated…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Paraneoplastic Pemphigus?

“In summary, we suggest the following five criteria to define paraneoplastic pemphigus: painful mucosal erosions and a polymorphous skin eruption, with popular lesions progressing to blisters and erosive lesions affecting the trunk, extremiti…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Histiocytoses?

“The concept of grouping as related disorders those which feature proliferation of cytologically mature benign histiocytic elements in either localized or more widespread form will be elaborated.” Halprin KM, Lorincz AL. Disseminated x…

Histologic Diagnosis of Inflammatory Skin Diseases

Images

Images 11.2.1A: Perivascular dermatosis, lichenoid + 11.2.1B: Abnormal lymphocytes in the dermis and in discrete collections in the epidermis = Adult T-cell leukemia/lymphoma ┬áThe intraepidermal clusters of abnormal lymphocytes resemble t…