Histologic Diagnosis of Inflammatory Skin Diseases

Dermatomyositis

…athologic Early Sparse superficial perivascular infiltrate of lymphocytes and a few lymphocytes sprinkled along the dermoepidermal junction in conjunction with subtle vacuolar alteration and an occasional necrotic keratocyte Mucin increased slightly…

Histologic Diagnosis of Inflammatory Skin Diseases

Images

…the papillary dermis and epidermis, and a sparse infiltrate of lymphocytes, rather than a lichenoid one, along the dermoepidermal interface. 10.66.4A: Perivascular dermatitis, interface, vacuolar + 10.66.4B: Lymphocytes along the dermoepide…

Histologic Diagnosis of Inflammatory Skin Diseases

Identification of Basic Patterns: Skin: Vesicular Dermatitis

…e infiltrate of inflammatory cells (in this instance mixed, of lymphocytes and eosinophils) is irrelevant to coming to that diagnosis with specificity. As a rule, however, eosinophils complement lymphocytes. In most instances, the place where a blist…

Histologic Diagnosis of Inflammatory Skin Diseases

Adult T-cell leukemia/Lymphoma

…s histopathologic Fully developed Crusts often Collections of lymphocytes in the cornified layer often Collection of lymphocytes in the epidermis usually more numerous than lymphocytes arranged as solitary units there Collections of lymphocytes in t…

Histologic Diagnosis of Inflammatory Skin Diseases

Identification of Basic Patterns: Subcutaneous Fat: Panniculitis

…magnification by notation of a patchy lichenoid infiltrate of lymphocytes accompanied by wiry bundles of collagen in random array and of lymphocytes scattered in a spinous zone that displays practically no spongiosis (Fig. 5.400 A&B). Figure…

Histologic Diagnosis of Inflammatory Skin Diseases

Fixed drug eruption

…ly deep perivascular and interstitial mixed-cell infiltrate of lymphocytes around venules mostly; neutrophils and eosinophils scattered interstitially especially Edema of the papillary dermis Lymphocytes in company with neutrophils and/or eosinophils…

Histologic Diagnosis of Inflammatory Skin Diseases

Persistent pigmented purpuric dermatitis

…ficial perivascular and, sometimes, interstitial infiltrate of lymphocytes Erythrocytes extravasated in variable number in the upper part of the dermis, i.e., few to many Fully developed Moderately dense perivascular and interstitial infiltrate of…

Histologic Diagnosis of Inflammatory Skin Diseases

Lymphocytoma cutis

…ally in germinal centers, but also in the absence of them Some lymphocytes with large nuclei and some in mitosis; strikingly abnormal lymphocytes to not predominate in even a single high-power field Correlation clinicopathologic Papules and nodules…