Dermatology Practical & Conceptual

Nail matrix melanoma: consecutive cases in a general practice

…gy (Figures 4 and 5) revealed an increased number of atypical melanocytes in lentiginous array. There were prominent thick dendrites, which were visible on hematoxylin and eosin (H&E) staining because of the amount of melanin they contained. Beca…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology


…us, however, refers to any congenital or acquired neoplasm of melanocytes.” Murphy GF, Mihm MC. The skin. In: Pathologic Basis of Disease. 6th ed. Philadelphia, PA, WB Saunders Company, 1999:1174. “Nevi, or moles, are benign tumors comp…

Differential Diagnosis in Dermatopathology

Spitz’s nevus, compound type vs. Melanoma

…macules and patches mostly in the middle third of the face, vertically and horizontally, distributed symmetrically and occurring mainly in postpubescent women as a consequence of the combined effects of estrogen and ultraviolet light on melanocytes….

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Nuclear Atypia, Cytoplasmic Atypia, and Architectural Atypia?

“The cytologically atypical melanocytes have the same features as cytologically atypical cells in any neoplastic system. Such cells are larger than normal melanocytes or the intraepidermal melanocytes of an ordinary melanocytic nevus.”…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Persistent Lentiginous Melanocytic Hyperplasia, Atypical Melanocytic Hyperplasia (Melanocytic Nuclear Atypia), Lamellar Fibroplasia, Concentric Fibroplasia, and Lymphocytes as Criteria for Diagnosis Histopathologic of Dysplastic Nevi?

…bed), and is characterized further by discrete small nests of melanocytes with small monomorphic oval nuclei and scant usually pale cytoplasm confined to the dermoepidermal junction and papillary dermis. Those few findings identify with specificity t…

Histologic Diagnosis of Inflammatory Skin Diseases

Hair Follicles

…k of a follicular bulb consists of matrical cells among which melanocytes are interspersed (Figs. 1.25 and 1.26). The base of a bulb encloses a follicular papilla formed of connective tissue in the shape of an inverted pinecone. When a follicle is i…