Histologic Diagnosis of Inflammatory Skin Diseases

Scleromyxedema

…anged in whorls or in intersecting short fascicles Presence of mucin among bundles of collagen Differential diagnosis histopathologic Granuloma annulare may resemble early lesions of scleromyxedema in which mucin is deposited focally in conjunction…

Differential Diagnosis in Dermatopathology

Papular mucinosis vs Interstitial granuloma annulare

An inflammatory process that expresses itself in the skin in protean ways that are variations on a basic pathologic theme, and includes evanescent patches on the face (“butterfly blush”), scaly papules and plaques that resolve with atrop…

Histologic Diagnosis of Inflammatory Skin Diseases

Applicable Terms

…rates in gouty tophi), or elements of connective tissue (e.g., mucin in focal mucinosis) in the skin, in the subcutaneous fat, or in both of them together (Fig. 3.25). Nodules may evolve from macules through papules in melanoma, mycosis fungoides, an…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Reticular Erythematous Mucinosis?

…drome, a combination of the main signs, reticular erythema and mucinosis, was used to name this entity REM syndrome.” Steigleder GK, Gartmann H, Linker U. REM syndrome: reticular erythematous mucinosis (round-cell erythematosus): a new entity?…

Histologic Diagnosis of Inflammatory Skin Diseases

Granuloma annulare

Granuloma annulare Presentation stereotypical Age and sex Any age in both sexes Distribution of lesions Localized, often to extensor aspects of extremities, or widespread Configuration of lesions Annular, sometimes arcuate Arrangement of lesions Sca…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Sclerotic Fibroma?

“Nine biopsies revealed a distinctive type of fibroma characterized by an organized pattern of interwoven fascicles of collagen bundles with a laminated or tortuous appearance, embedded in abundant mucin. A number of fibromas showed striking…

Histologic Diagnosis of Inflammatory Skin Diseases

Images

Images 10.70.1A: Panniculitis, septal mostly + 10.70.1B: Fibrosing granulation tissue, abundant mucin, and scattered lymphocytes = Nodular fasciitis ┬áThe changes pictured are a response to external trauma akin to those in an early stage o…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Necrobiosis?

“This latter category, where the cells are destroyed during the course of the process, I proposed a few years ago to designate by a term which has been employed to express disease generally by K. H. Schultz, viz., necrobiosis. Necrobiosis is…

Histologic Diagnosis of Inflammatory Skin Diseases

Necrobiosis lipoidica

…nterpret degeneration of collagen in necrobiosis lipoidica for mucin of granuloma annulare; the former is blue and amorphous, whereas the latter is blue and finely granular. Mucin is stained a brilliant aquamarine by colloidal iron, but degeneration…

Differential Diagnosis in Dermatopathology

Discussions

…opathologically, in sections stained by hematoxylin and eosin, mucin appears as basophilic granular and stringy material. At scanning magnification, scleromyxedema seems to be a kind of fibroplasia, whereas pretibial myxedema clearly is a mucinosis….