Search Results for: mucin

Differential Diagnosis in Dermatopathology

Pretibial myxedema vs. Scleromyxedema

Lupus erythematosus (LE) is a multisystem autoimmune connective tissue disease that can have protean effects on the skin. In some patients only the skin is involved, while in others, life-threatening internal complications can arise, ranging from…

Differential Diagnosis in Dermatopathology

Papular mucinosis vs Interstitial granuloma annulare

Lupus erythematosus (LE) is a multisystem autoimmune connective tissue disease that can have protean effects on the skin. In some patients only the skin is involved, while in others, life-threatening internal complications can arise, ranging from…

Differential Diagnosis in Dermatopathology

Granuloma annulare vs. Necrobiosis lipoidica

Lupus erythematosus (LE) is a multisystem autoimmune connective tissue disease that can have protean effects on the skin. In some patients only the skin is involved, while in others, life-threatening internal complications can arise, ranging from…

Histologic Diagnosis of Inflammatory Skin Diseases

Scleromyxedema

…are there inflammatory cells other than fibrocytes. In brief, the earliest changes in scleromyxedema, known also as papular mucinosis and lichen myxedematous, are deposits of mucin so impressive that the findings could be misconstrued as those of…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Reticular Erythematous Mucinosis?

…utaneous mucinosis,” also reputed to be a disease sui generis. In our estimation, however, both reticular erythematous mucinosis and plaque-like cutaneous mucinosis are one of many manifestations cutaneous of lupus erythematosus, to wit, the…

Histologic Diagnosis of Inflammatory Skin Diseases

Granuloma annulare

…being interstitial. In the former, epithelioid histiocytes are aligned in a palisade around a locus that consists mostly of mucin, but sometimes also of fibrin, degenerated collagen, and nuclear “dust,” presumably of neutrophils,…

Histologic Diagnosis of Inflammatory Skin Diseases

Applicable Terms

…s (e.g., abnormal melanocytes in melanomas), deposits (e.g., urates in gouty tophi), or elements of connective tissue (e.g., mucin in focal mucinosis) in the skin, in the subcutaneous fat, or in both of them together (Fig. 3.25). Nodules may evolve…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Sclerotic Fibroma?

…te locus in the uppermost part of the dermis, consisting of a proliferation of fibrocytes, prominent sclerosis with abundant mucin, and a markedly increased number of plump endothelial cells, changes that are seen in some sclerotic fibromas in…