Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Scleroderma?

…al alone because, except for hardness and some discoloration, morphea bears little resemblance to acrosclerosis, and lesions of linear scleroderma are very different from those of lichen sclerosus et atrophicus. The denominator in common for diagnosi…

Differential Diagnosis in Dermatopathology

Discussions

…wn conventionally as lupus profundus, and the panniculitis of morphea, referred sometimes to as morphea profundus, have several findings histopathologic in common: infiltrates of lymphocytes and plasma cells mostly in the subcutaneous fat, foci of fa…

Histologic Diagnosis of Inflammatory Skin Diseases

Nephrogenic fibrosing dermopathy

…21; especially the manifestations of them known as widespread morphea and acrosclerosis, present themselves with thickening and hardening of the skin of the distal part of extremities always in acrosclerosis and of extremities above the acra and on t…

Histologic Diagnosis of Inflammatory Skin Diseases

Identification of Basic Patterns: Subcutaneous Fat: Panniculitis

…culitis, namely, erythema nodosum, necrobiosis lipoidica, and morphea in its many expressions, from linear scleroderma to fasciitis with eosinophils. In some instances, e.g., in exceptional, fully developed lesions of erythema nodosum, lobules and se…

Histologic Diagnosis of Inflammatory Skin Diseases

Images

…standing lesions of radiation dermatitis differ from those of morphea by sclerosis being present in the reticular dermis of radiodermatitis (rather than discrete, crowded, thickened bundles of collagen there as is the case in morphea) and by the pres…

Differential Diagnosis in Dermatopathology

Discussions

…n abundance. The form of scleroderma under discussion here is morphea, a condition that may express itself as a single patch or plaque, a few of those lesions, or many ones of them widespread. Independent of the number of patches or plaques, morphea

Histologic Diagnosis of Inflammatory Skin Diseases

Radiation dermatitis and panniculitis

…zones of radiation sclerosis. Differential diagnosis clinical Morphea, including lichen sclerosus et atrophicus, lacks poikilodermatous changes and does not ulcerate. Findings histopathologic Early Lymphocytes around venules and neutrophils scattere…

Histologic Diagnosis of Inflammatory Skin Diseases

Algorithms Predicated on “Nonspecific” Findings

…in nodules at the junction of widened septa and fat lobules = Morphea     Decorated “Tombstones” Discrete dermal papillae covered by a single row of basal keratocytes that project into an intraepidermal blister. Click…

Histologic Diagnosis of Inflammatory Skin Diseases

Study By Disease

…’s nodule (Quiz #607) Molluscum contagiosum (Quiz #496) Morphea (Quiz #24) Morphea (Quiz #39) Morphea (Quiz #171) Morphea (Quiz #172) Morphea (Quiz #173) Morphea (Quiz #174) Morphea (Quiz #175) Morphea (Quiz #487) Morphea (Quiz #488) Morphea, c…

Histologic Diagnosis of Inflammatory Skin Diseases

Applicable Terms

…umber and/or size of collagen bundles, e.g., in long-standing morphea, i.e., so-called idiopathic atrophoderma of Pasini and Pierini. Figure 3.5 Superficial atrophy. A. Clinical. B. Histopathologic. BALLOONING [It. ballone (large ball) + ME -ing (…