Differential Diagnosis in Dermatopathology

Discussions

…own conventionally as lupus profundus, and the panniculitis of morphea, referred sometimes to as morphea profundus, have several findings histopathologic in common: infiltrates of lymphocytes and plasma cells mostly in the subcutaneous fat, foci of f…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Scleroderma?

…ause, probable mechanisms of formation, and biologic behavior. Morphea and its superficial variant, that is, lichen sclerosus et atrophicus, may disappear without therapy, although some lesions of morphea regress slowly over years to become what is t…

Histologic Diagnosis of Inflammatory Skin Diseases

Nephrogenic fibrosing dermopathy

…d of extremities above the acra and on the trunk in widespread morphea, but not with papules and nodules. Eosinophilic fasciitis, better termed fasciitis with eosinophils, is a variant deep of morphea and is characterized by induration of the distal…

Histologic Diagnosis of Inflammatory Skin Diseases

Images

…gstanding lesions of radiation dermatitis differ from those of morphea by sclerosis being present in the reticular dermis of radiodermatitis (rather than discrete, crowded, thickened bundles of collagen there as is the case in morphea) and by the pre…

Histologic Diagnosis of Inflammatory Skin Diseases

Identification of Basic Patterns: Subcutaneous Fat: Panniculitis

See Fig. 5.385 A-C. Figure 5.385 Patterns of panniculitis. A. Septal mostly. B. Lobular mostly. C. Septal and lobular “equally.” At scanning magnification, the normal subcutaneous fat is seen to be segregated by struts of fibrous tiss…

Differential Diagnosis in Dermatopathology

Discussions

…in abundance. The form of scleroderma under discussion here is morphea, a condition that may express itself as a single patch or plaque, a few of those lesions, or many ones of them widespread. Independent of the number of patches or plaques, morphea

Histologic Diagnosis of Inflammatory Skin Diseases

Radiation dermatitis and panniculitis

…radiation sclerosis on one hand and the inflammatory stage of morphea on the other. Pseudosclerodermatous panniculitis, in common with the inflammatory stage of morphea, is characterized by lymphoplasmacytic infiltrates in the dermis and septa of th…

Histologic Diagnosis of Inflammatory Skin Diseases

Algorithms Predicated on “Nonspecific” Findings

In this section, algorithms used to reach specific diagnosis are predicated on “nonspecific” findings recognized best at higher magnification. Other changes requisite for specific diagnoses, i.e., denominators that are essential, then ar…

Histologic Diagnosis of Inflammatory Skin Diseases

Study By Disease

…r’s nodule (Quiz #607) Molluscum contagiosum (Quiz #496) Morphea (Quiz #24) Morphea (Quiz #39) Morphea (Quiz #171) Morphea (Quiz #172) Morphea (Quiz #173) Morphea (Quiz #174) Morphea (Quiz #175) Morphea (Quiz #487) Morphea (Quiz #488) Morphea,…

Histologic Diagnosis of Inflammatory Skin Diseases

Applicable Terms

…us and much, or all, of the dermis of chronic radiodermatitis. Morphea, other than the form of it confined to the upper part of the dermis and known as lichen sclerosus et atrophicus, is not typified by sclerosis; collagen bundles in a lesion of morp…