Differential Diagnosis in Dermatopathology

Granuloma annulare vs. Necrobiosis lipoidica

An inflammatory process that expresses itself in the skin in protean ways that are variations on a basic pathologic theme, and includes evanescent patches on the face (“butterfly blush”), scaly papules and plaques that resolve with atrop…

Histologic Diagnosis of Inflammatory Skin Diseases

Scleromyxedema

Scleromyxedema Synonyms Papular mucinosis Lichen myxedematosus Presentation stereotypical Age and sex Adults of either sex Distribution of lesions Widespread Individual lesions Papules that produce diffuse thickening of the skin Course Protracted Va…

Differential Diagnosis in Dermatopathology

Papular mucinosis vs Interstitial granuloma annulare

An inflammatory process that expresses itself in the skin in protean ways that are variations on a basic pathologic theme, and includes evanescent patches on the face (“butterfly blush”), scaly papules and plaques that resolve with atrop…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Reticular Erythematous Mucinosis?

…rome, a combination of the main signs, reticular erythema and mucinosis, was used to name this entity REM syndrome.” Steigleder GK, Gartmann H, Linker U. REM syndrome: reticular erythematous mucinosis (round-cell erythematosus): a new entity?…

Histologic Diagnosis of Inflammatory Skin Diseases

Granuloma annulare

…ar dermis, histiocytes in palisaded and/or interstitial array Mucin discernible in foci in which histiocytes predominate Fully developed—dermal granuloma annulare Same findings as in early lesions but exaggerated: Histiocytes arranged in a palisade…

Histologic Diagnosis of Inflammatory Skin Diseases

Applicable Terms

…ediately above and below the basement membrane, and to “mucinous degeneration” of a neural neoplasm where “degeneration” is employed as a synonym for deposits of mucin. “Fatty degeneration” of neutrophils has been…

Histologic Diagnosis of Inflammatory Skin Diseases

Images

…mostly + 10.70.1B: Fibrosing granulation tissue, abundant mucin, and scattered lymphocytes = Nodular fasciitis  The changes pictured are a response to external trauma akin to those in an early stage of a variety of scarring processes, e.g., derma…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Sclerotic Fibroma?

…with a laminated or tortuous appearance, embedded in abundant mucin. A number of fibromas showed striking hyalinization; these may represent a second microscopic hallmark of Cowden’s disease in addition to facial tricholemmoma.” Starink T…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Necrobiosis?

…rmal collagen. …The necrobiotic area contains prominent mucin in granuloma annulare, fibrin in rheumatoid nodule, and degenerated collagen in necrobiosis lipoidica.” Warschaw KE, Cotton JP. Glossary. In: Farmer ER, Hood AF, eds. Patholog…