Dermatology Practical & Conceptual

Nail matrix melanoma: consecutive cases in a general practice

…men of nail matrix from Case 1. It is difficult to distinguish melanocytes from keratinocytes. [Copyright: ©2012 Rosendahl et al.] Figure 5. High power micrograph of the H&E stained section shown in Figure 4 shows plump pale melanocytes at the…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Nevus?

…evomelanocytes.” Those cells, in actuality, are abnormal melanocytes. They can be identified as melanocytes because their cytoplasm possesses accoutrements requisite for the manufacture of melanin, to wit, premelanosomes. In short, what are cal…

Differential Diagnosis in Dermatopathology

Spitz’s nevus, compound type vs. Melanoma

Pigmented macules and patches mostly in the middle third of the face, vertically and horizontally, distributed symmetrically and occurring mainly in postpubescent women as a consequence of the combined effects of estrogen and ultraviolet light on me…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Nuclear Atypia, Cytoplasmic Atypia, and Architectural Atypia?

“The cytologically atypical melanocytes have the same features as cytologically atypical cells in any neoplastic system. Such cells are larger than normal melanocytes or the intraepidermal melanocytes of an ordinary melanocytic nevus.”…

Histologic Diagnosis of Inflammatory Skin Diseases

Hair Follicles

…corporate melanosomes by clipping off the ends of dendrites of melanocytes by a mechanism termed apocopation, matrical cells of a follicle do the same to dendrites of melanocytes positioned in the bulb. Color of hair depends primarily on the amount a…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Persistent Lentiginous Melanocytic Hyperplasia, Atypical Melanocytic Hyperplasia (Melanocytic Nuclear Atypia), Lamellar Fibroplasia, Concentric Fibroplasia, and Lymphocytes as Criteria for Diagnosis Histopathologic of Dysplastic Nevi?

“In summary, melanocytic nevi with dysplasia have five distinctive histologic features: (1) persistent lentiginous melanocytic hyperplasia; (2) atypical melanocytic hyperplasia (melanocytic nuclear atypia); (3) lamellar fibroplasias; (4) conc…